Responses to rumen-protected choline in transition cows do not depend on prepartum body condition

Bollatti, J.M.; Zenobi, M.G.; Barton, B.A.; Staples, C.R.; Santos, J.E.P.

doi:10.3168/jds.2019-17302

Cited by 15 publications

(13 citation statements)

References 44 publications

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“…Most cows in our data set (83%) had the greatest liver TG content at 14 DIM. This is in agreement with previous literature that indicated liver TG content typically peaks between 1 and 3 weeks postpartum [ 1 , 53 ].…”

Section: Resultssupporting

confidence: 93%

“…These comparisons suggest that assessment of maximum liver TG content during early lactation is possible by analysis of a single blood sample at a key DIM timepoint. The 7 and 14 DIM timepoints appeared to perform similar to multiple timepoint models, which corresponds to the approximate DIM window that maximum liver TG accumulation typically occurs [ 1 , 53 ].…”

Section: Resultsmentioning

confidence: 99%

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Prediction of Liver Triglyceride Content in Early Lactation Multiparous Holstein Cows Using Blood Metabolite, Mineral, and Protein Biomarker Concentrations

Pralle

Holdorf

Oliveira

et al. 2022

Animals

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Bovine fatty liver syndrome (bFLS) is difficult to diagnose because a liver tissue biopsy is required to assess liver triglyceride (TG) content. We hypothesized that a blood biomarker panel could be a convenient alternative method of liver TG content assessment and bFLS diagnosis. Our objectives were to predict liver TG using blood biomarker concentrations across days in milk (DIM; longitudinal, LT) or at a single timepoint (ST; 3, 7, or 14 DIM), as well as different biomarker combination based on their perceived accessibility. Data from two separate experiments (n = 65 cows) was used for model training and validation. Response variables were based on the maximum liver TG observed in 1 and 14 DIM liver biopsies: Max TG (continuous), Low TG (TG > 13.3% dry matter; DM), Median TG (TG > 17.1% DM), and High TG (TG > 22.0% DM). Model performance varied but High TG was well predicted by sparse partial least squares—discriminate analysis models using LT and ST data, achieving balanced error rates ≤ 15.4% for several model variations during cross-validation. In conclusion, blood biomarker panels using 7 DIM, 14 DIM, or LT data may be a useful diagnostic tool for bFLS in research and field settings.

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Section: Resultssupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Prediction of Liver Triglyceride Content in Early Lactation Multiparous Holstein Cows Using Blood Metabolite, Mineral, and Protein Biomarker Concentrations

Pralle

Holdorf

Oliveira

et al. 2022

Animals

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“…Additionally, rumen-protected choline supplementation has been found to reduce the concentration of liver triacylglycerol and metabolic stress, resulting in an improved immune and antioxidative state ( 79 , 80 ). Consistent with this, choline supplementation also lowers BHBH levels and the body condition score, which is the best indicator of health in dairy cattle during the periparturient period ( 81 , 82 ). Furthermore, it has been reported that excessive production of NEFA and BHB may compromise immunity, resulting in abnormal regulation of immune and inflammation responses ( 83 ).…”

Section: Effect Of Rumen-protected First-limiting Amino Acids (Methio...supporting

confidence: 61%

Overview of the effect of rumen-protected limiting amino acids (methionine and lysine) and choline on the immunity, antioxidative, and inflammatory status of periparturient ruminants

Khan

Liu

et al. 2023

Front. Immunol.

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Overproduction of reactive oxygen species (ROS) is a well-known phenomenon experienced by ruminants, especially during the transition from late gestation to successful lactation. This overproduction of ROS may lead to oxidative stress (OS), which compromises the immune and anti-inflammatory systems of animals, thus predisposing them to health issues. Besides, during the periparturient period, metabolic stress is developed due to a negative energy balance, which is followed by excessive fat mobilization and poor production performance. Excessive lipolysis causes immune suppression, abnormal regulation of inflammation, and enhanced oxidative stress. Indeed, OS plays a key role in regulating the metabolic activity of various organs and the productivity of farm animals. For example, rapid fetal growth and the production of large amounts of colostrum and milk, as well as an increase in both maternal and fetal metabolism, result in increased ROS production and an increased need for micronutrients, including antioxidants, during the last trimester of pregnancy and at the start of lactation. Oxidative stress is generally neutralized by the natural antioxidant system in the body. However, in some special phases, such as the periparturient period, the animal’s natural antioxidant system is unable to cope with the situation. The effect of rumen-protected limiting amino acids and choline on the regulation of immunity, antioxidative, and anti-inflammatory status and milk production performance, has been widely studied in ruminants. Thus, in the current review, we gathered and interpreted the data on this topic, especially during the perinatal and lactational stages.

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“…However, there were no effects on production when RPC was supplied during the post-transition period [174]. Lastly, it is important to note that Bollatti et al [175] reported that improvements in milk, fat and protein yields, as well as increases in energy-and fat-corrected milk with RPC supply during the peripartal period were not dependent on prepartum BCS. Overall, the above studies suggest that enhanced choline supply will be most-beneficial during the peripartal period, and that it may be particularly beneficial for primiparous cows.…”

Section: Practical Nutritional Recommendations For Balancing Dietary Methyl Donorsmentioning

confidence: 89%

Multifaceted role of one-carbon metabolism on immunometabolic control and growth during pregnancy, lactation and the neonatal period in dairy cattle

Coleman

Alharthi

Liang

et al. 2021

J Animal Sci Biotechnol

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Dairy cattle undergo dramatic metabolic, endocrine, physiologic and immune changes during the peripartal period largely due to combined increases in energy requirements for fetal growth and development, milk production, and decreased dry matter intake. The negative nutrient balance that develops results in body fat mobilization, subsequently leading to triacylglycerol (TAG) accumulation in the liver along with reductions in liver function, immune dysfunction and a state of inflammation and oxidative stress. Mobilization of muscle and gluconeogenesis are also enhanced, while intake of vitamins and minerals is decreased, contributing to metabolic and immune dysfunction and oxidative stress. Enhancing post-ruminal supply of methyl donors is one approach that may improve immunometabolism and production synergistically in peripartal cows. At the cellular level, methyl donors (e.g. methionine, choline, betaine and folic acid) interact through one-carbon metabolism to modulate metabolism, immune responses and epigenetic events. By modulating those pathways, methyl donors may help increase the export of very low-density lipoproteins to reduce liver TAG and contribute to antioxidant synthesis to alleviate oxidative stress. Thus, altering one-carbon metabolism through methyl donor supplementation is a viable option to modulate immunometabolism during the peripartal period. This review explores available data on the regulation of one-carbon metabolism pathways in dairy cows in the context of enzyme regulation, cellular sensors and signaling mechanisms that might respond to increased dietary supply of specific methyl donors. Effects of methyl donors beyond the one-carbon metabolism pathways, including production performance, immune cell function, mechanistic target or rapamycin signaling, and fatty acid oxidation will also be highlighted. Furthermore, the effects of body condition and feeding system (total mixed ration vs. pasture) on one-carbon metabolism pathways are explored. Potential effects of methyl donor supply during the pepartum period on dairy calf growth and development also are discussed. Lastly, practical nutritional recommendations related to methyl donor metabolism during the peripartal period are presented. Nutritional management during the peripartal period is a fertile area of research, hence, underscoring the importance for developing a systems understanding of the potential immunometabolic role that dietary methyl donors play during this period to promote health and performance.

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Responses to rumen-protected choline in transition cows do not depend on prepartum body condition

Cited by 15 publications

References 44 publications

Prediction of Liver Triglyceride Content in Early Lactation Multiparous Holstein Cows Using Blood Metabolite, Mineral, and Protein Biomarker Concentrations

Prediction of Liver Triglyceride Content in Early Lactation Multiparous Holstein Cows Using Blood Metabolite, Mineral, and Protein Biomarker Concentrations

Overview of the effect of rumen-protected limiting amino acids (methionine and lysine) and choline on the immunity, antioxidative, and inflammatory status of periparturient ruminants

Multifaceted role of one-carbon metabolism on immunometabolic control and growth during pregnancy, lactation and the neonatal period in dairy cattle

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