Response rate and outcome of a novel first line therapy for advanced head and neck carcinomas: Chemo-radiochemotherapy (CRC)

Pre‐treatment haemoglobin level predicts response and survival after TPF induction polychemotherapy in advanced head and neck cancer patients

“…While high‐risk patients may benefit from more aggressive treatments, low‐risk patients may respond favourably to less intensive approaches 5 . New induction chemotherapy regimens such as TPF, consisting of docetaxel (T), cisplatin (P) and 5‐flurouracil (F) seem to be feasible and active in patients with SCCHN as reported in previous studies 3,6,7 . Furthermore, response to induction chemotherapy with TPF may predict subsequent radio‐sensitivity and may result in a reduced rate of distant metastasis 3,8 .…”

Malignome des Larynx

“…Aus diesem Grunde haben heutige Protokolle wieder die Induktionschemotherapie aufgegriffen (Laryngoprotect-Studie, GORTEC-Organerhaltprotokoll) [32][33][34]. Vorteile der Induktionsprotokolle bestehen in einer frühen Selektion der Responder und reduzierter Spättoxizität durch sequenzielle Bestrahlung.…”