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The prevalence of atrial fibrillation (AF) is estimated at more than 3% in the adult population and there has been increased interest in screening for AF. In the SAFETY trial we chose to evaluate if inexpensive, wearable, consumer electrocardiography (ECG) sensing devices (Polar-H7 [PH7] and Firstbeat Bodyguard 2 [BG2]), could be used to detect AF accurately. We undertook a case-control study of 418 participants aged >65 (82 with AF and/or flutter at the study visit and 336 without) attending 3 general practice surgeries in Hampshire, UK for a single screening visit. The PH7 and BG2 devices were tested alongside 2 established AF detection devices (AliveCor and WatchBP) in random order and the diagnosis of AF was confirmed by 12-Lead ECG interpreted by a panel of cardiologists. The sensitivity (95% confidence interval [CI] range), specificity (95% CI range), and overall accuracy (95% CI range) of the 4 devices were: AliveCor: 87.8% (78.7% to 94.0%), 98.8% (97.0% to 99.7%), 96.7% (94.4% to 98.2%); WatchBP: 96.3% (89.7% to 99.2%), 93.5% (90.3% to 95.9%), 94.0% (91.3% to 96.1%): PH7: 96.3% (89.7% to 99.2%), 98.2% (96.2% to 99.3%), 97.9% (96.0% to 99.0%). BG2: 96.3% (89.7% to 99.2%), 98.5% (96.6% to 99.5%), 98.1% (96.3% to 99.2%). The PH7 and BG2 devices were highly reliable (the devices acquired sufficient data and obtained a diagnostic result in all but 1 participant on the first attempt). In conclusion, inexpensive, consumer heart rate monitoring devices (PH7 and BG2) can be used to detect AF accurately with sensitivity and specificity>95%. The consumer devices performed as well or better than WatchBP and AliveCor and have the capability to store or transmit ECG data which could be used to confirm AF.
The prevalence of atrial fibrillation (AF) is estimated at more than 3% in the adult population and there has been increased interest in screening for AF. In the SAFETY trial we chose to evaluate if inexpensive, wearable, consumer electrocardiography (ECG) sensing devices (Polar-H7 [PH7] and Firstbeat Bodyguard 2 [BG2]), could be used to detect AF accurately. We undertook a case-control study of 418 participants aged >65 (82 with AF and/or flutter at the study visit and 336 without) attending 3 general practice surgeries in Hampshire, UK for a single screening visit. The PH7 and BG2 devices were tested alongside 2 established AF detection devices (AliveCor and WatchBP) in random order and the diagnosis of AF was confirmed by 12-Lead ECG interpreted by a panel of cardiologists. The sensitivity (95% confidence interval [CI] range), specificity (95% CI range), and overall accuracy (95% CI range) of the 4 devices were: AliveCor: 87.8% (78.7% to 94.0%), 98.8% (97.0% to 99.7%), 96.7% (94.4% to 98.2%); WatchBP: 96.3% (89.7% to 99.2%), 93.5% (90.3% to 95.9%), 94.0% (91.3% to 96.1%): PH7: 96.3% (89.7% to 99.2%), 98.2% (96.2% to 99.3%), 97.9% (96.0% to 99.0%). BG2: 96.3% (89.7% to 99.2%), 98.5% (96.6% to 99.5%), 98.1% (96.3% to 99.2%). The PH7 and BG2 devices were highly reliable (the devices acquired sufficient data and obtained a diagnostic result in all but 1 participant on the first attempt). In conclusion, inexpensive, consumer heart rate monitoring devices (PH7 and BG2) can be used to detect AF accurately with sensitivity and specificity>95%. The consumer devices performed as well or better than WatchBP and AliveCor and have the capability to store or transmit ECG data which could be used to confirm AF.
One of the key open questions in extragalactic astronomy is what stops star formation in galaxies. While it is clear that the cold gas reservoir, which fuels the formation of new stars, must be affected first, how this happens and what are the dominant physical mechanisms involved is still a matter of debate. At least for satellite galaxies, it is generally accepted that internal processes alone cannot be responsible for fully quenching their star formation, but that environment should play an important, if not dominant, role. In nearby clusters, we see examples of cold gas being removed from the star-forming discs of galaxies moving through the intracluster medium, but whether active stripping is widespread and/or necessary to halt star formation in satellites, or quenching is just a consequence of the inability of these galaxies to replenish their cold gas reservoirs, remains unclear. In this work, we review the current status of environmental studies of cold gas in star-forming satellites in the local Universe from an observational perspective, focusing on the evidence for a physical link between cold gas stripping and quenching of the star formation. We find that stripping of cold gas is ubiquitous in satellite galaxies in both group and cluster environments. While hydrodynamical mechanisms such as ram pressure are important, the emerging picture across the full range of dark matter halos and stellar masses is a complex one, where different physical mechanisms may act simultaneously and cannot always be easily separated. Most importantly, we show that stripping does not always lead to full quenching, as only a fraction of the cold gas reservoir might be affected at the first pericentre passage. We argue that this is a key point to reconcile apparent tensions between statistical and detailed analyses of satellite galaxies, as well as disagreements between various estimates of quenching timescales. We conclude by highlighting several outstanding questions where we expect to see substantial progress in the coming decades, thanks to the advent of the Square Kilometre Array and its precursors, as well as the next-generation optical and millimeter facilities.
This article presents an up-dated analysis of synthetic optical and UV emission lines of simulated galaxies over cosmic time. The strong emission lines are derived from self-consistently coupling novel spectral models accounting for nebular emission from young stars, AGN and Post-AGB stars to cosmological zoom-in as well as large-scale simulations. Investigating the evolution of optical line-ratios in the BPT diagrams, the simulations can successfully reproduce the observed trend of [OIII]/Hβ ratio increasing from low to high redshifts, due to evolving star formation rate and gas metallicity. Standard selection criteria in the BPT diagrams can appropriately distinguish the main ionising source(s) of galaxies at low redshifts, but they are less reliable for metal-poor galaxies, dominating the early Universe. To robustly classify the ionising radiation of such metal-poor galaxies, diagnostic diagrams based on luminosity ratios of UV lines are discussed. The novel interface between simulations and observations is potentially important for the interpretation of high-quality spectra of very distant galaxies to be gathered by next-generation telescopes, such as the James Webb Space Telescope.
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