Response of Layer Breeders to Dietary Acetylsalicylic Acid.

McDaniel, C. D.; Balog, J. M.; Freed, Marisue; Elkin, Robert G.; Wellenreiter, R. H.; Hester, Patricia Y.

doi:10.3382/ps.0721084

Cited by 22 publications

(13 citation statements)

References 26 publications

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“…The use of cyclooxigenase inhibitors like acetylsalicylic acid and indomethacin to improve the performance of broilers maintained in a heat stress environment has been postulated. Some workers have reported an improvement in egg production by feeding acetylsalicylic acid (Reid et al 1964). MacDaniel et al (1993, however, showed that chronic feeding of acetylsalicylic acid did not improve egg production or feed efficiency.…”

Section: Introductionmentioning

confidence: 98%

Effect of indomethacin on hyperthermia induced by heat stress in broiler chickens

Furlan

Macari

Malheiros

et al. 1998

International Journal of Biometeorology

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An investigation was carried out to verify whether the heat stress hyperthermia response of broilers is prostaglandin-dependent. Male broiler chickens of the Hubbard-Petterson strain, aged 35-49 days, were used. Chickens were injected with indomethacin (1 mg/kg intraperitoneally) 15 min before or 2 h after heat exposure (at 35 degrees C for 4 h), and rectal temperature was measured before injection and up to 4 h thereafter. Birds were separated into two groups with and without access to water during heat stress. The increase in rectal temperature was lower (P < 0.05) in birds with access to drinking water during heat exposure. All birds injected with indomethacin exhibited an increase in rectal temperature, irrespective of whether indomethacin was administered before or in the course of the rise in temperature. The results revealed that the increase in rectal temperature during heat exposure is not prostaglandin-dependent, and that the use of cyclooxigenase inhibitors is not recommended to attenuate heat stress hyperthermia in broiler chickens.

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Section: Introductionmentioning

confidence: 98%

Effect of indomethacin on hyperthermia induced by heat stress in broiler chickens

Furlan

Macari

Malheiros

et al. 1998

International Journal of Biometeorology

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“…Known side effects of long-term ASA administration include internal and gastrointestinal bleeding (Mielke, 1981;Clissold, 1986;Weissmann, 1991). Because several birds in another experiment may have died from internal bleeding (McDaniel et al, 1993), the .40% levels of ASA may have inhibited PG synthesis in thrombocytes (Smith and Willis, 1971). However, under the experimental conditions of the present study, the ovarian and uterine sources of PG synthetase apparently were not affected.…”

Section: Discussionmentioning

confidence: 97%

Response of Layer Breeders to Dietary Acetylsalicylic Acid. 2. Effects on Circulating Concentrations of Prostaglandin F2α

et al. 1993

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White Leghorn breeder hens were fed 0, .05, or .40% acetylsalicylic acid (ASA) for either 1 wk or 1 mo. Blood samples were collected 4 h postentrance of an egg into the uterus (baseline) and at oviposition of a hardshelled (HS) egg. Plasma samples were analyzed for prostaglandin (PG) F2 alpha by radioimmunoassay. Peripheral PGF2 alpha concentrations peaked upon oviposition of a HS egg in both ASA-fed hens as well as the controls (0% ASA). The levels of dietary ASA and the duration of time the ASA was administered did not affect baseline or peak PGF2 alpha concentrations. It was concluded that either the timing or route of administration of ASA resulted in the failure of ASA to effectively reduce peak peripheral PGF2 alpha concentrations.

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“…Balog and Hester (1991) reported that feeding .05% ASA decreased the incidence of shell-less eggs in aged layer breeders, but this dosage was not effective in causing a concomitant increase in hardshelled egg production. Long-term feeding of ASA at dosages of .025 to .200% to layer breeders for an entire production cycle had no effect on hard-shelled, soft-shelled, or shell-less egg production (McDaniel et al, 1993a). In fact, hens fed ASA (.025 to .400% of the diet) laid hard-shelled eggs of poorer shell quality than controls (McDaniel et al, 1993a).…”

Section: Introductionmentioning

confidence: 97%

“…Acetylsalicylic acid (ASA), the active ingredient of aspirin, has been evaluated as a potential feed ingredient of laying hen rations because of its antipyretic (Reid et al, 1964;Thomas et al, 1966;Oluyemi and Adebanjo, 1979) and antiprostaglandin (PG) properties (Balog and Hester, 1991;McDaniel et al, 1993a). Under conditions of high environmental temperatures, it was reasoned that the antipyretic properties of ASA would help alleviate the detrimental effects of heat stress on egg production and shell quality.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, ASA was fed to layer breeders to determine whether the improvement in egg production noted by Reid et al (1964), Thomas et al (1966), and Oluyemi and Adebanjo (1979) was due to its anti-PG properties rather than its antipyretic properties (Balog and Hester, 1991;Balog et al, 1993;McDaniel et al, 1993a). Because many eggs are laid prematurely, resulting in the production of eggs that are soft-shelled (partially calcified) or shell-less (little to no calcification), ASA may inhibit uterine production of PG, thereby preventing the premature oviposition of some of these defective eggs .…”

Section: Introductionmentioning

confidence: 99%

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Response of Layer Breeders to Dietary Acetylsalicylic Acid.

et al. 1993

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Acetylsalicylic acid (ASA), the active ingredient of aspirin, has been evaluated as a potential feed ingredient in laying hen rations because of its antipyretic and antiprostaglandin properties. Therefore, the present study was designed to determine whether dietary ASA or its metabolites are transferred to the egg.A single oral dose of 14 C-carboxyl-labeled ASA administered to White Leghorn hens resulted in eggs containing approximately .02% of the administered dose. More 14 C-label was found in the first egg laid than in subsequent eggs laid, and more 14 C-label was detected in the albumen than in the yolk when eggs were analyzed on an entire egg component basis. The distribution of the * 4 C-label changed markedly with each egg laid, as 96.5,33.5, and 12.0% of the radioactivity was present in the albumen in the first three eggs laid following dosing. Conversely, 3.5, 66.5, and 88.0% of the egg radioactivity was present in the yolk of the first three eggs laid postdosing. White Leghorn breeder hens fed .100, .200, and .400% ASA for an entire (13 mo) production cycle laid eggs containing measurable amounts of salicylic acid (SA, the major metabolite of ASA) in the albumen and yolk, with no detectable levels found in eggs of hens fed 0, .025, and .050% ASA. Again, more SA was detected in the albumen than in the yolk, when expressed either on a per gram or entire egg component basis, from hens fed .200 and .400% ASA. Thus, it appears that ASA can be fed to hens at dietary levels of .05% or lower for an entire production cycle without detectable accumulation (<5 ppm) of SA in the egg yolk or albumen.(

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Response of Layer Breeders to Dietary Acetylsalicylic Acid.

Cited by 22 publications

References 26 publications

Effect of indomethacin on hyperthermia induced by heat stress in broiler chickens

Effect of indomethacin on hyperthermia induced by heat stress in broiler chickens

Response of Layer Breeders to Dietary Acetylsalicylic Acid. 2. Effects on Circulating Concentrations of Prostaglandin F2α

Response of Layer Breeders to Dietary Acetylsalicylic Acid.

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