Rest-Redistribution 201Tl Single-Photon Emission CT Imaging for Determination of Myocardial Viability

Time-dependent bias was common in survival analyses published in leading clinical journals

“…In three studies (7.9% [2.7-20.8%]), correction of time-dependent bias could have made the permissive hazard ratio or relative risk statistically significant [47,48,86]. In 20 studies where the relative risk was less than 1 (52.6% [37.3-67.5%]), correction of timedependent bias could have nullified previously significant hazard ratios or relative risks or could have transformed the preventive relative risk into a permissive hazard ratio or relative risk [45,50,52,53,55,57,[61][62][63]65,71,77,78,81,83,[87][88][89][90][91].…”

Quantity of viable myocardium required to improve survival with revascularization in patients with ischemic cardiomyopathy: A meta-analysis

“…[27][28][29][30][31][32][33][34][35][36][37] The uptake of these flow tracers in SPECT imaging can show the preservation of resting myocardial perfusion in dysfunctional myocardium, and therefore, the presence of viability. Compared to FDG-PET studies which identify the specific area (perfusion-metabolism mismatch) in myocardium with preserved perfusion, a higher amount of viable myocardium may be needed to lead to improved survival with revascularization ( Figure 5).…”

Myocardial perfusion scintigraphy: the evidence

“…In patients with ischaemic left ventricular dysfunction, MPS can define the need for revascularisation by determining the presence and extent of ischaemia and of viable but hibernating myocardium [ 193 , 194 , 195 , 196 ] (Table 9 ). This is particularly the case with severe left ventricular dysfunction, when MPS can predict the improvement in left ventricular function and the overall prognosis [ 181 , 197 , 198 ]. MPS is most helpful when left ventricular ejection fraction is severely reduced, and in these high-risk patients rest imaging alone can detect viable myocardium [ 199 , 200 , 201 , 202 , 203 , 204 ].…”