Response of Sulfonamide-fast Pneumococci to Penicillin

Penicillin: Its Antibacterial Effect in Whole Blood and Serum for the Hemolytic Streptococcus and Staphylococcus Aureus 1

“…That such an observation should be made might have been predicted from the in vitro studies of the effect of penicillin in whole blood on a large inoculum of staphylococci. In view of the fact that Powell and Jamieson (12) and McKee and Rake (13) have demonstrated that sulfonamide-resistant pneumococci are readily susceptible to the action of penicillin, it would appear that the mechanism of antibacterial action of penicillin and that of the sulfonamide compounds are different. This suggests that a combination of sulfathiazole or sulfadiazine with penicillin might prove more effective than either compound alone in the treatment of staphylococcal infections.…”

The Inheritance of Environmentally Induced Characters in Bacteria

“…Finland (1941a, 1941b) reported the development of sulfonamide-resistant strains of Escherichia coli and Staphylococcus. That sulfonamide-resistant strains of pneumococci were as sensitive to the action of penicillin as was the non-"sulfa-fast" parent strain was reported by Powell and Jamieson (1942). Rammelkamp (1942) has noted increased resistance of Staphylococcus to tyrothricin.…”

The Absorption, Excretion, and Destruction of Orally Administered Penicillin 1

“…In addition to the above reports, Powell and Jamieson, and Libby (5,6) had noted that mice could be protected against lethal doses of pneumococci and other organisms by the administration of penicillin in the diet. Free and his associates (7) had also found that 8 to 33 per cent of a dose of 100,000 units of penicillin could be detected in the urine during the six hours immediately following ingestion.…”