Response to Comment on Almurdhi et al. Reduced Lower-Limb Muscle Strength and Volume in Patients With Type 2 Diabetes in Relation to Neuropathy, Intramuscular Fat, and Vitamin D Levels. Diabetes Care 2016;39:441–447

Almurdhi, Monirah M; Reeves, Neil D.; Bowling, Frank L.; Boulton, Andrew J.M.; Jeziorska, Maria; Malik, Rayaz A.

doi:10.2337/dci16-0020

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…Previous studies have shown that testosterone reduces the occurrence of sarcopenia by stimulating cellular metabolism and survival pathways and inhibiting death pathways 20 . This study did not see the effect of diabetic complications on DMS, but studies have shown that muscle strength in type 2 diabetes is associated with the severity of diabetic peripheral neuropathy 21 .…”

Section: Discussionmentioning

confidence: 63%

Vitamin D Level as a Predictor of Dysmobility Syndrome in Middle-aged and older adults with Type 2 Diabetes

Ma,

Liu,

Yin

et al. 2023

Preprint

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This cross-sectional study aimed to explore the effect of 25-(OH) Vit D on Dysmobility Syndrome (DMS)in type 2 diabetes mellitus(T2DM) patients, including 330 patients (66.96±8.78 years old) with T2DM who were admitted to the Qinhuangdao First Hospital from October 2020 to February 2022. The 25-(OH) Vit D is grouped at the 25th percentile into two groups (group A <36.2nmol/L, group B ≥ 36.2nmol/L). Data on grip strength, six meters grip strength, and level of 25-(OH) vitamin D were collected and measure bone mineral density (BMD) by Dual-energy X-ray (DXA). The incidence of DMS in patients with T2DM was 25.5%. The proportion of vitamin deficiency is 67.9% in patients with T2DM. Compared with patients without DMS, the level of 25-(OH)Vit D in patients with DMS was lower (41.74±14.60 vs 47.19±13.01, P＜0.05). With DMS as the dependent variable, Gender, age, vitamin D level, HbA1c, ALB, HDLC, eGFR, Diabetic retinopathy, diabetes nephropathy, and diabetes peripheral neuropathy were taken as independent variables, and logistic regression analysis was performed to find the independent factors, which include age (OR value=1.175，95%CI：1.110-1.243, P=0.000), low levels of 25-(OH) Vit D (OR value=2.910，95%CI：1.357-6.242, P=0.006), and higher levels of HbA1c(OR value=1.288, 95%CI: 1.085-1.529, P=0.004), they are associated with the risk of DMS’s prevalence in T2DM patients. But males reduce the risk of DMS by 51.3% (OR value=0.487, 95%CI: 0.238-0.998, P=0.05).

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Section: Discussionmentioning

confidence: 63%

Vitamin D Level as a Predictor of Dysmobility Syndrome in Middle-aged and older adults with Type 2 Diabetes

Ma,

Liu,

Yin

et al. 2023

Preprint

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The myokine CCL5 recruits subcutaneous preadipocytes and promotes intramuscular fat deposition in obese mice

Yu,

Yao,

et al. 2024

American Journal of Physiology-Cell Physiology

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Intramuscular fat (IMF) refers to the lipid stored in skeletal muscle tissue. The number and size of intramuscular adipocytes are the primary factors that regulate IMF content. Intramuscular adipocytes can be derived from either in situ or ectopic migration. In this study, it was discovered that the regulation of IMF levels is achieved through the chemokine (C-C motif) ligand 5 (CCL5)/chemokine (C-C motif) receptor 5 (CCR5) pathway by modulating adipocyte migration. In coculture experiments, C2C12 myotubes were more effective in promoting the migration of 3T3-L1 preadipocytes than C2C12 myoblasts, along with increasing CCL5. Correspondingly, overexpressing the CCR5, one of the receptors of CCL5, in 3T3-L1 preadipocytes facilitated their migration. Conversely, the application of the CCL5/CCR5 inhibitor, MARAVIROC (MVC), reduced this migration. In vivo, transplanted experiments of subcutaneous adipose tissue (SCAT) from transgenic mice expressing green fluorescent protein (GFP) provided evidence that injecting recombinant CCL5 (rCCL5) into skeletal muscle promotes the migration of subcutaneous adipocytes to the skeletal muscle. The level of CCL5 in skeletal muscle increased with obesity. Blocking the CCL5/CCR5 axis by MVC inhibited IMF deposition, whereas elevated skeletal muscle CCL5 promoted IMF deposition in obese mice. These results establish a link between the IMF and the CCL5/CCR5 pathway, which could have a potential application for modulating IMF through adipocyte migration.

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Response to Comment on Almurdhi et al. Reduced Lower-Limb Muscle Strength and Volume in Patients With Type 2 Diabetes in Relation to Neuropathy, Intramuscular Fat, and Vitamin D Levels. Diabetes Care 2016;39:441–447

Cited by 2 publications

References 6 publications

Vitamin D Level as a Predictor of Dysmobility Syndrome in Middle-aged and older adults with Type 2 Diabetes

Vitamin D Level as a Predictor of Dysmobility Syndrome in Middle-aged and older adults with Type 2 Diabetes

The myokine CCL5 recruits subcutaneous preadipocytes and promotes intramuscular fat deposition in obese mice

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