Response to Commentary on “The neuroinvasive potential of SARS‐CoV‐2 may play a role in the respiratory failure of COVID‐19 patients”

Abstract

In a recent review, we have suggested a neuroinvasive potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its possible role in the causation of acute respiratory failure of coronavirus disease 2019 (COVID-19) patients (J Med Viol doi: 10.1002/jmv.25728), based upon the clinical and experimental data available on the past SARS-CoV-1 and the recent SARS-CoV-2 pandemic. In this article, we provide new evidence recently reported regarding the neurotropic potential of

Brainstem Dysfunction in SARS-COV2 Infection Can Be a Potential Cause of Respiratory Distress

“…Coronaviruses (CoVs) commonly cause enteric and respiratory diseases in animals and humans. 10,17,18 .…”

Sudden and Complete Olfactory Loss of Function as a Possible Symptom of COVID-19

“…Most coronaviruses share a similar structure and infection pathway; thus, one can expect the similar infection mechanisms for SARS-CoV-2. 4 Coronaviruses could invade the brain via the cribriform plate close to the olfactory bulb and the olfactory epithelium. We could expect some structural changes in the olfactory bulb that were not observed in this case.…”

Hypoxemia in COVID‐19; Comment on: “The neuroinvasive potential of SARS‐CoV2 may play a role in the respiratory failure of COVID‐19 patients”

“…SARS‐CoV‐2 is a β‐coronavirus , like HCoV‐OC43 and SARS‐CoV, to which is structurally homologous. These viruses are potentially neuroinvasive 2 ; hence, the neuroinvasive potential of SARS‐CoV‐2 is probable. The olfactory disturbances common of COVID‐19 can be due to virus‐induced neuronal damage in the olfactory bulb 9 .…”