Respuesta a fluoxetina y polimorfismos del transportador de serotonina en trastorno límite de personalidad

Abstract

Introduction: Impulsiveness and aggressiveness are characteristics of borderline personality disorders. Aggressive and impulsive behaviors are associated to a serotoninergic system dysfunction and are treated with selective serotonin reuptake inhibitors (SSRIs). The short (S) allele of the serotonin transporter promoter (5-HTTPR) gene is associated to a worse response to SSRI in major depression. The objective of this work is to study the anti-impulsive effect of fluoxetine and his relation with short and long alleles of 5-HTTPR gene in borderline personality disordered patients. Method: 59 patients with DSM-IV borderline personality disorder were treated with fluoxetine for 12 weeks. Impulsivity was evaluated with the Overt Aggression Scale Modified (OAS-M). Polymorphisms L and S of the 5-HTTPR gene were determined. Results: S carriers (LS and SS) had a significantly minor response on OAS-M and

Polimorfismo corto del gen del transportador de la serotonina (5-httplr) y su asociación con la respuesta al estrés mediada por cortisol: un meta-análisis.

“…Among these neurotransmitters in charge of activating the Hypothalamic-Pituitary-Adrenal axis, there is the serotonin transporter which has certainly been the most studied neurotransmitter. Its gen (SLC6A4) has two alleles; the short allele is related to a lower transcriptional activity and a reduction of the efficiency in the reuptake of serotonin, whereas the long allele carriers (L) have a better or quicker response to the reuptake of serotonin (Silva et al, 2010). Recently, it has been observed that the gen of serotonin transporter is a locus with three alleles named La, Lg and S, where Lg and S alleles could be compared regarding their low expressions levels as compared with La (Hu et al, 2006;Kraft, Slager, McGrath & Hamilton, 2005).…”