Response of free fatty acids to coffee and caffeine

Bellet, Samuel; Kershbaum, Alfred; Finck, E M

doi:10.1016/0026-0495(68)90054-1

Cited by 130 publications

(45 citation statements)

References 12 publications

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“…Because of the pronounced effect of caffeine on FFA mobilization (17)(18)(19)(20), the epididymal and perirenal depots were examined to determine if this caffeine dosage (10 mg/kg/day) would affect adipocyte size or number. Regarding adiposity, our nonsignificant findings were consistent with other studies in which dosages as high as 50 mg/kg produced no alterations in adipose size or number (2 1).…”

Section: Effect Of Caffeine Intake During Lactation and Postweaningmentioning

confidence: 99%

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Effect of Chronic Caffeine Intake on Myocardial Function during Early Growth

et al. 1987

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ABSTRACT. The purpose of these studies was to evaluate the effects of chronic caffeine ingestion on the myocardium during fetal and neonatal growth and development. The isolated perfused working heart preparation was used to evaluate cardiac function. During gestation and lactation, one group of dams consumed a caffeine supplemented diet (10 mg/kg/day). Their offspring were sacrificed and the hearts analyzed 50 days after birth. We found that the intake of caffeine by the dams resulted in significant increases in the offspring's coronary flow, peak systolic pressure, and myocardial work. A second group of dams ingested a diet containing caffeine (10 mg/kg/day) during lactation only. Their pups continued to consume the caffeine diet until 50 days. Caffeine is extensively used (I, 2) and therefore much concern has arisen concerning its potential for developmental toxicity. Caffeine is known to affect the central nervous system, cardiac muscle, cardiac output (2-4), blood pressure, heart rate (I), catecholamine release, and renin activity (2, 5, 6). Although the exact mechanisms of caffeine's cardiovascular effects are still controversial (7), the reports imply that the organism rapidly develops a tolerance to caffeine's acute actions and that the acute effects do not persist (5,8).Presently, insufficient information is available regarding chronic caffeine administration during early growth and development. Researchers have reported that caffeine and its metabolites readily cross the placenta and distribute evenly in fetal Received June 25, 1986; accepted November 26, 1986 tissue (9-12). During pregnancy, all the caffeine may not be metabolized (13,14) possibly causing an accumulation in maternal and fetal tissues. Caffeine has also been found in mother's milk (15, 16); thus, caffeine is available to the suckling infant. In addition, caffeine is known to activate the sympathetic nervous system, evaluate plasma free fatty acids (17-20), and decrease adipocyte size (2 1).The purposes of the present study were: (a) to determine whether caffeine ingestion by dams during fetal development and lactation had any long-term effect on the offspring's cardiac performance 50 days after birth, (b) to ascertain whether caffeine intake by the offspring during nursing and after weaning resulted in cardiac dysfunction in 50-day-old rats, and (c) to evaluate whether chronic caffeine consumption for 50 days during lactation and postweaning affected adipocyte size and number. METHODS Effect of caffeine intake during gestation and lactation.Timed pregnant (known date of conception) Sprague-Dawley rats (Holtzman Co., Madison, WI) were fed Purina Laboratory Chow at our animal facility. On day 13 of pregnancy (sperm positive as day I), randomly selected dams in the control group were fed a 20% protein diet (22). These control dams were fed ad libitum.On delivery, several litters were combined if the delivery time was within an 8-h range. Randomly selected pups were then assigned to each dam and the dams consumed the same diet during lacta...

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Section: Effect Of Caffeine Intake During Lactation and Postweaningmentioning

confidence: 99%

“…Caffeine has also been found in mother's milk (15,16); thus, caffeine is available to the suckling infant. In addition, caffeine is known to activate the sympathetic nervous system, evaluate plasma free fatty acids (17)(18)(19)(20), and decrease adipocyte size (2 1).…”

mentioning

confidence: 99%

Effect of Chronic Caffeine Intake on Myocardial Function during Early Growth

et al. 1987

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“…This may be due solely to cyclic AMP elevation following inhibition of cyclic AMP phosphodiesterase [24,25] or to cyclic AMP independent effects on calcium mobilisation [26,27]. It is also possible that some of the observed effects resulted from altered supply of maternal fuels to the fetus or neonate, through effects on tissue lipolysis [28], rather than from direct exposure to caffeine. Irrespective of the mechanism involved, the observations may have implications relating to pancreatic function and glucose homeostasis in infants of mothers ingesting methylxanthines.…”

Section: Discussionmentioning

confidence: 99%

The effect of maternal caffeine ingestion on pancreatic function in the neonatal rat

1982

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Summary. Pancreatic function was investigated in neonatal suckling offspring of caffeine-ingesting dams, with or without maternal sucrose supplementation, throughout pregnancy and lactation. In offspring of rats ingesting caffeine without sucrose supplementation, there was initial hyperinsulinaemia, followed by a progressive fall of plasma insulin to subnormal levels. This fall in plasma insulin coincided with depletion of pancreatic insulin stores. Both the fall in plasma insulin and depletion of pancreatic insulin stores were prevented by sucrose supplementation of caffeine-ingesting dams. Offspring of dams fed sucrose alone and control offspring also maintained pancreatic insulin stores and circulating insulin levels over the first 14 days of postnatal life. Pancreases from offspring of caffeine-exposed animals tested in vitro showed enhanced sensitivity of the insulin release process to glucose. This was reflected in the glucose concentration required to elicit half-maximal insulin release (2.4 ___ 0.2 mmol/1 for caffeine offspring, 2.3 + 0.2 mmol/1 for caffeine with sucrose, 3.8 _+ 0.3 mmol/1 for sucrose and 4.1 + 0.3 mmol/1 for control offspring, mean +_ SEM). In contrast, offspring of sucrose-supplemented (with or without caffeine) dams showed increased sensitivity of the proinsulin biosynthetic process to glucose, whereas offspring of dams ingesting caffeine alone showed no significant enhancement of the biosynthetic process compared with control offspring. Thus enhanced sensitivity of the insulin secretory process to glucose without a change in the sensitivity of the biosynthetic process in the offspring of the caffeine ingesting (nonsucrose supplemented) dams could explain the progressive depletion of pancreatic insulin stores and eventual hypoinsulinaemia seen in this group.

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“…189 Diversos estudos em humanos verificaram também um aumento da lipólise após a ingestão de cafeína 186,[193][194][195][196][197] ou café. 192,193,195,198,199 Mais uma vez, não se observou um aumento significativo da lipólise após a ingestão de descafeinado. 193,195,200 Adicionalmente, alguns estudos mostram que o efeito termogénico 186,191,192 e lipolítico 191,195 da cafeina é mais pronunciado em indivíduos não obesos do que em obesos.…”

Section: Café E Peso Corporalunclassified

Benefícios do café na saúde: mito ou realidade?

Alves¹,

Casal²,

Oliveira³

2009

Quím. Nova

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Recebido em 18/11/08; aceito em 8/4/09; publicado na web em 22/9/09 HEALTH BENEFITS OF COFFEE: MYTH OR REALITY? Coffee is widely consumed and appreciated all over the world, both for their stimulating effect and organoleptic characteristics. Due to its complex chemical composition and the factors involving brews preparation, the consumer is exposed to a wide range of chemical compounds. Several investigations aimed to clarify and understand coffee health effects. There is no evidence that moderate consumption could be harmful. On the contrary, some benefits and possible protective effects against several pathologies have been suggested. This review compiles the main conclusions related with the "coffee and health" topic, reporting, when possible, the chemicals involved.Keywords: coffee; health; review. INTRODUÇÃOO café é uma das matérias-primas com maior importância no comércio internacional. É igualmente uma das bebidas mais apreciadas em todo mundo, não só pelas suas características organolépticas, mas também pelo seu efeito estimulante. Dado o seu elevado e distribuído consumo, os potenciais efeitos na saúde causados por esta bebida suscitaram, desde cedo, o interesse da comunidade científica.Inicialmente, o foco destes estudos teve unicamente como base a cafeína e os seus efeitos fisiológicos, sempre com alguma conotação nefasta. Mais recentemente, novas linhas de investigação têm dado relevo a outros compostos químicos, igualmente presentes no café, sugerindo até potenciais efeitos benéficos e protectores ao nível da saúde dos consumidores desta bebida.A composição química do grão verde de café é bastante complexa.1,2 Durante o processo de torrefacção ocorrem, ainda, diversas reacções químicas, através das quais se degradam e/ou formam inúmeros compostos. Estima-se que o grão de café torrado possua mais de 2000 compostos químicos alguns destes com actividades biológicas conhecidas (adversas e/ou benéficas).1,2 Deste modo, os efeitos do consumo de café irão depender da qualidade e quantidade dos compostos químicos ingeridos, estando o consumo moderado normalmente descrito como a ingestão de 3 a 5 doses diárias de café (aproximadamente 150-300 mg de cafeína/dia). 3,4 No entanto, a composição química da bebida é bastante variável e largamente dependente das espécies de café utilizadas, sendo as mais comuns a Coffea arabica (cerca de 70% da produção mundial) e a Coffea canephora var. robusta (mais de 25%).2 Estas duas espécies diferem entre si pelas suas características organolépticas, físicas e químicas. O aroma e o sabor do café arábica são mais apreciados que os do robusta, sendo por isso mais valorizado comercialmente. O café robusta resiste mais facilmente ao ataque de pragas durante o seu cultivo e é especialmente utilizado para aumentar o corpo e a espuma de algumas bebidas, assim como para a produção de café solúvel. Além da influência da espécie de café, o tipo de processamento a que os grãos verdes são sujeitos (via seca, húmida ou mista, descafeinização), o grau de torra e de moagem, assim como o mét...

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Response of free fatty acids to coffee and caffeine

Cited by 130 publications

References 12 publications

Effect of Chronic Caffeine Intake on Myocardial Function during Early Growth

Effect of Chronic Caffeine Intake on Myocardial Function during Early Growth

The effect of maternal caffeine ingestion on pancreatic function in the neonatal rat

Benefícios do café na saúde: mito ou realidade?

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