Response of glutathione system and carotenoids to sublethal copper in the postlarvae of Penaeus indicus

Paila, Rupa Vani; Yallapragada, Prabhakara Rao; Thatipaka, Samuel David Raj

doi:10.1016/j.ecoenv.2011.08.023

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…Malondialdehyde is the final product of polyunsaturated fatty acid peroxidation and usually reflects the level of oxidative stress damage (Liu, Wang, et al, 2021b). GSH‐Px protects the organisms from oxidative damage by converting peroxides and hydroxyl radicals to non‐toxic forms (Vani Paila et al, 2012). Our study showed that the archaeal carotenoids enhanced the activity of GSH‐Px and reduced the MDA content in the liver, indicating the better antioxidative status of the liver.…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation of archaeal carotenoids improved antioxidative capacity and regulated immune‐related gene expression of golden trout Oncorhynchus mykiss against challenge

Xie

Deng

et al. 2022

Aquaculture Research

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Archaeal carotenoids, as novel bioactive compound, are stronger free radical scavenger. The effects of archaea Halorubrum carotenoids on skin coloration, antioxidative status and immune-related genes expression of golden trout Oncorhynchus mykiss were investigated. In total, 420 fish (10.90 ± 0.06 g) were divided into three groups with four replicates, and fed with commercial diets containing 0 (Ctrl), 25 mg/kg (P25)

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Section: Discussionmentioning

confidence: 99%

Dietary supplementation of archaeal carotenoids improved antioxidative capacity and regulated immune‐related gene expression of golden trout Oncorhynchus mykiss against challenge

Xie

Deng

et al. 2022

Aquaculture Research

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“…The toxicity of Cu 2+ to crustaceans has also garnered attention. Long-term exposure to Cu 2+ (0.1641 ppm, 30 days) suppresses the glutathione system in Penaeus indicus [ 19 ]. Furthermore, sub-lethal Cu 2+ exposure leads to necrosis and the loss of regular structures in the gills and hepatopancreas of Litopenaeus vannamei [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Copper Exposure on Oxidative Stress, Apoptosis, Endoplasmic Reticulum Stress, Autophagy and Immune Response in Different Tissues of Chinese Mitten Crab (Eriocheir sinensis)

Feng

Song

et al. 2022

Antioxidants

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High concentrations of copper (Cu2+) pose a great threat to aquatic animals. However, the mechanisms underlying the response of crustaceans to Cu2+ exposure have not been well studied. Therefore, we investigated the alterations of physiological and molecular parameters in Chinese mitten crab (Eriocheir sinensis) after Cu2+ exposure. The crabs were exposed to 0 (control), 0.04, 0.18, and 0.70 mg/L of Cu2+ for 5 days, and the hemolymph, hepatopancreas, gills, and muscle were sampled. The results showed that Cu2+ exposure decreased the antioxidative capacity and promoted lipid peroxidation in different tissues. Apoptosis was induced by Cu2+ exposure, and this activation was associated with the mitochondrial and ERK pathways in the hepatopancreas. ER stress-related genes were upregulated in the hepatopancreas but downregulated in the gills at higher doses of Cu2+. Autophagy was considerably influenced by Cu2+ exposure, as evidenced by the upregulation of autophagy-related genes in the hepatopancreas and gills. Cu2+ exposure also caused an immune response in different tissues, especially the hepatopancreas, where the TLR2-MyD88-NF-κB pathway was initiated to mediate the inflammatory response. Overall, our results suggest that Cu2+ exposure induces oxidative stress, ER stress, apoptosis, autophagy, and immune response in E. sinensis, and the toxicity may be implicated following the activation of the ERK, AMPK, and TLR2-MyD88-NF-κB pathways.

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Copper-induced oxidative stress and biomarkers in the postlarvae of Penaeus indicus

Thatipaka¹,

Paila²,

Polaki³

2020

Environ Sci Pollut Res

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Response of glutathione system and carotenoids to sublethal copper in the postlarvae of Penaeus indicus

Cited by 4 publications

References 30 publications

Dietary supplementation of archaeal carotenoids improved antioxidative capacity and regulated immune‐related gene expression of golden trout Oncorhynchus mykiss against challenge

Dietary supplementation of archaeal carotenoids improved antioxidative capacity and regulated immune‐related gene expression of golden trout Oncorhynchus mykiss against challenge

Effects of Copper Exposure on Oxidative Stress, Apoptosis, Endoplasmic Reticulum Stress, Autophagy and Immune Response in Different Tissues of Chinese Mitten Crab (Eriocheir sinensis)

Copper-induced oxidative stress and biomarkers in the postlarvae of Penaeus indicus

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