Response to different measles vaccine strains given by aerosol and subcutaneous routes to schoolchildren: a randomised trial

Dilraj, Athmanundh; Cutts, Felicity; Castro, J Fernández de; Wheeler, Jeremy G; Brown, David; Roth, Cathy; Coovadia, Hoosen; Bennett, John V.

doi:10.1016/s0140-6736(99)95140-1

Cited by 141 publications

(73 citation statements)

References 22 publications

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“…1, 4, and 6; Table I). These observations are in line with results previously collected with inhaled attenuated measles and inactivated influenza vaccines in preliminary clinical trials as well as with protection studies carried out in mice with Yersinia pestis F1 and V subunit vaccines co-encapsulated in polylactide microspheres (3)(4)(5)(6)(7). We extended these previous results to naked DNA vaccines and additionally supported the safety of vaccine delivery to the lung by direct analysis of the lung tissue.…”

Section: Discussionsupporting

confidence: 89%

“…In light of the correlation between IgG titers in BAL and serum (Fig. 3), it also remains to be determined if the reported improved protection of inhaled over injected vaccines in clinical trials resulted from actual enhanced defenses at the mucosa and/or from a global increase in immunity (3)(4)(5).…”

Section: Discussionmentioning

confidence: 99%

“…Pulmonary administration of vaccines appears particularly promising because, in contrast to other mucosal surfaces, the lung contains a highly responsive immune system (3)(4)(5)(6)(7). Efficacious and safe immunization by inhalation of vaccines has been demonstrated in a few cases over the past 40 years.…”

Section: Introductionmentioning

confidence: 99%

“…Efficacious and safe immunization by inhalation of vaccines has been demonstrated in a few cases over the past 40 years. Several investigators reported that inhaled attenuated measles virus vaccine produced higher seroconversion rates, higher antibody titers, better antibody persistence, increased protection, and less clinical side effects such as fever, rash, rhinitis, cough, and headache in infants and children than vaccination by the subcutaneous route or by nasal instillation (3,4,7). Preliminary human trials of inhaled inactivated influenza virus vaccine achieved identical outcomes (5).…”

Section: Introductionmentioning

confidence: 99%

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Local and Systemic Immune Responses to Intratracheal Instillation of Antigen and DNA Vaccines in Mice

Lombry

Marteleur

Arras³

et al. 2004

Pharm Res

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Purpose. The purpose of this study was to determine the immunization efficacy of antigen and DNA vaccines after delivery to the lung, to assess the integrity of the pulmonary tissue after vaccination, and to elucidate mechanisms involved in the induction of immunity. Methods. Ovalbumin, the plasmid encoding ovalbumin, the hepatitis B surface antigen (HBsAg), or plasmid encoding HBsAg were intratracheally instilled or injected in quadriceps in mice. The immune response and its Th polarization were analyzed over time. Markers of inflammation were measured in bronchoalveolar lavage, and lung histology was performed. The fate of ovalbumin following intratracheal instillation was studied. Results. According to the vaccine, the pulmonary route produced stronger or equivalent humoral and cellular responses systemically and locally in the lung as compared to injection. The IgG subclasses and cytokine pattern indicate that the immunity was preferentially polarized toward the Th2 and Th1 type for antigen and DNA immunization, respectively. Ovalbumin penetrated the respiratory tissue and blood poorly after intratracheal instillation, suggesting that the immune response was triggered at airway surfaces. Overall, vaccines delivered to the lung did not induce any local sign of inflammation. Conclusions. Pulmonary administration of vaccines might be a promising alternative to conventional vaccination by injection.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Local and Systemic Immune Responses to Intratracheal Instillation of Antigen and DNA Vaccines in Mice

Lombry

Marteleur

Arras³

et al. 2004

Pharm Res

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“…21 Therefore, it can be employed for priming for parenteral immunization and aiding booster administrations. 17,22,23 If required, the mucosal route can administer a greater volume of vaccine. 16 This route can also be employed to administer combined antigens such as Measles and Rubella: studies have shown that there is no interference between antigens, instead, it is likely to elicit superior mucosal immunity for both.…”

Section: Discussionmentioning

confidence: 99%

A Meta-Analysis of Studies Comparing the Respiratory Route with the Subcutaneous Route of Measles Vaccine Administration

Hiremath

Omer

2005

Human Vaccines

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The respiratory tract has been suggested as an optimal alternative site to target measles vaccine delivery. We performed a meta-analysis to evaluate the efficacy of measles vaccine administered through the respiratory route compared to the subcutaneous route. We analyzed 20 reported results from 16 eligible studies. Seroresponse was 4% higher amongst vaccinees in the respiratory group compared to the subcutaneous group (M-H pooled RR = 1.04; 95% CI = 0.98-1.10). For vaccinees over 9 months of age, seroresponse was 15% higher in the respiratory group (M-H pooled RR = 1.15; 95% CI = 1.08 to 1.17). When Edmonston Zagreb (EZ) strain was used, the vaccine was found to be neither more nor less efficacious when administered through respiratory route (M-H pooled RR=1.00; 95% CI = 0.94 to 1.08). Seroresponse in the vaccinees receiving aerosol measles vaccine was 10% higher (M-H pooled RR = 1.10, 95% CI = 1.04-1.17) compared to those who received measles vaccine through the subcutaneous route. Seroresponse due to aerosolized EZ vaccine was 9% higher than subcutaneous EZ vaccine (M-H pooled RR = 1.09; 95% CI = 1.02-1.16). The seroresponse among seropositive vaccinees was 60% higher (M-H RR = 1.60; 95% CI = 1.40 to 1.80). The results suggest that the respiratory route of delivery of measles vaccine is at least as efficacious as measles vaccine administered through the subcutaneous route. However, more research is required on standardization of dosage, administration equipments, efficacy, and safety of respiratory (aerosol) route of administration of measles vaccine.

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Measles Aerosol Vaccination

Valdespino-Gómez¹,

García-García

Fernandez-de-Castro

et al. 2006

Current Topics in Microbiology and Immunology

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Response to different measles vaccine strains given by aerosol and subcutaneous routes to schoolchildren: a randomised trial

Cited by 141 publications

References 22 publications

Local and Systemic Immune Responses to Intratracheal Instillation of Antigen and DNA Vaccines in Mice

Local and Systemic Immune Responses to Intratracheal Instillation of Antigen and DNA Vaccines in Mice

A Meta-Analysis of Studies Comparing the Respiratory Route with the Subcutaneous Route of Measles Vaccine Administration

Measles Aerosol Vaccination

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