On‐farm seed priming has been reported to improve emergence, crop establishment, and yield besides improving economic benefits in dryland agriculture. These benefits can further be improved by fertilizer micro‐dosing. The purpose of this study was to investigate the effect of on‐farm seed priming and fertilizer micro‐dosing on the agronomic and economic returns of maize (Zea mays L. var. Melkassa‐2) in semi‐arid agro‐ecological conditions in Ethiopia. The experiments consisted of four treatments: no priming and no fertilizer; no priming and fertilizer; priming and no fertilizer; and priming and fertilizer. The experiments were conducted in three locations viz., Melkassa, Ziway, and Hawassa in the central Rift Valley. Analysis of variance for each location was performed separately at p ˂ .05. Results of each location were similar over the experimentation years, and hence, there was no need for carrying out combined analysis. Regardless of fertilization, primed plants showed faster emergence; better uniform crop stands; more vigorous plants; earlier flowering; earlier harvest; and higher grain and stover yield than no primed plants. Germination was 2–3 days earlier, and flowering and maturation of primed plants were 10 to 13 days earlier than no primed plants. Average grain yield increased by 11, 8, and 6% in Melkassa, Ziway, and Hawassa, respectively, by priming over no priming. Fertilizer micro‐dosing combined with priming further improved most of the agronomic characters. Fertilizer micro‐dosing combined with priming increased the average grain yield by 75, 69, and 33% in Melkassa, Ziway, and Hawassa, respectively. The economic returns also increased in the same pattern as the agronomic responses for priming, micro‐dosing or their combination. To realize the potential of seed priming of increasing agronomic performances, future research and development efforts should focus on understanding the possible underling physiological and biochemical basis of this poorly understood process with the different priming techniques.