Resting and Action Potentials in Red and White Muscles of the Rat

Yonemura, K

doi:10.2170/jjphysiol.17.708

Cited by 56 publications

(27 citation statements)

References 10 publications

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“…mV (750 fibres from 20 muscles) and that of the soleus, 69-4 + 0-1 mV at 330 C. These values are in good agreement with those reported for rat muscles, i.e. 79 mV for EDL and 68 mV for the soleus (Yonemura, 1967 potential was not much affected by isoprenaline (1 ,ug/ml), whereas in the soleus it was clearly increased (Table 2). In the rat diaphragm, adrenaline has no significant effect on the resting membrane potential (Krnjevic & Miledi, 1958).…”

Section: Methodssupporting

confidence: 90%

Effects of isoprenaline on contractions of directly stimulated fast and slow skeletal muscles of the guinea‐pig

Tashiro

1973

British J Pharmacology

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Summary1. The actions of isoprenaline on the contraction and the resting potential of the isolated extensor digitorum longus (EDL), a fast contracting muscle, and the soleus, a slow contracting muscle, of the guinea-pig were investigated. Twitch tension was elicited by direct supramaximal stimulation and recorded isometrically.2. The twitch tension of EDL elicited by pulses of 0 5-10 ms duration was increased in the presence of isoprenaline (1 ug/ml). Isoprenaline increased the twitch tension of the soleus elicited by a pulse of more than 5 ms duration, but decreased it when elicited by a pulse of less than 1 millisecond. These effects were blocked by propranolol (1-3 ,ug/ml) but not by phentolamine (1-5 gg/ml).3. In EDL, isoprenaline prolonged the time to peak tension and the halfrelaxation time. The twitch of the soleus was shortened by isoprenaline due to an acceleration of relaxation. These findings were independent of stimulus duration. 4. The potentiating effects of isoprenaline on the twitch tension of EDL and the soleus were not observed in K+-free Krebs solution and were abolished by ouabain (1 gg/ml) and by reduction of the temperature from 330 to 180 C.The effects of isoprenaline on the relaxation process were not affected by these treatments. 5. In EDL, the resting potential increased from 77-3 mV to 78-5 mV after isoprenaline, whereas in the soleus it increased from 69 1 to 74-7 mV. These effects were blocked by propranolol, K+-deficiency, ouabain, and cooling to 18°C. Hyperpolarization by isoprenaline was increased by substitution of isethionate for the external chloride. 6. There was a good correlation between the potentiation of the mechanical response and the hyperpolarization of the membrane by isoprenaline. The hyperpolarization seems to be due to activation of the Na+-K+ pump.

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Section: Methodssupporting

confidence: 90%

Effects of isoprenaline on contractions of directly stimulated fast and slow skeletal muscles of the guinea‐pig

Tashiro

1973

British J Pharmacology

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“…The percent of total water that was extracellular, as calculated Peter [20] for discussion). The guinea pig white vastus studied here is a fast-twitch muscle like the rat extensor digitorum longus, and the measured RMP of -85.3 mV found in this study is similar to the RMP of -78.2 and -85 mV found in the rat extensor digitorum longus by Yonemura (17) and Federov (18). The RMP measured here in guinea pig soleus of -69.7 mV also approximates the -66 mV Yonemura found in rat soleus.…”

Section: Log'k+)ecf + 001 (N~a+)ecf'supporting

confidence: 88%

Resting Membrane Potential and Ionic Distribution in Fast- and Slow-Twitch Mammalian Muscle

Campion¹

1974

J. Clin. Invest.

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A B S T R A C T The resting membrane potential and intracellular potassium and sodium concentration of three guinea pig hind limb muscles were studied. These properties are related to the gross color, the speed of contraction, and the biochemically defined fiber type composing the muscle. The resting membrane potential and intracellular content were: white vastus (grossly white, fasttwitch glycolytic) -85.3 mV, potassium 171.9 meq/ liter; soleus (grossly red, slow-twitch oxidative) -69.7 mV, potassium 137.5 meq/liter; and red vastus lateralis (grossly red, fast-twitch oxidative glycolytic) -71.7 mV, potassium 139.6 meq/liter. In soleus and red vastus lateralis, the relative permeability of sodium to potassium was 0.041 and 0.036, while in white vastus it was 0.015. These results give us the first exception to the hypothesis that fast-twitch fibers have higher intracellular potassium and higher resting membrane potential than slow-twitch fibers.

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“…In the ipsilateral leg the tibialis anterior was chosen; it was found to have higher fibre resting membrane potentials (mean -87-8 + 7 6 mV, n = 80) than soleus, in keeping with other observations of differences between fast-twitch and slow-twitch muscles (cf. Yonemura, 1967), but there was no sign of an HR after repetitive excitation of soleus (mean resting potential -86-4 + 7 0 mV, n = 159).…”

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confidence: 91%

Transient hyperpolarization of non‐contracting muscle fibres in anaesthetized rats.

Kuiack

McComas

1992

The Journal of Physiology

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SUMMARY1. Following laminectomy, the L5 ventral roots of anaesthetized rats were split and approximately half of the nerve fibres were stimulated at 40 Hz. Resting membrane potentials were then measured in previously contracting and noncontracting soleus muscle fibres.2. In the non-contracting soleus fibres there was a post-tetanic increase in mean resting potential (from -822+ 7-1 (S.D.) to -91-6+ 87 mV) which was similar to that in contracting fibres (from -83-02 + 6-1 to -913 + 7.3 mV). In both types of fibres the hyperpolarizing responses (HRs) were evidently due to increased sodium pump activity since they could be abolished by the addition of ouabain (1 x 10-4 M) to the bathing fluid.3. The fl-adrenergic antagonist, propranolol, completely suppressed HRs in the non-contracting fibres and produced moderate reductions in the contracting ones. The a-adrenergic blocking agent, phentolamine, had no effect on the contracting fibres and only a modest, inhibitory, one on the non-contracting fibres.4. On the basis of the above drug actions it appeared that catecholamines were necessary for the full development of HRs in contracting and non-contracting fibres; noradrenaline, released from intramuscular sympathetic nerve endings, may have been involved.5. The increased sodium pump activity in the non-contracting fibres would serve to moderate the rise in interstitial [K+] caused by K+ efflux from the contracting fibres. By preventing passive depolarization, due to the rise in interstitial [K+], the sodium pump would also maintain the availability of non-contracting fibres for subsequent recruitment.

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Resting and Action Potentials in Red and White Muscles of the Rat

Cited by 56 publications

References 10 publications

Effects of isoprenaline on contractions of directly stimulated fast and slow skeletal muscles of the guinea‐pig

Effects of isoprenaline on contractions of directly stimulated fast and slow skeletal muscles of the guinea‐pig

Resting Membrane Potential and Ionic Distribution in Fast- and Slow-Twitch Mammalian Muscle

Transient hyperpolarization of non‐contracting muscle fibres in anaesthetized rats.

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