Over recent years, nanotechnology's landscape has witnessed transformative advancements, heralding new research opportunities in scientific and engineering domains. A notable innovation in this evolution is the development of nanofluids, comprising nanoparticles (each under 100 nm in diameter) suspended in conventional heat transfer fluids such as ethylene glycol and water. Distinguished from traditional heat transfer fluids, nanofluids are posited to offer substantial enhancements, particularly in thermal characteristics. The dispersion of nanoparticles, even in minimal quantities, within base fluids markedly improves the thermal properties of these fluids. This study focuses on evaluating the thermal performance of a shell and tube heat exchanger utilizing the shear stress transport (SST) turbulence model. ANSYS CFX, acclaimed for its accuracy, robustness, and expedience in various turbulence models, is employed for this analysis. The SST model is particularly effective in non-equilibrium turbulent boundary layer flows, enabling accurate heat transfer predictions. ANSYS CFX's approach to near-wall equations mitigates the stringent grid resolution requirements often encountered in computational fluid dynamics (CFD) applications. The investigation encompasses the use of water and TiO 2 /water nanofluid at varying concentrations (1%, 2%, 3%, 4%, 5%) in a 3D model and CFD simulation. Enhanced efficiency and cooling performance are observed with the introduction of nanofluids in the shell and tube heat exchanger.