Response of the temporomandibular joint tissue of rats to rheumatoid arthritis induction methods

Wang, Ding Han; Yang, Mu Chen; Hsu, Wun Eng; Hsu, Ming Lun; Yu, Ling Ming

doi:10.1016/j.jds.2016.12.001

Cited by 13 publications

(8 citation statements)

References 24 publications

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“…Regarding to the anatomy of TMJ, it can be simply separated to two cavities by articular disc, upper and lower cavities. There are two kinds of synovial lining cells (the macrophage‐like type A and fibroblast‐like type B cells) and each kind of cell plays different characteristic including involve in the immune response, produce collagen and fluids to effect smooth jaw movement [60,61]. Recently, more and more studies try to clarify the change of synovial fluid of TMJ with internal derangement.…”

Section: Etiologymentioning

confidence: 99%

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Functional disorders of the temporomandibular joints: Internal derangement of the temporomandibular joint

Chang

Wang

Yang

et al. 2018

The Kaohsiung J of Med Scie

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Temporomandibular joint (TMJ) is one of the most complex joints of the human body. Due to its unique movement, in terms of combination of rotation and translator movement, disc of the joint plays an important role to maintain its normal function. In order to sustain the normal function of the TMJ, disc must be kept in proper position as well as maintain normal shape in all circumstances. Once the disc is not any more in its normal position during function of the joint, disturbance of the joint can be occurred which will lead to subsequent distortion of the disc. Shape of the disc can be influenced by many factors i.e.: abnormal function or composition of the disc itself. Etiology of the internal derangement of the disc remains controversial. Multifactorial theory has been postulated in most of previous manuscripts. Disc is composed of mainly extracellular matrix. Abnormal proportion of collagen type I & III may also leads to joint hypermobility which may be also a predisposing factor of this disorder. Thus it can be recognized as local manifestation of a systemic disorder. Different treatment modalities with from conservative treatment to surgical intervention distinct success rate have been reported. Recently treatment with extracellular matrix injection becomes more and more popular to strengthen the joint itself. Since multifactorial in character, the best solution of the treatment modalities should be aimed to resolve possible etiology from different aspects. Team work may be indication to reach satisfied results.

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Section: Etiologymentioning

confidence: 99%

“…TMJ condyle could also be affected by these factors and result in condylar osteophytes or erosion. When these factors appears imbalance may associated with reduced TMJ internal derangement or even lead to TMJ bony structure change [55,61].…”

Section: Current Studies Of Tmjs With Internal Derangement and Destrumentioning

confidence: 99%

Functional disorders of the temporomandibular joints: Internal derangement of the temporomandibular joint

Chang

Wang

Yang

et al. 2018

The Kaohsiung J of Med Scie

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“…En tanto, las medidas M1, M6, M7 y M8 que permiten la localización del cóndilo mandibular pueden ser de utilidad en estudios relacionados con el estudio patofisiológico de la ATM (Herring, 2003). Tal es el caso de estudios sobre procesos degenerativos que afectan a articulación como la osteoartritis (Fuentes et al, 2017) o a los tejidos circundantes como la artritis reumatoidea (Wang et al, 2017). Estas medidas pueden resultar especialmente útiles a la hora de establecer y validar los modelos de estudio de dichas patologías.…”

Section: Discussionunclassified

Características Morfométricas de la Mandíbula de Rata: Un Estudio Radiológico de un Modelo Experimental Animal Ampliamente Utilizado a través de CBCT

et al. 2022

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RESUMEN: La mandíbula de rata es una de las estructuras anatómicas de mayor interés en la investigación en las ciencias odontológicas, esto debido a su similitud con la mandíbula humana. El objetivo de este estudio fue caracterizar morfometricamente la mandíbula de ratas mediante CBCT. Se analizó el examen cone beam de 20 ratas hembras, adultas sanas. Mediante el software del examen, fue posible aislar la mandíbula derecha e izquierda de las otras estructuras y realizar adecuadamente las medidas morfométricas de interés. En la comparación de ambos lados, sólo dos medidas presentaron diferencias significativas. La distancia entre el punto más profundo de la escotadura sigmoidea hasta el punto más profundo de la escotadura en el margen inferior de la mandíbula, fue mayor en el lado izquierdo que en el derecho. Y la distancia entre el punto más superior del cóndilo hasta la base mandibular, en la proyección perpendicular del plano mandibular fue mayor en el lado izquierdo que en el derecho. De acuerdo a las medidas obtenidas, podemos determinar que la mandíbula de la rata es una estructura alargada, con dimensiones mayores en sentido anteroposterior en comparación con las medidas verticales. El conocimiento de la anatomía de la mandíbula de rata y sus variaciones por lado permite a los investigadores tener referencias adecuadas para los estudios que involucren esta estructura, como por ejemplo, investigaciones que requieran la aplicación de técnicas anestésicas, estudio del dolor orofacial, estudio patofisiológico de la ATM, estudio del crecimiento óseo, testeo de biomateriales dentales o en el estudio de procesos fisiopatológicos relacionados con los tejidos dentales o periodontales. La mandíbula de la rata es un buen modelo animal debido a su reproducibilidad y bajo costo. La mandíbula derecha e izquierda son similares en sus dimensiones anteroposteriores, pero no las verticales.

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“…Acute TMJ Arthritis was established for evaluation of various treatment groups in vivo , based upon previous studies. 35 Briefly, thirty-six 8-week-old male SD rats were randomly divided into five groups: (1) Normal group (9 rats, 3 of which sacrificed on day 0, day 7 and day 14 respectively); (2) Saline group (9 rats, 3 of which sacrificed on day 0, day 7 and day 14 respectively); (3) 4-OI treated group (100 μg/mL; 6 rats, 3 of which sacrificed on day 7 and day 14 respectively); (4) Zn-NH-pyr treated group (equivalent to the concentration loaded with 100 μg/mL 4-OI; 6 rats, 3 of which sacrificed on day 7 and day 14 respectively); (5) 4-OI@Zn-NH-pyr treated group (equivalent to 100 μg/mL 4-OI; 6 rats, 3 of which sacrificed on day 7 and day 14 respectively). The emulsion of complete Freund's adjuvant (CFA, 5 mg/mL; 7023; Chondrex, Redmond, WA, USA) and Chick type II collagen (2 mg/mL; 20012; Chondrex, Redmond, WA, USA) was prepared in terms of the manufacturer's instructions.…”

Section: Methodsmentioning

confidence: 99%

Mitochondria-targeted supramolecular coordination container encapsulated with exogenous itaconate for synergistic therapy of joint inflammation

Chen¹,

Li²,

Cao³

et al. 2022

Theranostics

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Rationale: Inflammatory macrophages and osteoclasts (OCs) play critical roles in joint inflammation, which feature the excessive production of reactive oxygen species (ROS), resulting in synovial inflammation and bone erosion. Scavenging ROS, especially by modulating mitochondrial metabolic activity, could be a desirable strategy for the management of inflammatory joints. This study aimed to develop a mitochondria-targeted supramolecular drug delivery system with exogenous and endogenous ROS-scavenging activities for the treatment of joint inflammation. Methods: In this study, we utilized a zinc-based metal-organic supercontainer (MOSC) as a proton sponge and electron reservoir with outstanding proton binding capacity, extracellular ROS-scavenging ability, and biocompatibility to establish an efficient supramolecular nanocarrier for endo/lysosomal escape and mitochondrial targeting. 4-Octyl itaconate (4-OI), an itaconate derivative, served as the loaded guest for the construction of a synergistic therapeutic system for inflammatory macrophages and OCs. Results: After the effective encapsulation of 4-OI, 4-OI@Zn-NH-pyr not only exhibited potent ROS-scavenging capacity, but also reduced ROS production by mediating mitochondrial respiration in inflammatory macrophages. Regarding its anti-inflammatory efficacy, 4-OI@Zn-NH-pyr ameliorated the inflammatory reaction by activating nuclear factor erythroid 2-related factor 2 (Nrf2), thus increasing the production of antioxidants, apart from the inhibition of NF-κB pathways. Additionally, receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation and function was remarkably suppressed by 4-OI@Zn-NH-pyr. Consistent with in vitro observations, 4-OI@Zn-NH-pyr efficiently inhibited synovial inflammation and subchondral bone destruction in an acute arthritis model. Conclusion: By using MOSCs that are highly reactive to ROS as drug-loaded matrices for the first time, this study provides an avenue for the management of severe joint inflammation by designing synergistic supramolecular drug-delivery systems with subcellular targeting and ROS-scavenging capacity.

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Response of the temporomandibular joint tissue of rats to rheumatoid arthritis induction methods

Cited by 13 publications

References 24 publications

Functional disorders of the temporomandibular joints: Internal derangement of the temporomandibular joint

Functional disorders of the temporomandibular joints: Internal derangement of the temporomandibular joint

Características Morfométricas de la Mandíbula de Rata: Un Estudio Radiológico de un Modelo Experimental Animal Ampliamente Utilizado a través de CBCT

Mitochondria-targeted supramolecular coordination container encapsulated with exogenous itaconate for synergistic therapy of joint inflammation

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