Resting Magnetocardiography Predicts 3‐Year Mortality in Patients Presenting with Acute Chest Pain without ST Segment Elevation

Abstract

Resting MCG at hospital admission predicts 3-year mortality in patients presenting with acute chest pain without ST segment elevation in the ECG. MCG seems to be valuable in identifying chest pain patients at highest risk.

Special article Magnetocardiography in clinical cardiology. Status quo and future applications

“…Tolstrup et al published comparable results using the same device and software [31]. Interestingly, a multivariate regression analysis after a 3-year follow-up revealed the highest mortality risk for patients with diabetes mellitus and an abnormal MCG at admission (RR = 18.0; 95% CI: 2.49-133.3) [32]. By the use of a shielded 55-sensor multichannel MCG system (ATB, Italy), allowing the recording of the heart's entire magnetic field every 2 ms, a further clinical study showed that MCG can be performed together with a standard dobutamine/ atropine stress protocol [33].…”

Early detection of coronary artery disease in patients studied with magnetocardiography: An automatic classification system based on signal entropy

“…Other MCG based methods were developed to differentiate CAD patients using the current distribution parameters during repolarization (sensitivity of 85.7% and specificity of 74.3%) [18] or the subtracted ST-T waveform (sensitivity of 74.6% and specificity of 84.1%) [19]. The greater power of MCG as compared to ECG in discriminating ventricular dispersion in cardiac patients was also assessed [20], and recent studies have proved the prognostic value of MCG maps in diagnosing in-stent restenosis [21] or the 3-year mortality in patients presenting with acute chest pain but without ST segment elevation in the ECG [22]. All these finding demonstrate that MCG and the related diagnostic methods and parameters may be a useful tool for the early detection of CAD.…”

Unshielded magnetocardiography: Repeatability and reproducibility of automatically estimated ventricular repolarization parameters in 204 healthy subjects

“…MCG is a contactless alternative for faster mass screening (Mäkijärvi et al., ; Malmivuo, ; Steinhoff et al., ; Tavarozzi, Comani, Del Gratta, Romani et al., ; Wu et al., ) and radiation‐ and risk‐free method for three‐dimensional electro‐anatomical imaging through passive detection of CMF (Agarwal et al., ; Brisinda et al., ; Brockmeier et al., ; Fenici, Brisinda, Meloni, Sternickel, & Fenici, ; Hailer, Van Leeuwen et al., ; Kandori et al., ; Kwon et al., ; Kwong et al., ; Leithäuser et al., ; Li et al., ; Lim et al., ; Ogata et al., ; Park & Hill, ; Park et al., , ; Shin et al., ; Steinisch et al., ; Tolstrup et al., ; Wu et al., ), which is directly related primary electrophysiological source (the impressed current), thus containing information undetectable with ECG (Fenici, Brisinda, & Meloni, ; Tavarozzi, Comani, Del Gratta, Di Luzio et al., ). VR analysis is considered one of the most useful applications of MCG, mainly to recognize ischemic, inflammatory, or degenerative abnormalities (Tavarozzi, Comani, Del Gratta, Di Luzio et al., ).…”

“…Compared to the electrocardiogram (ECG), MCG provides additional information, being CMF less affected by tissue conductivities, and is more sensitive to tangential currents, and capable to detect vortex currents too (Brockmeier et al., ; Fenici Brisinda, & Meloni ). Although mainly confined in research laboratories, MCG is increasingly used to study cardiac arrhythmias (Fenici, Brisinda, Venuti, & Sorbo, ; Fenici, Brisinda, & Meloni, ; Kwong, Leithäuser, Park, & Yu, ; Mäkijärvi et al., ) and ventricular repolarization (VR) abnormalities (VRa) due to different cardiopathy (Kawakami et al., ), especially ischemic heart disease (IHD) (Agarwal, Saini, Alyousef, & Umscheid, ; Brisinda, Bottelli, Napolitano, Priori, & Fenici, ; Fenici, Brisinda, Meloni, Sternickel, & Fenici, ; Hailer, Chaikovsky, Auth‐Eisernitz, Schäfer, & Van Leeuwen, ; Kandori et al., ; Kwon et al., ; Leithäuser, Park, Hill, Lam, & Jung, ; Li et al., ; Lim et al., ; Ogata et al., ; Park & Hill, ; Park, Leithäuser, Hill, & Jung, ; Park et al., ; Shin et al., ; Steinisch et al., ; Tolstrup et al., ; Wu et al., ).…”