Response to angiotensin infusion before and after adrenalectomy in the rabbit

Oo, Akinkugbe; Wc, Brown; Wi, Cranston

doi:10.1152/ajplegacy.1967.212.5.1147

Cited by 7 publications

(5 citation statements)

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“…This was followed by studies by Smith [28] in Lagos, Akinkugbe et al [9] in Ibadan, Johnson [52] in Lagos, Oviasu et al [32][33][34][35] in Benin city and Oyediran in Epe near Lagos. Akinkugbe is generally regarded as the father and doyen of blood pressure and hypertension research in Nigeria because of his seminal work in this field in the late 60s and 70s [9,10,[53][54][55][56][57][58][59][60][61][62] . He documented that: (1) Systolic blood pressure rose with age in both sexes and in all age groups from 12-70 years.…”

Section: Historical Vignettementioning

confidence: 99%

Blood pressure, prevalence of hypertension and hypertension related complications in Nigerian Africans: A review

Ogah¹,

Okpechi²,

Chukwuonye³

et al. 2012

WJC

219

232

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To review studies on hypertension in Nigeria over the past five decades in terms of prevalence, awareness and treatment and complications. Following our search on Pubmed, African Journals Online and the World Health Organization Global cardiovascular infobase, 1060 related references were identified out of which 43 were found to be relevant for this review. The overall prevalence of hypertension in Nigeria ranges from 8%-46.4% depending on the study target population, type of measurement and cut-off value used for defining hypertension. The prevalence is similar in men and women (7.9%-50.2% vs 3.5%-68.8%, respectively) and in the urban (8.1%-42.0%) and rural setting (13.5%-46.4%). The pooled prevalence increased from 8.6% from the only study during the period from 1970-1979 to 22.5% (2000-2011). Awareness, treatment and control of hypertension were generally low with attendant high burden of hypertension related complications. In order to improve outcomes of cardiovascular disease in Africans, public health education to improve awareness of hypertension is required. Further epidemiological studies on hypertension are required to adequately understand and characterize the impact of hypertension in society.

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Section: Historical Vignettementioning

confidence: 99%

Blood pressure, prevalence of hypertension and hypertension related complications in Nigerian Africans: A review

Ogah¹,

Okpechi²,

Chukwuonye³

et al. 2012

WJC

219

232

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“…Adrenaline causes hyperglycaemia in humans, as does vasopressin (Karp et al, 1968). Angiotensin II can cause hyperglycaemia in humans (Ajzen et al, 1968), dogs (Heidenreich & Kook, 1963) and rabbits (Akinkugbe et al, 1967).…”

Section: Significance Ofhormone Actions On the Livermentioning

confidence: 99%

“…Another vasoactive agent which has been reported to cause hyperglycaemia, in rabbits (Akinkugbe et al, 1967), dogs (Heidenreich & Kook, 1963) and man (Ajzen et al, 1968) is angiotensin II, the peptide produced as a result of renin action (for reviews, see Laragh & Sealey, 1973;Regoli et al, 1974). The biochemical effects of angiotensin II have not been well documented (Allman, 1974).…”

mentioning

confidence: 99%

Glycogen phosphorylase, glucose output and vasoconstriction in the perfused rat liver. Concentration-dependence of actions of adrenaline, vasopressin and angiotensin II

Hems

Rodrigues

Whitton

1976

Biochemical Journal

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1. Glycogen phosphorylase (a form, in rapidly freeze-clamped samples) and glucose release were measured in the perfused liver, in response to a range of concentrations of adrenaline, [8-arginine]vasopressin (anti-diuretic hormone) and angiotensin II. 2. All three hormones increased phosphorylase a activity by about 10 mumol/min per g of fresh liver, which was more than sufficient to explain concomitant glucose release (1-2mumol/min per g). 3. Minimally effective concentrations which activated phosphorylase were: adrenaline, 10nM (2ng/ml); vasopressin, 40pM (40pg/ml, 15 muunits/ml); angiotensin II, 60pM (60pg/ml). 4. Glycogen synthase activity was inhibited by adrenaline and vasopressin but not significantly by angiotensin II. 5. Vasoconstriction observed with adrenaline and angiotensin II (but not vasopressin) might explain part of the activation of phosphorylase, since equivalent vasoconstriction (in separate perfusions) activated phosphorylase, did not stimulate glucose output or inhibit synthase. 6. The potency of these effects suggests that all three hormones can stimulate hepatic glycogen degradation in vivo (by direct hepatic action). It is proposed that hormones, and ischaemia, stimulate glycogen degradation to provide glucose phosphates for disposal within the liver cell, as well as for release as free gluose.

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“…Much of the earlier work on Ang II and substrate metabolism demonstrated regulation through sympathetic nervous system [ 5 , 6 ]. The review article by Shanks and Ramchandra provides significant, complementary insights to the contributions of Ang II to the regulation of hypertension and cardiovascular hemodynamics via activation of the parasympathetic nervous system (PNS) [ 7 ].…”

Section: Review: Ang II and Pns—novel Neural Insightsmentioning

confidence: 99%

“…The planning for the first special issue started just before the height of the pandemic, which helped to bring the significance of the Renin-Angiotensin-Aldosterone System (RAAS) in disease to the forefront during the pandemic. Independent of the recent pandemic, angiotensin II (Ang II) has long been well-recognized for contributing to substrate metabolism [ 1 , 2 , 3 , 4 ] primarily through sympathetic nerve activity [ 5 , 6 ]. These initial references demonstrate the potential significance of the RAAS to the regulation of basic (non-pathological) biological processes.…”

mentioning

confidence: 99%

The Renin-Angiotensin-Aldosterone System in Metabolic Diseases and Other Pathologies

Ortiz

Satou

Zhuo

et al. 2023

IJMS

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Response to angiotensin infusion before and after adrenalectomy in the rabbit

Cited by 7 publications

References 0 publications

Blood pressure, prevalence of hypertension and hypertension related complications in Nigerian Africans: A review

Blood pressure, prevalence of hypertension and hypertension related complications in Nigerian Africans: A review

Glycogen phosphorylase, glucose output and vasoconstriction in the perfused rat liver. Concentration-dependence of actions of adrenaline, vasopressin and angiotensin II

The Renin-Angiotensin-Aldosterone System in Metabolic Diseases and Other Pathologies

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