Response of lipogenesis and fatty acid synthetase to physical training and exhaustive exercise in rats

Abstract

The effect of physical training and exhaustive exercise on fatty acid synthesis in rat liver and adipose tissue has been investigated. Exercise training (treadmill running) significantly (p less than 0.05) decreased body wt, eipdidymal fat pad wt, adipocyte size, and hepatic fatty acid synthetase activity. Training did not significantly affect adipose tissue cell number, lipogenesis from glucose-U-14C, or fatty acid synthetase. Exercise to exhaustion immediately prior to sacrifice significantly (p less than 0.05) decreased lipogenesis from glucose-U-14C and fatty acid synthetase in adipose tissue from trained but not untrained rats. Liver fatty acid synthetase was not significantly influenced by exhaustive exercise. The results of this study indicate that rats may adapt to physical training by decreasing adipose tissue lipogenesis during exhaustive exercise. This adaptation in energy metabolism may facilitate physically trained animals in conserving blood glucose during exhaustive exercise, thereby prolonging endurance.

Combined effects of hypoxia and endurance training on lipid metabolism in rat skeletal muscle

“…The increase in MAV and CS activity and the decrease in BM are consistent with previous findings on the effect of endurance training in rats (Askew et al. 1975, Hoppeler et al.…”

Adipose Tissue Lipid Accumulation Pathways in Marathon Runners

“…These results are at variance with those of animal studies which have reported training effects only for insulin stimulated values (19,36). This could be due to the fact that each animal strain exhibits little genetic variation, but has a characteristic lipogenic activity (3,17). However, such is not the case with humans; each individual has a unique genetic profile such that the response to endurance training can be at variance with that observed in inbred rats.…”

Long-term exercise increases the DNA binding activity of peroxisome proliferator–activated receptor γ in rat adipose tissue

“…Askew et al [12] found decreased FAS activity in rat liver after exercise training and no difference in the adipose tissue. On the contrary, Faulconnier et al [13] found decreased activity of the enzyme in rat adipose tissue and no difference in the liver with exercise training.…”