Restenosis Treatments Using Nanoparticle-based Drug Delivery Systems

Gu, Zi; Rolfe, Barbara E.; Thomas, Anita C.; Xu, Zhi Ping

doi:10.2174/1381612811319350009

Cited by 19 publications

(11 citation statements)

References 96 publications

(124 reference statements)

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“…118 In the case of LDH nanocarriers, recent progress in targeting moiety design has been seen in conjugating folic acid and antibody agents. 20,57,[119][120][121] Folic acid has a high affinity (K d E 100 pM) for folate receptors which are often overexpressed in various human cancers, such as ovary, lung, kidney, colon cancer, etc.…”

Section: Ldh@targeting Moietymentioning

confidence: 99%

Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications

2015

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a Layered double hydroxide (LDH)-based nanocomposites, constructed by interacting LDH nanoparticles with other nanomaterials (e.g. silica nanoparticles and magnetic nanoparticles) or polymeric molecules (e.g. proteins), are an emerging yet active area in healthcare, environmental remediation, energy conversion and storage.Combining advantages of each component in the structure and functions, hierarchical LDH-based nanocomposites have shown great potential in biomedicine, water purification, and energy storage and conversion.This feature article summarises the recent advances in LDH-based nanocomposites, focusing on their synthesis, structure, and application in drug delivery, bio-imaging, water purification, supercapacitors, and catalysis.

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Section: Ldh@targeting Moietymentioning

confidence: 99%

Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications

2015

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“…It has been reported that TiO 2 and modified TiO 2 NPs had great potential as drug delivery and molecular imaging vehicles in the CV system . Restenosis, the re‐narrowing of a blood vessel after the removal of an atherosclerotic plaque, is a major limitation of the surgical treatments for atherosclerosis, which may be prevented or treated by inorganic nanoparticles, such as TiO2 NPs, to deliver drugs …”

Section: Medical Applicationsmentioning

confidence: 99%

Bio‐effect of nanoparticles in the cardiovascular system

Hong

Zhang

2016

J Biomedical Materials Res

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Nanoparticles (NPs; < 100 nm) are increasingly being applied in various fields due to their unique physicochemical properties. The increase in human exposure to NPs has raised concerns regarding their health and safety profiles. The potential correlation between NP exposure and several cardiovascular (CV) events has been demonstrated. The aim of this review is to provide a comprehensive evaluation of the current knowledge regarding the bio-toxic impacts of titanium oxide, silver, silica, carbon black, carbon nanotube, and zinc oxide NPs exposure on the CV system in terms of in vivo and in vitro experiments, which is not fully understood presently. Moreover, the potential toxic mechanisms of NPs in the CV system that are still being questioned are elaborately discussed, and the underlying capacity of NPs used in medicine for CV events are summarized. It will be an important instrument to extrapolate relevant data for human CV risk evaluation and management. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2881-2897, 2016.

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“…Recently medical applications of TiO 2 NP for drug delivery have also been envisaged 75 (Carlander, 2016), e.g., for restenosis treatment (Gu, 2013), making use of their physical 76 properties for light-controlled drug release (Wang, 2015) or ultrasound cancer treatment 77 (Ninomiya, 2014). On the other hand the release and fate of nanosized fractions of wear 78 corrosion debris from orthopedic and dental titanium implants has become a concern 79 (Matusiewicz, 2014).…”

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confidence: 99%

Quantitative biokinetics of titanium dioxide nanoparticles after intravenous injection in rats: Part 1

et al. 2017

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Submicrometer TiO particles, including nanoparticulate fractions, are used in an increasing variety of consumer products, as food additives and also drug delivery applications are envisaged. Beyond exposure of occupational groups, this entails an exposure risk to the public. However, nanoparticle translocation from the organ of intake and potential accumulation in secondary organs are poorly understood and in many investigations excessive doses are applied. The present study investigates the biokinetics and clearance of a low single dose (typically 40-400 μg/kg BW) of V-radiolabeled, pure TiO anatase nanoparticles ([V]TiONP) with a median aggregate/agglomerate size of 70 nm in aqueous suspension after intravenous (IV) injection into female Wistar rats. Biokinetics and clearance were followed from one-hour to 4-weeks. The use of radiolabeled nanoparticles allowed a quantitative [V]TiONP balancing of all organs, tissues, carcass and excretions of each rat without having to account for chemical background levels possibly caused by dietary or environmental titanium exposure. Highest [V]TiONP accumulations were found in liver (95.5%ID after one day), followed by spleen (2.5%), carcass (1%), skeleton (0.7%) and blood (0.4%). Detectable nanoparticle levels were found in all other organs. The [V]TiONP content in blood decreased rapidly after 24 h while the distribution in other organs and tissues remained rather constant until day-28. The present biokinetics study is part 1 of a series of studies comparing biokinetics after three classical routes of intake (IV injection (part 1), ingestion (part 2), intratracheal instillation (part 3)) under identical laboratory conditions, in order to test the common hypothesis that IV-injection is a suitable predictor for the biokinetics fate of nanoparticles administered by different routes. This hypothesis is disproved by this series of studies.

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Restenosis Treatments Using Nanoparticle-based Drug Delivery Systems

Cited by 19 publications

References 96 publications

Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications

Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications

Bio‐effect of nanoparticles in the cardiovascular system

Quantitative biokinetics of titanium dioxide nanoparticles after intravenous injection in rats: Part 1

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