Responses of inferior colliculus neurons to sounds presented at different rates in anesthetized albino mouse

Бибиков, Н. Г.; Chen, Q.C.; Wu, Fei-Jian

doi:10.1016/j.heares.2008.04.008

Cited by 5 publications

(2 citation statements)

References 54 publications

(90 reference statements)

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“…In a subset of 22 neurons, however, the repetition rate was varied from 0.5 to 7 Hz. Similar to IC neurons recorded in previous studies (Willott and Demuth 1986; Chen and Jen 1994; Jen et al 2002; Bibikov et al 2008), neurons often decreased their firing rates as repetition rates increased. We therefore compared the proportional effects of mCPBG to the average spike count per stimulus (‘spike rate’; Fig 6, right column) in addition to the repetition rate itself (Fig 6, left column).…”

Section: Resultssupporting

confidence: 81%

“…In the neurons that exhibited it, this stimulus dependence usually resulted in a decreased selectivity for repetition rate, with neurons firing more equally across a range of repetition rates during activation of the 5-HT3 receptor. Because we only tested a limited range of stimulus rates comparable to those used in previous mouse studies (0.5 to 10 Hz, Willott and Demuth 1986; Bibikov et al 2008, it is unclear whether a larger range of repetition rates would reveal this type of effect in more neurons.…”

Section: Discussionmentioning

confidence: 99%

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Activation of serotonin 3 receptors changes in vivo auditory responses in the mouse inferior colliculus

Bohorquez

Hurley

2009

Hearing Research

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Metabotropic serotonin receptors such as 5-HT1A and 5-HT1B receptors shape the level, selectivity, and timing of auditory responses in the inferior colliculus (IC). Less is known about the effects of ionotropic 5-HT3 receptors, which are cation channels that depolarize neurons. In the current study, the influence of the 5-HT3 receptor on auditory responses in vivo was explored by locally iontophoresing a 5-HT3 receptor agonist and antagonists onto single neurons recorded extracellularly in mice. Three main findings emerge from these experiments. First, activation of the 5-HT3 receptor can either facilitate or suppress auditory responses, but response suppressions are not consistent with 5-HT3 effects on presynaptic GABAergic neurons. Both response facilitations and suppressions are less pronounced in neurons with high precision in response latency, suggesting functional differences in the role of receptor activation for different classes of neuron. Finally, the effects of 5-HT3 activation vary across repetition rate within a subset of single neurons, suggesting that the influence of receptor activation sometimes varies with the level of activity. These findings contribute to the view of the 5-HT3 receptor as an important component of the serotonergic infrastructure in the IC, with effects that are complex and neuron-selective.

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Section: Resultssupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Activation of serotonin 3 receptors changes in vivo auditory responses in the mouse inferior colliculus

Bohorquez

Hurley

2009

Hearing Research

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Local neuronal circuits that may shape the discharge patterns of inferior collicular neurons

Mei

Cheng

et al. 2013

Neurosci. Bull.

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The discharge patterns of neurons in auditory centers encode information about sounds. However, few studies have focused on the synaptic mechanisms underlying the shaping of discharge patterns using intracellular recording techniques. Here, we investigated the discharge patterns of inferior collicular (IC) neurons using intracellular recordings to further elucidate the mechanisms underlying the shaping of discharge patterns. Under in vivo intracellular recording conditions, recordings were obtained from 66 IC neurons in 18 healthy adult mice (Mus musculus, Km) under free fi eld-stimulation. Fiftyeight of these neurons fi red bursts of action potentials (APs) to auditory stimuli and the remaining eight just generated local responses such as excitatory (n = 4) or inhibitory (n = 4) postsynaptic potentials. Based on the APs and subthreshold responses, the discharge patterns were classifi ed into seven types: phasic (24/58, 41.4%), phasic burst (8/58,13.8%), pauser (4/58, 6.9%), phasic-pauser (1/58, 1.7%), chopper (2/58, 3.4%), primary-like tonic (14/58, 24.1%) and sound-induced inhibitory (5/58,8.6%). We concluded that (1) IC neurons exhibit at least seven distinct discharge patterns; (2) inhibition participates in shaping the discharge pattern of most IC neurons and plays a role in sculpting the pattern, except for the primary-like tonic pattern which was not shaped by inhibition; and (3) local neural circuits are the likely structural basis that shapes the discharge patterns of IC neurons and can be formed either in the IC or in lower-level auditory structures.

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Neuronal Network Plasticity and Network Interactions are Critically Dependent on Conditional Multireceptive (CMR) Brain Regions

Faingold

Riaz

Stittsworth

2014

Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics

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Responses of inferior colliculus neurons to sounds presented at different rates in anesthetized albino mouse

Cited by 5 publications

References 54 publications

Activation of serotonin 3 receptors changes in vivo auditory responses in the mouse inferior colliculus

Activation of serotonin 3 receptors changes in vivo auditory responses in the mouse inferior colliculus

Local neuronal circuits that may shape the discharge patterns of inferior collicular neurons

Neuronal Network Plasticity and Network Interactions are Critically Dependent on Conditional Multireceptive (CMR) Brain Regions

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