Responses of the central nervous system to acute hypoxic-ischemic injury and related conditions

Itabashi, Hideo H.; Andrews, John M.; Tomiyasu, Uwamie; Erlich, Stephanie S.; Sathyavagiswaran, Lakshmanan

doi:10.1016/b978-012058527-4/50012-2

Cited by 1 publication

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“…Within 1 h of the insult microvacuolization with normal or shrunken nucleus, cell shrinkage, normal or slightly basophilic cytoplasm, and perineuronal spaces around some neurons may be observed. These changes cannot be distinguished from postmortem autolysis [ 27 ]. For this reason we proposed BYSL as a new marker of early ongoing neuronal changes after hypoxic-ischemic episodes.…”

Section: Discussionmentioning

confidence: 99%

“…Typical neuropathological hypoxic-ischemic changes include: ischemic cell change - seen in the first 6 h of survival, with further neuronal nucleus and cytoplasm shrinkage and pink cytoplasm staining; homogenizing cell change typically seen around 24 h after survival; and a final stage termed “ghost cell” with reduced or absent cytoplasm around a dark and shrunken nucleus and eventual cell loss [ 27 ]. In our HI group ischemic neurons were present despite the fact that death occurred immediately after the ischemic episode.…”

Section: Discussionmentioning

confidence: 99%

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Bystin (BYSL) as a possible marker of severe hypoxic-ischemic changes in neuropathological examination of forensic cases

Olczak

Chutorański

Kwiatkowska

et al. 2018

Forensic Sci Med Pathol

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Bystin (BYSL) is a 306-amino acid protein encoded in humans by the BYSL gene located on the 6p21.1 chromosome. It is conserved across a wide range of eukaryotes. BYSL was reported to be a sensitive marker for the reactive astrocytes induced by ischemia/reperfusion and chemical hypoxia in vitro and is considered to be one of the common characteristics of astrogliosis. In our study we examined whether BYSL could be used as a marker for hypoxic-ischemic changes in forensic cases. Groups suspected of acute hypoxic-ischemic changes presented strong BYSL expression in the cytoplasm of neocortical neurons especially in layers 3–5, that seemed to be short-lasting. In the hypoxic-ischemic-reperfusion group we did not find BYSL expression. BYSL expression in the cytoplasm of cortical neurons was minimal in the control group (cardiac arrest). BYSL seems to be a promising early marker of severe hypoxic-ischemic changes in neuropathological examination of forensic cases and certainly requires further studies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%