Responses of antioxidant system to acute and trained exercise in rat heart subcellular fractions

Somani, Satu M.; Frank, Stuart; Rybak, Leonard P.

doi:10.1016/0091-3057(94)00427-k

Cited by 115 publications

(95 citation statements)

References 35 publications

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“…The increase in GSH (Figure 1), observed in many other studies (Ji et al, 1991;Somani et al, 1995;Elosua et al, 2003) can be explained as an adaptation-compensation response to an increase in ROS production. In turn, the latter were increased as a result of a greater consumption of oxygen by the electronic transport chain during the training.…”

Section: Discussionmentioning

confidence: 88%

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Effects of an aerobic training program on oxidative stress biomarkers in bulls

Escribano¹,

Túnez²,

Requena³

et al. 2010

Vet. Med. - Czech

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ABSTRACT:The aim of this study was to evaluate the effect of aerobic training (16 weeks -T1 and 24 weeks -T2) on oxidative stress biomarkers. To this end, GSH, GSH-peroxidase (GSH-Px) and catalase (CAT) activity were analysed in plasma. Nine bulls (3-4 years), were included in this work. The exercise training protocol was performed in a track ("taurodromo") three days per week for 24 weeks and consisted of 400 m warming up, 1200 m to 4-5 m/s, two minutes' resting, 1200 m to 4-5 m/s and, finally, 400 m walking. The results reflected that GSH-Px activity was higher at T1 (6.18 ± 0.45) than at baseline (T0; 2.31 ± 0.08) while the GSH level (2.98 ± 0.37) was lower vs. T0 (14.59 ± 3.40). Moreover, there were significant increases in GSH-Px (18.23 ± 1.36) and CAT (2.52 ± 0.04) activities and the recovery of basal values in GSH (11.75 ± 2.84) in T2. In conclusion, the type of training carried out in this study involved two well-defined stages: (i) a period of perturbation, followed by (ii) adaptation. The former stage was characterised by the induction of oxidative stress manifested as a decrease in the GSH, and the latter (T2) by the recovery of this non-enzymatic antioxidant.

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Section: Discussionmentioning

confidence: 88%

“…Meister and Anderson (1983), Kretschmar and Muller (1993), Ji (1995), Somani et al (1995), Ji and Leeuwenburgh (1996) and Powers et al (1999) have related the decreases in GSH to the existence of oxidative damage.…”

Section: Discussionmentioning

confidence: 99%

Effects of an aerobic training program on oxidative stress biomarkers in bulls

Escribano¹,

Túnez²,

Requena³

et al. 2010

Vet. Med. - Czech

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“…One of several mechanisms affected in old age is the impairment of self-defense system against reactive oxygen species (ROS) related to an imbalance between the prooxidants and antioxidants (Somani et al, 1995). However, ROS injury is felt largely in tissues with post-mitotic cells (Miquel, 1998).…”

Section: Introductionmentioning

confidence: 99%

Swim exercise training and adaptations in the antioxidant defense system of myocardium of old rats: relationship to swim intensity and duration

Kiran

Subramanyam

Devi

2004

Comparative Biochemistry and Physiology Part B: Biochemistry an

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We examined a suitable swim program of different intensities and durations that could evoke changes in the myocardial antioxidant capacity in 22-month-old rats. Male rats (Rattus norvegicus) were assigned to either a sedentary control (SE-C) group or one of six trainee groups. Animals were swim-exercised for 4 weeks with either 20 min or 40 miny day, and three intensities, low, moderate and high. Low-intensity at 20 minyday elicited maximum swim velocity (S ) v and endurance capacity (P-0.05). While serum total cholesterol, triglyceride and low-density lipoprotein (LDL-C) levels were significantly reduced, high-density lipoprotein (HDL-C) showed an increase (P-0.05) in low-intensity trained rats (20 minyday) over SE-C. Notable reduction in blood lactate was also evident. Exercise training significantly increased superoxide dismutase (Mn-SOD), decreased lipid peroxidation products, malondialdehyde and lipofuscin in the left and right ventricles. Increased Mn-SOD with concomitant decrease in lipofuscin in left ventricle was significantly greater than in right ventricle. Moderate-to high-intensity exercise was not effective in either reducing lipid peroxidation products or elevating Mn-SOD activity. These data suggest that swim training at low-intensity of 20 minyday is beneficial as a major protective adaptation against oxidative stress in old myocardium. ᮊ

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“…It is widely assumed that oxidative stress is detrimental to exercise performance, but there is little experimental evidence to support this data. Although antioxidant supplementation has been shown to decrease exerciseinduced oxidative stress in humans [5,37], there is no convincing experimental evidence that this is accompanied by an increase in exercise performance in healthy human subjects [15,18,33]. One limitation of the present study was that calculation of VO2max during the training period was not controlled.…”

Section: Discussionmentioning

confidence: 80%