Response of genes related to iron and porphyrin transport in Porphyromonas gingivalis to blue light

Yuan, Lintian; Wang, Yucheng; Zong, Yanni; Dong, Fan; Zhang, Ludan; Wang, Guiyan; Dong, Huihua; Wang, Yuguang

doi:10.1016/j.jphotobiol.2023.112670

Cited by 3 publications

(4 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The current thinking is that blue light is absorbed by endogenous photosensitizers, molecular components of a bacterium that absorb photons and transfer the photon energy to generate toxic reactive oxygen species (ROS) [ 33 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ]. The absorption of photon energy raises the photosensitizer from the ground energy state to an excited state.…”

Section: Mode 2: Blue Light Inactivation Through Ros Generation (Abl)...mentioning

confidence: 99%

“…Specific applications in dentistry need to be developed and safety and efficacy validated in clinical trials. Zhang et al (2023) [161] have developed an interesting application of aBL for treating peri-implantitis, so far tested only in implants placed in the tibia of rabbits. A 410 nm LED is incorporated into a zirconia implant and provides low-level, continuous blue light irradiation.…”

Section: Summary Andmentioning

confidence: 99%

See 1 more Smart Citation

Photoinactivation and Photoablation of Porphyromonas gingivalis

Harris,

Sulewski

2023

Pathogens

View full text Add to dashboard Cite

Several types of phototherapy target human pathogens and Porphyromonas gingivitis (Pg) in particular. The various approaches can be organized into five different treatment modes sorted by different power densities, interaction times, effective wavelengths and mechanisms of action. Mode 1: antimicrobial ultraviolet (aUV); mode 2: antimicrobial blue light (aBL); mode 3: antimicrobial selective photothermolysis (aSP); mode 4: antimicrobial vaporization; mode 5: antimicrobial photodynamic therapy (aPDT). This report reviews the literature to identify for each mode (a) the putative molecular mechanism of action; (b) the effective wavelength range and penetration depth; (c) selectivity; (d) in vitro outcomes; and (e) clinical trial/study outcomes as these elements apply to Porphyromonas gingivalis (Pg). The characteristics of each mode influence how each is translated into the clinic.

show abstract

Section: Mode 2: Blue Light Inactivation Through Ros Generation (Abl)...mentioning

confidence: 99%

Section: Summary Andmentioning

confidence: 99%

Photoinactivation and Photoablation of Porphyromonas gingivalis

Harris,

Sulewski

2023

Pathogens

View full text Add to dashboard Cite

show abstract

“…Curcumin (maximum absorption wavelength: 425 nm), riboflavin (266 nm, 373 nm, 445 nm), rose bengal (550 nm), erythrosine (530 nm), and sinoporphyrin sodium (366 nm) have been used as photosensitizers in a-PDT using third-generation blue LED light [55]. The antibacterial effect of a-PDT in combination with blue LEDs and the aforementioned photosensitizers has been demonstrated in vitro on periodontal bacteria commonly found in patients with periodontitis, such as A. actinomycetemcomitans, Campylobacter rectus, Fusobacterium nucleatum, Parvimonas micra, P. gingivalis, Tannerella forsythia, Prevotella intermedia, and Streptococcus gordonii [56][57][58][59][60][61][62][63][64][65]. In addition, the antibacterial activity of blue light irradiation alone has been demonstrated against some oral bacteria (Figure 3) [36,[66][67][68][69][70][71], further MRSA, and novel coronavirus [72,73].…”

Section: Blue Lightmentioning

confidence: 99%

“…Black-pigmented bacteria, including P. gingivalis and P. intermedia, which are commonly associated with periodontal diseases, degrade hemoglobin to derive heme, and endogenous porphyrin is produced when the bacteria further acquire iron from heme [74]. The importance of porphyrins in the antimicrobial action of blue light has been suggested [74]; irradiated blue light reacts with endogenous porphyrin as a photosensitizer, leading to the production of ROSs, which efficiently and selectively kill bacteria [3,34,57,68,75]. This characteristic could have clinical advantages, as blue light exposure without a photosensitizer suppresses only the growth of periodontal pathogenic bacteria possessing endogenous porphyrin while simultaneously minimizing the impact on the natural microbiome.…”

Section: Blue Lightmentioning

confidence: 99%

Application of Different Wavelengths of LED Lights in Antimicrobial Photodynamic Therapy for the Treatment of Periodontal Disease

Takeuchi,

Aoki,

Hiratsuka

et al. 2023

Antibiotics

View full text Add to dashboard Cite

Therapeutic light has been increasingly used in clinical dentistry for surgical ablation, disinfection, bio-stimulation, reduction in inflammation, and promotion of wound healing. Photodynamic therapy (PDT), a type of phototherapy, has been used to selectively destroy tumor cells. Antimicrobial PDT (a-PDT) is used to inactivate causative bacteria in infectious oral diseases, such as periodontitis. Several studies have reported that this minimally invasive technique has favorable therapeutic outcomes with a low probability of adverse effects. PDT is based on the photochemical reaction between light, a photosensitizer, and oxygen, which affects its efficacy. Low-power lasers have been predominantly used in phototherapy for periodontal treatments, while light-emitting diodes (LEDs) have received considerable attention as a novel light source in recent years. LEDs can emit broad wavelengths of light, from infrared to ultraviolet, and the lower directivity of LED light appears to be suitable for plaque control over large and complex surfaces. In addition, LED devices are small, lightweight, and less expensive than lasers. Although limited evidence exists on LED-based a-PDT for periodontitis, a-PDT using red or blue LED light could be effective in attenuating bacteria associated with periodontal diseases. LEDs have the potential to provide a new direction for light therapy in periodontics.

show abstract