2017
DOI: 10.3389/fmicb.2017.00583
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Responses of the Housefly, Musca domestica, to the Hytrosavirus Replication: Impacts on Host's Vitellogenesis and Immunity

Abstract: Hytrosaviridae family members replicate in the salivary glands (SGs) of their adult dipteran hosts and are transmitted to uninfected hosts via saliva during feeding. Despite inducing similar gross symptoms (SG hypertrophy; SGH), hytrosaviruses (SGHVs) have distinct pathobiologies, including sex-ratio distortions in tsetse flies and refusal of infected housefly females to copulate. Via unknown mechanism(s), SGHV replication in other tissues results in reduced fecundity in tsetse flies and total shutdown of vite… Show more

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Cited by 19 publications
(18 citation statements)
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“…The down-regulation of these genes may explain the ovarian abnormalities and reduced reproductive fitness observed in symptomatically infected female tsetse flies. Similar observations have been reported in the housefly, Musca domestica , whereby MdSGHV infections which causes similar SGH syndrome in their host, were found to suppress vitellogenesis by blocking the transcription of hexamerin and yolk proteins and cause shut down of oogenesis and hence reduce reproduction ( Kariithi et al, 2017 ).…”
Section: Discussionsupporting
confidence: 82%
“…The down-regulation of these genes may explain the ovarian abnormalities and reduced reproductive fitness observed in symptomatically infected female tsetse flies. Similar observations have been reported in the housefly, Musca domestica , whereby MdSGHV infections which causes similar SGH syndrome in their host, were found to suppress vitellogenesis by blocking the transcription of hexamerin and yolk proteins and cause shut down of oogenesis and hence reduce reproduction ( Kariithi et al, 2017 ).…”
Section: Discussionsupporting
confidence: 82%
“…The sole member of the genus Muscavirus , the M. domestica SGHV (MdSGHV), infects and causes only symptomatic SGH in houseflies [ 14 , 15 ]. Topical exposure or injection of MdSGHV into adult houseflies results in overt SGH and total shutdown of oogenesis, thus inhibiting any potential for the vertical transmission of this virus [ 15 , 16 ]. MdSGHV is globally distributed within populations of the synanthropic housefly [ 17 ], a highly mobile insect that moves several kilometers in search of feeding and oviposition sites associated with livestock keeping [ 18 ].…”
Section: Introductionmentioning
confidence: 99%
“…The diverticulated crop of dipterans can no longer be considered just a storage organ for nutrients, but is an important chamber, isolated from midgut fluids and the hemolymph, where pathogens and beneficial microbes, plus AMPs or other secretions from the labellar and salivary glands interact. Finally, even though the ultimate fly model has become D. melanogaster, studies involving genetics and molecular techniques, similar to those reported by Chtarbanova et al (2014), where a virus affects crop function should be applied to the hytrosavirus systems found in tsetse fly (Kariithi et al, 2017b), the house fly (Kariithi et al, 2017a), and other insect systems involving microbial associations. Both tsetse, mosquitoes and house flies are significantly more important than Drosophila when it comes to human welfare.…”
Section: Discussionmentioning
confidence: 99%