Responses of an identified dopamine-containing neurone to iontophoretically applied drugs

Logan, S.D.; Cottrell, G. A.

doi:10.1016/0028-3908(75)90028-3

Cited by 8 publications

(1 citation statement)

References 7 publications

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“…The physiological calcium levels are higher for invertebrate systems compared to mammalian systems. The dissection procedure and the identification of the dopamine containing neuron were described previously (Berry, 1972;Logan and Cottrell, 1975;Loker et al, 1975;Osborne et al, 1975;Lichtensteiger, 1979;Chien et al, 1988;Steiner and Felix, 1989). Snail shells were smashed before snails were pinned with the ventral side uppermost in a wax-filled Petri dish.…”

Section: Methodsmentioning

confidence: 99%

Observation and quantitation of exocytosis from the cell body of a fully developed neuron in Planorbis corneus

et al. 1995

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We have discovered a neuronal system that releases neurotransmitter via exocytosis from the cell body. In the large dopamine cell of the pond snail Planorbis corneus, depolarization induces rhythmic release of dopamine from the cell body. When a stimulant is applied extracellularly or intracellularly in situ to the cell body, transient dopamine concentration packets that appear in a bursting pattern are observed. Dopamine release is calcium dependent and release is on the time scale expected for exocytosis (2 to 4 msec rise times). Quantitation of individual events reveals an average of 818,000 molecules per exocytotic event. As many as 89,000 individual exocytotic events have been observed following a single stimulation of one cell. Neurotransmitter exocytosis from the neuronal cell body appears to represent an alternative form of neurocommunication to synaptic transmission.

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