Response to Role of a 12‐Lead Electrocardiogram in the Diagnosis of Cardiac Tamponade as Diagnosed by Transthoracic Echocardiography in Patients With Malignant Pericardial Effusion

Khalid, Nauman; Chhabra, Lovely; Spodick, DSc David H.

doi:10.1002/clc.22416

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“…This study showed that 21.3% (46/216) of patients had evidence of electrical alternans. And other studies have shown that electrocardiographic evidence of electrical alternation has lower sensitivity in the diagnosis of pericardial effusion [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Prognosis and role of clinical and imaging features in patients with malignant pericardial effusion: a single-center study in China

Wang

Zhao

Wang

et al. 2021

BMC Cardiovasc Disord

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Background The diagnosis of malignant pericardial effusion (MPE) is often associated with a poor prognosis, but due to the complexity and unspecific nature of MPE patients' clinical manifestations, imaging often performs an essential role in diagnosis and prognosis. Methods Patients diagnosed with MPE between 2013 and 2018 at one tumor hospital were included and followed up. The data covered the basic clinical features, imaging findings, treatments and prognosis of patients with MPE, and the factors that may have affected the prognosis were explored. Results A total of 216 patients with MPE were included with the median age of 60 years. The most common primary cancer type was lung cancer (73.6%), the most common symptom was dyspnea (62.9%) and the most common abnormal electrocardiogram finding was sinus tachycardia (42.1%). The median survival time of the 216 patients with MPE was 13.7 months. The factors affecting prognosis were echocardiographic fluid signs (HR = 2.37, P = 0.010), electrocardiographic evidence of sinus tachycardia (HR = 1.76, P = 0.006) and echocardiographic evidence of cardiac tamponade (HR = 3.33, P < 0.001). Conclusions MPE has complex clinical manifestations and an unsatisfactory prognosis. Echocardiographic fluid signs, electrocardiographic evidence of sinus tachycardia, and echocardiographic evidence of cardiac tamponade are independent risk factors affecting prognosis.

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Section: Discussionmentioning

confidence: 99%