Resting-state brain connectivity in patients with Parkinson's disease and freezing of gait

Tessitore, Alessandro; Amboni, Marianna; Esposito, Fabrizio; Russo, Antonio; Picillo, Marina; Marcuccio, Laura; Pellecchia, Maria Teresa; Vitale, Carmine; Cirillo, Mario; Tedeschi, Gioacchino; Barone, Paolo

doi:10.1016/j.parkreldis.2012.03.018

Cited by 234 publications

(213 citation statements)

References 30 publications

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“…132 Previous evidence showed a resting state functional connectivity disruption of "executive attention" and visual neural networks in association with the presence of freezing of gait in PD. 134 Indeed, this data further strengthened the relationship between gait and cognition in PD. 134 PD pathology leads to volumetric changes in the brain.…”

Section: Csf Biomarkerssupporting

confidence: 53%

“…134 Indeed, this data further strengthened the relationship between gait and cognition in PD. 134 PD pathology leads to volumetric changes in the brain. A study investigated the pattern of gray matter changes according to disease progression in 89 patients with PD and detected decreased gray matter volume in the fronto-temporoparietal areas and the bilateral caudate and increased gray matter volume in the bilateral limbic/paralimbic areas, medial globus pallidus/putamen, and the right occipital cortex as compared with healthy controls.…”

Section: Csf Biomarkerssupporting

confidence: 53%

See 1 more Smart Citation

Biomarkers of Parkinson's disease: recent insights, current challenges, and future prospects

Picillo¹,

Moccia²,

Spina³

et al. 2016

JPRLS

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Section: Csf Biomarkerssupporting

confidence: 53%

Section: Csf Biomarkerssupporting

confidence: 53%

Biomarkers of Parkinson's disease: recent insights, current challenges, and future prospects

Picillo¹,

Moccia²,

Spina³

et al. 2016

JPRLS

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“…An Rs-fMRI study has revealed disturbed functional connectivity between the prefrontal cortex and the putamen [49]. Reduced functional connectivity in the middle frontal, angular, and occipito-temporal gyri have been observed in patients with freezing of gait [50]. Degeneration has also been seen in frontal white matter, especially in subjects with gait difficulties [51].…”

Section: Discussionmentioning

confidence: 99%

Disrupted Brain Network Hubs in Subtype-Specific Parkinson's Disease

Chen

et al. 2017

Eur Neurol

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Background/Aims: The topological organization of brain functional networks is impaired in Parkinson's disease (PD). However, the altered patterns of functional network hubs in different subtypes of PD are not completely understood. Methods: 3T resting-state functional MRI and voxel-based graph-theory analysis were employed to systematically investigate the intrinsic functional connectivity patterns of whole-brain networks. We enrolled 31 patients with PD (12 tremor dominant [TD] and 19 with postural instability/gait difficulty [PIGD]) and 22 matched healthy controls. Whole-brain voxel-wise functional networks were constructed by measuring the temporal correlations of each pair of brain voxels. Functional connectivity strength was calculated to explore the brain network hubs. Results: We found that both the TD and PIGD subtypes had comprehensive disrupted regions. These mainly involved the basal ganglia, cerebellum, superior temporal gyrus, pre- and postcentral gyri, inferior frontal gyrus, middle temporal gyrus, lingual gyrus, insula, and parahippocampal gyrus. Furthermore, the PIGD subgroup had more disrupted hubs in the cerebellum than the TD subgroup. These disruptions of hub connectivity were not correlated with the HY stage or disease duration. Conclusion: Our results emphasize the subtype-specific PD-related degeneration of brain hubs, providing novel insights into the pathophysiological mechanisms of connectivity dysfunction in different PD subgroups.

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“…frontal, central, parietal, and occipital) by taking the mean of each related electrode in those regions and between electrode locations in subregions of interest, namely fronto-parietal regions (F3, Fz, F4, P3, P4) locations often associated with "executive-attention" and visual networks affected by in PD patients with FOG [12]. Squared generalized partial directed coherence (sGPDC) was used to describe the dynamics of the interactions between brain areas as it provides the best indication of FOG compare to several other methods [7].…”

Section: B Feature Extractionmentioning

confidence: 99%

An EEG study of turning freeze in Parkinson's disease patients: The alteration of brain dynamic on the motor and visual cortex

Handojoseno

Gilat

et al. 2015

2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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Abstract-Freezing of gait is a very debilitating symptom affecting many patients with Parkinson's disease, leading to a reduced mobility and increased risk for falls. Turning is known to be the most provocative trigger for freezing of gait. However, the underlying brain dynamic changes associated with a turning freeze remain unknown. This study therefore used ambulatory EEG to investigate the brain dynamic changes associated with freezing of gait during turning. In addition, this study aimed to determine the most suitable EEG sensor location to detect freezing of gait during turning using our classification system. Data from four Parkinson's disease patients with freezing of gait was analysed using power spectral density and brain effective connectivity, comparing periods of successful turning with freezing of gait during turning. Results showed that freezing of gait during turning is associated with significant alterations in the high beta and theta power spectral densities across the occipital and parietal areas. Furthermore, brain effective connectivity showed that freezing during turning was associated with increased connectivity towards the visual area, which also had the highest accuracy to detect freezing episodes in the O1 regions by using power spectral density in our classification analyses. This is the first study to show cortical dynamic changes associated with freezing of gait during turning, providing valuable information to enhance the performance of future freezing of gait detection systems.

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Resting-state brain connectivity in patients with Parkinson's disease and freezing of gait

Cited by 234 publications

References 30 publications

Biomarkers of Parkinson's disease: recent insights, current challenges, and future prospects

Biomarkers of Parkinson's disease: recent insights, current challenges, and future prospects

Disrupted Brain Network Hubs in Subtype-Specific Parkinson's Disease

An EEG study of turning freeze in Parkinson's disease patients: The alteration of brain dynamic on the motor and visual cortex

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Resting-state brain connectivity in patients with Parkinson's disease and freezing of gait

Cited by 234 publications

References 30 publications

Biomarkers of Parkinson&#39;s disease: recent insights, current challenges, and future prospects

Biomarkers of Parkinson&#39;s disease: recent insights, current challenges, and future prospects

Disrupted Brain Network Hubs in Subtype-Specific Parkinson's Disease

An EEG study of turning freeze in Parkinson's disease patients: The alteration of brain dynamic on the motor and visual cortex

Contact Info

Product

Resources

About

Biomarkers of Parkinson's disease: recent insights, current challenges, and future prospects

Biomarkers of Parkinson's disease: recent insights, current challenges, and future prospects