2019
DOI: 10.1016/j.parkreldis.2018.12.016
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Resting-state fMRI in Parkinson's disease patients with cognitive impairment: A meta-analysis

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Cited by 146 publications
(118 citation statements)
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“…In recent years, an intrinsic aberrant functional connectivity within the DMN has been implicated in cognitive processing in several neurodegenerative disorders [93][94][95]. A recent meta-analysis showed that decreased functional connectivity within the DMN is the most consistent finding able to differentiate PD patients with and without cognitive impairment [96]. In a cohort of early-stage cognitively unimpaired patients with PD, we demonstrated the presence of a decreased medial temporal and inferior parietal connectivity within the DMN, which was correlated with cognitive performances [97].…”
Section: Premotor Phase and Non-motor Symptoms Correlatesmentioning
confidence: 99%
“…In recent years, an intrinsic aberrant functional connectivity within the DMN has been implicated in cognitive processing in several neurodegenerative disorders [93][94][95]. A recent meta-analysis showed that decreased functional connectivity within the DMN is the most consistent finding able to differentiate PD patients with and without cognitive impairment [96]. In a cohort of early-stage cognitively unimpaired patients with PD, we demonstrated the presence of a decreased medial temporal and inferior parietal connectivity within the DMN, which was correlated with cognitive performances [97].…”
Section: Premotor Phase and Non-motor Symptoms Correlatesmentioning
confidence: 99%
“…Importantly, two hubs of this network, namely the temporal pole and posterior cingulate cortex, are affected in semantic dementia (Acosta-Cabronero et al, 2011) and Alzheimer's disease (Buckner et al, 2008), respectively, implying that the dysregulation of this network may also be a harbinger of cognitive decline. This is supported by a parietotemporal pattern of atrophy that has been associated with worse cognitive performance in nondemented PD subjects (Uribe et al, 2016;2018), as well as correlation between cognitive impairment in PD and reduced functional connectivity in the default mode network, and frontoparietal and temporal regions (Wolters et al, 2019).…”
Section: Discussionmentioning
confidence: 82%
“…Early study has observed DMN dysfunction in PD patients [24]. Wolters et al [25] observed that cognitive impairment in PD was correlated with reduced FC in networks involved in cognition, especially in the DMN. Studies suggested that the precuneus was implicated in high-level cognitive functions, including self-related processing, episodic memory, and aspects of consciousness [26][27][28].…”
Section: Discussionmentioning
confidence: 99%