Responses of pigeon vestibular nerve fibers to sound and vibration with audiofrequencies

Wit, H. P.; Bleeker, J. D.; Mulder, H.

doi:10.1121/1.390396

Cited by 55 publications

(17 citation statements)

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“…Vibrations of different frequencies have been shown to excite saccular afferents in frogs [Christensen-Dalsgaard and Narins, 1993], lateral superior semicircular canal afferents in pigeons [Wit et al, 1984] and both superior semicircular canal and otolith afferents in squirrel monkeys [Young and Fernandez, 1977].…”

Section: Discussionmentioning

confidence: 99%

“…Lücke [1973] introduced this test in 1973 as a simple bedside method of detecting static anomalies of peripheral vestibular function. Vibration has been shown to excite the semicircular canals and otolithic afferents in animals [Young and Fernandez, 1977;Wit et al, 1984] and humans [Lackner, 1974;Dumas and Michel, 1997;Hamann and Schuster, 1999;Karlberg et al, 2003]. Three responses to a bone transmastoid vibratory stimulus are considered in humans: ocular, postural and perceptual [Suzuki et al, 1969].…”

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confidence: 99%

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Bone Vibration-Induced Nystagmus Is Useful in Diagnosing Superior Semicircular Canal Dehiscence

Manzari¹,

Modugno²,

Brandolini³

et al. 2008

Audiol Neurotol

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Objective: To explore vestibular integrity by bone vibration-induced nystagmus (VIN) during bedside examination. Disease or dysfunction of vestibular end organs would reduce or eliminate their contribution to total eye movement response to VIN. Background: It is assumed that vibration of the mastoid (at a frequency of 100 Hz) stimulates all vestibular end organs (semicircular canals and otolith structures). Previous studies have described oculomotor responses to vestibular activation by vibratory stimulus. Stimulation of individual semicircular canals produces eye movement in the plane of the stimulated canal. Vibratory stimulation of otolith structures (utricular macula) produces changes in ocular torsional position. Superior semicircular canal dehiscence (SCD) is responsible for nontypical cochleovestibular symptoms. Diagnosis is difficult without resorting to imaging, high-resolution computed tomography (HRCT) being the only tool providing reliable assessment. To avoid unnecessary referral for expensive imaging, it would be useful to have a simple screening test to select cases for HRCT. Methods: Video eye movements were recorded in complete darkness in patients diagnosed with SCD. The eye movement responses to long-lasting unilateral vibratory stimulation applied to the mastoid surface were evaluated. Results: VIN evoked a response in all cases, mostly demonstrating excitation of the affected side. The pattern of vertical, torsional and horizontal eye velocity and eye position was evaluated with three-dimensional infrared video-oculography (50 Hz sampling). Conclusion: Analysis of VIN, recently proposed to study transmission of excitatory stimuli by bone conduction, may be appropriate for altered immittance caused by dehiscence. This promises to be an interesting new field of research.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Bone Vibration-Induced Nystagmus Is Useful in Diagnosing Superior Semicircular Canal Dehiscence

Manzari¹,

Modugno²,

Brandolini³

et al. 2008

Audiol Neurotol

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“…The drilling of the temporal bone is of more concern, because fenestration of the labyrinth can produce dramatically lowered acoustic thresholds in the vestibular afferents of many animals (Tullio, 1938;Mikaelian, 1964;Wit et al, 1984;Ribaric et al, 1992). For this reason, we meticulously maintained the integrity of the bony labyrinth.…”

Section: Saccular Acoustic Responses In the Catmentioning

confidence: 99%

Acoustically responsive fibers in the vestibular nerve of the cat

1994

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Recordings were made from single afferent fibers in the inferior vestibular nerve, which innervates the saccule and posterior semicircular canal. A substantial portion of the fibers with irregular background activity increased their firing in response to moderately intense clicks and tones. In responsive fibers, acoustic clicks evoked action potentials with minimum latencies of < or = 1.0 msec. Fibers fell into two classes, with the shortest latency either to condensation clicks (PUSH fibers) or to rarefaction clicks (PULL fibers). Low- frequency (800 Hz) tone bursts at moderately high sound levels (> 80 dB SPL) caused synchronization of spikes to preferred phases of the tone cycle. PUSH and PULL fibers had preferred response phases approximately 180 degrees apart. These two response classes are consistent with fibers that innervate hair cells having opposite morphological polarizations, an arrangement found in the saccule. With low-frequency tone bursts, sound levels of > or = 90 dB SPL evoked increases in mean spike rate. Spike rates increased monotonically with sound level without saturating at levels < or = 115 dB SPL. Contraction of the middle-ear muscles decreased responses to sound, consistent with the sound transmission path being through the middle ear. Several fibers were labeled with biocytin and traced. All labeled fibers had bipolar cell bodies in the inferior vestibular ganglion with peripheral processes extending toward the saccular nerve and central processes in the vestibular nerve. Two fibers were traced to the saccular epithelium. One fiber was traced centrally and arborized extensively in vestibular nuclei and a region ventromedial to the cochlear nucleus. Our results confirm and extend previous suggestions that the mammalian saccule responds to sound at frequencies and levels within the normal range of human hearing. We suggest a number of auditory roles that these fibers may play in the everyday life of mammals.

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“…Other authors have demonstrated a response of vestibular afferents to audiofrequency stimuli: Wit et al [20] in pigeons, Murofushi and Curthoys [21] in guinea pigs, and McCue and Guinan [22] in cats. Colebatch and Halmagyi [23] demonstrated EMG activity in the sternomastoid muscle in response to click stimuli.…”

Section: Response Of the Vestibular System To High Frequency Stimulationmentioning

confidence: 99%

The Contribution of High-Frequency Stimulation in Vestibular Testing

Elidan¹,

Rodionov²

2001

Otorhinolaryngol Nova

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Recently it was shown that abrupt head acceleration impulses induce short latency response in the neuronal pathways of the vestibular system and a short latency vestibulooculomotor response. This phenomenon cannot be explained only with the frame of the classical torsion pendulum model of the cupuloendolymphatic system and passive reaction of the vestibular receptors to the cupular displacement. All three stages of stimulus transduction: mechanical, receptive and neuronal, are revisited in recent studies, and these findings are analyzed in the present paper. The head impulse test of Halmagyi and his colleagues, the high frequency head oscillations using special helmet [Tabak et al., 1995, 1997a, b], the autorotation test [O’Leary, 1990; Hirvonen 1998], the technique of recording vestibular evoked potentials to acceleration impulses [Elidan at al.] are discussed. In spite of some deficits in our knowledge, the exclusive diagnostic value of the high-frequency and high-intensity (impulse) stimuli became already obvious. It is concluded that the proper differentiation between the mechanical, receptor and afferent neuronal parts of the vestibular end organ may be achieved only by applying stimuli with different frequency content. Further investigations are requested to elucidate the specific mechanisms of vestibular sensitivity to the different stimuli used for this purpose, and the possible directions of these studies are discussed.

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Responses of pigeon vestibular nerve fibers to sound and vibration with audiofrequencies

Cited by 55 publications

References 0 publications

Bone Vibration-Induced Nystagmus Is Useful in Diagnosing Superior Semicircular Canal Dehiscence

Bone Vibration-Induced Nystagmus Is Useful in Diagnosing Superior Semicircular Canal Dehiscence

Acoustically responsive fibers in the vestibular nerve of the cat

The Contribution of High-Frequency Stimulation in Vestibular Testing

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