Responses of erythroid cells to different neurotic influences

Дыгай, А. М.; Суслов, Н. И.; Скурихин, Е. Г.; Чурин, А. А.

doi:10.1007/bf02766433

Cited by 9 publications

(7 citation statements)

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“…Experimental neuroses are always accompanied by changes in the erythron system [4]. Individual components of the system responsible for local regulation of the erythron underwent changes in a conflict situation (CS) and during paradoxical sleep deprivation (PSD) [3].…”

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confidence: 99%

Mechanisms of Regulation of Erythropoiesis during Experimental Neuroses

Скурихин

Дыгай²,

Provalova³

et al. 2005

Bull Exp Biol Med

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We studied the mechanisms of erythropoiesis regulation in a conflict situation and during paradoxical sleep deprivation. Plastic reconstruction of the erythroid hemopoietic stem during experimental neuroses is regulated by a complex multicomponent and multilevel system. This system consists of central adrenergic structures, sympathetic part of the autonomic nervous system, and α-and β-adrenoceptors on erythroid precursors and cells of the hemopoietic microenvironment. Erythroid cells receive instructive information from the central nervous system via adrenoceptors on cells of the hemopoiesis-inducing microenvironment and erythroid precursors. Hyperplasia (conflict situation) and suppression of erythropoiesis (paradoxical sleep deprivation) are associated with specificity of central adrenergic regulatory mechanisms.

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confidence: 99%

Mechanisms of Regulation of Erythropoiesis during Experimental Neuroses

Скурихин

Дыгай²,

Provalova³

et al. 2005

Bull Exp Biol Med

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“…By contrast, GL were characterized by reticulocytopenia (day 1). The pool of erythroid precursors underwent different changes in mice subjected to PSD followed by maze training: in PL the number of CFU-E and ClFU-E in the bone marrow increased on (2,4) subjected to conflict situation (1, 2) or paradoxical sleep deprivation and training in a 3-arm T-maze (3,4). Ordinate: number of hemopoietic islets in the bone marrow, ×10 3 .…”

Section: Resultsmentioning

confidence: 99%

“…The blood system plays a role in adaptation to neuroses [3,4]. Proliferation and differentiation of hemopoietic cells during experimental neuroses are regulated by a complex multilevel system consisting of distant (neurotransmitters) and local mechanisms [1].…”

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confidence: 99%

“…Ratio of CFU-E (a, d) and ClFU-E in S-phase of the mitotic cycle (b, e) and maturation of erythroid cells in the bone marrow (c, f) of good (1, 3) and poor learned CBA/CaLac mice(2,4) subjected to conflict situation(1,2) or paradoxical sleep deprivation and training in a 3-arm T-maze(3,4). Ordinate: ratio of precursor cells (a, b, d, e) in S-phase of the mitotic cycle (%) and index of maturation (ratio between the numbers of clusters and colonies in a well, c, f).…”

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confidence: 99%

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Specific features of the erythroid hemopoietic stem in CBA/CaLac mice with neuroses demonstrating good and poor learning capacities

Першина¹,

Скурихин²,

Ставрова³

et al. 2004

Bull Exp Biol Med

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We studied changes in the erythroid hemopoietic stem in CBA/CaLac mice with experimental neuroses demonstrating good and poor learning capacities (conflict situation and paradoxical sleep deprivation followed by training in a 3-arm T-maze). The animals with different learning capacities exhibited pronounced hyperplasia of the erythroid hemopoietic stem in response to neurosis. Activation of the erythron in good learners was related to acceleration of division and maturation of erythroid precursors and enhanced formation of cell complexes containing central macrophage. In poor learners hyperplasia of the erythroid hemopoietic stem under conditions of conflict situation manifested in activation of proliferation and differentiation (against the background of decreased count of erythroid and mixed complexes in the bone marrow), while after paradoxical sleep deprivation followed by T-maze training this hyperplasia was associated with increased formation of additional hemopoietic islets (against the background of desynchronization of division and maturation of erythroid precursor cells).

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“…Adaptive response of the hemopoietic tissue depends on central neuroendocrine mechanisms [8,28,63,64], which realize their effects via universal stress-realizing (autonomic nervous system, pituitary-adrenal axis, opioid peptides) and stress-limiting systems (GABAergic system, opioid peptides, etc.) [18,27,67,761, the sympathoadrenat system being the main autonomic regulator of hemopoiesis [66].…”

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confidence: 99%