Response to letter: Carbon fibre reinforced PEEK versus traditional metallic implants for orthopaedic trauma surgery: A systematic review

Theivendran, Kanthan; Arshad, Faizan; Hanif, Umar-Khetaab; Reito, Aleksi; Foote, Clary J

doi:10.1016/j.jcot.2022.101779

Cited by 1 publication

(1 citation statement)

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“…For these reasons, efforts have already been made to either adapt the mechanical properties of the metallic implants to those of the bone by investigating other alloys [ 12 , 13 , 14 ] or, for example, by foaming the material [ 15 ]. Efforts are also underway to replace the metallic materials entirely with other materials, such as polymeric composites [ 16 ] or carbon-fiber-reinforced composites [ 17 , 18 ]. Thus, the search for biodegradable material has the greatest relevance, so that a second surgical intervention can be avoided and the material will degrade in the body after a certain time [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of 3D Printing Parameters on the Mechanical Stability of PCL Scaffolds and the Proliferation Behavior of Bone Cells

et al. 2022

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Introduction The use of scaffolds in tissue engineering is becoming increasingly important as solutions need to be found for the problem of preserving human tissue, such as bone or cartilage. In this work, scaffolds were printed from the biomaterial known as polycaprolactone (PCL) on a 3D Bioplotter. Both the external and internal geometry were varied to investigate their influence on mechanical stability and biocompatibility. Materials and Methods: An Envisiontec 3D Bioplotter was used to fabricate the scaffolds. First, square scaffolds were printed with variations in the strand width and strand spacing. Then, the filling structure was varied: either lines, waves, and honeycombs were used. This was followed by variation in the outer shape, produced as either a square, hexagon, octagon, or circle. Finally, the internal and external geometry was varied. To improve interaction with the cells, the printed PCL scaffolds were coated with type-I collagen. MG-63 cells were then cultured on the scaffolds and various tests were performed to investigate the biocompatibility of the scaffolds. Results: With increasing strand thickness and strand spacing, the compressive strengths decreased from 86.18 + 2.34 MPa (200 µm) to 46.38 + 0.52 MPa (600 µm). The circle was the outer shape with the highest compressive strength of 76.07 + 1.49 MPa, compared to the octagon, which had the lowest value of 52.96 ± 0.98 MPa. Varying the external shape (toward roundness) geometry, as well as the filling configuration, resulted in the highest values of compressive strength for the round specimens with honeycomb filling, which had a value of 91.4 + 1.4 MPa. In the biocompatibility tests, the round specimens with honeycomb filling also showed the highest cell count per mm², with 1591 ± 239 live cells/mm2 after 10 days and the highest value in cell proliferation, but with minimal cytotoxic effects (9.19 ± 2.47% after 3 days).

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