Resting-state fMRI study on drug-naive patients with Parkinson's disease and with depression

Chen, Luo; Chen, Qin; Song, Wei; Chen, Ke; Guo, Xiaoyan; Yang, Jing; Huang, Xiaoqi; Gong, Qiyong; Shang, Huifang

doi:10.1136/jnnp-2013-306237

Cited by 88 publications

(75 citation statements)

References 39 publications

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“…More recent striatal connectivity studies have supported some of these findings, such as decreased corticostriatal functional connectivity with the putamen in PD (Luo et al, 2014). However, there have also been important differences.…”

Section: Neuroimaging Of Pdmentioning

confidence: 81%

“…Vriend et al (2014a) reviewed neuroimaging studies of depression in PD and highlighted decreased dopaminergic function in the ventral striatum. MRI studies of co-morbid depression in PD have also shown alterations in ALFF and morphometric result although they are notable for some inconsistent results in ALFF results (Luo et al, 2014a; Skidmore et al, 2013b; Wen et al, 2013) and morphometric studies (Surdhar et al, 2012; van Mierlo et al, 2015). …”

Section: Neuroimaging Of Pdmentioning

confidence: 99%

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Neuroimaging of Parkinson's disease: Expanding views

Weingarten

Sundman

Hickey

et al. 2015

Neuroscience & Biobehavioral Reviews

139

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Advances in molecular and structural and functional neuroimaging are rapidly expanding the complexity of neurobiological understanding of Parkinson’s disease (PD). This review article begins with an introduction to PD neurobiology as a foundation for interpreting neuroimaging findings that may further lead to more integrated and comprehensive understanding of PD. Diverse areas of PD neuroimaging are then reviewed and summarized, including positron emission tomography, single photon emission computed tomography, magnetic resonance spectroscopy and imaging, transcranial sonography, magnetoencephalography, and multimodal imaging, with focus on human studies published over the last five years. These included studies on differential diagnosis, co-morbidity, genetic and prodromal PD, and treatments from L-DOPA to brain stimulation approaches, transplantation and gene therapies. Overall, neuroimaging has shown that PD is a neurodegenerative disorder involving many neurotransmitters, brain regions, structural and functional connections, and neurocognitive systems. A broad neurobiological understanding of PD will be essential for translational efforts to develop better treatments and preventive strategies. Many questions remain and we conclude with some suggestions for future directions of neuroimaging of PD.

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Section: Neuroimaging Of Pdmentioning

confidence: 81%

Section: Neuroimaging Of Pdmentioning

confidence: 99%

Neuroimaging of Parkinson's disease: Expanding views

Weingarten

Sundman

Hickey

et al. 2015

Neuroscience & Biobehavioral Reviews

139

View full text Add to dashboard Cite

show abstract

“…Of the 38 studies on depression, 33 reported findings from one single imaging modality: 19 used either PET [11, 12, 13,15, 16, 17, 18, 19] or SPECT 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30 techniques, four used T1‐weighted imaging 31, 32, 33, three used DTI 34, 35, 36, six used resting state functional MRI (RS‐FMRI) 37, 38, 39, 40, 41, 42 and two used TCS methods 43, 44. The remaining four of the 38 studies reported findings from structural T1‐weighted imaging plus another imaging method, including PET 14, DTI 45, task FMRI 46 and RS‐FMRI 47, respectively.…”

Section: Methodsmentioning

confidence: 99%

Depression, anxiety, and apathy in Parkinson's disease: insights from neuroimaging studies

Wen

Chan

Tan

et al. 2016

Euro J of Neurology

150

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Depression, anxiety and apathy are common mood disturbances in Parkinson's disease (PD) but their pathophysiology is unclear. Advanced neuroimaging has been increasingly used to unravel neural substrates linked to these disturbances. A systematic review is provided of neuroimaging findings in depression, anxiety and apathy in PD. A PubMed, MEDLINE and EMBASE search of peer‐reviewed original research articles on these mood disturbances in PD identified 38 studies on depression, eight on anxiety and 14 on apathy in PD. Most of the imaging studies used either position emission tomography or single‐photon emission computed tomography techniques. These studies generally suggest increased neural activity in the prefrontal regions and decreased functional connectivity between the prefrontal−limbic networks in depressed patients. Functional imaging studies revealed an inverse correlation between dopaminergic density in the caudate and putamen with the severity of anxiety in PD. There was no consistent correlation between dopaminergic density of thalamus and anxiety. Studies demonstrated both positive and inverse correlations between apathy and metabolism or activity in the striatum, amygdalar, prefrontal, temporal and parietal regions. The clinical variability of study subjects and differences in image pre‐processing and analytical strategies may contribute to discrepant findings in these studies. Both nigrostriatal and extra‐nigrostriatal pathways (in particular the frontal region and its connecting areas) are affected in mood disorders in PD. Identifying the relative contributions of these neural pathways in PD patients with overlapping motor and mood symptoms could provide new pathophysiological clues for the development of better therapeutic targets for affected patients.

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“…Accordingly, structural neuroimaging techniques have shown gray matter loss and white matter abnormalities in the prefrontal, temporal, and some limbic regions in depressed PD patients [ 28 , 29 ]. Finally a very recent resting-state functional magnetic resonance study (RS fMRI) revealed reduced functional connectivity in the prefrontal-limbic network in PD patients with depression as compared with PD patients without [ 30 ].…”

Section: Pathophysiologymentioning

confidence: 97%

Depression, Apathy, Anhedonia, and Fatigue in Parkinson’s Disease

Amboni

Santangelo

Barone

2014

Neuropsychiatric Symptoms of Movement Disorders

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Depression in PD Defi nition and Pathophysiology Defi nitionDepression is a common neuropsychiatric disorder characterized by the persistence and pervasiveness of a spectrum of symptoms that can variously aggregate. These symptoms include: depressed mood, loss of interest/pleasure, loss or gain in weight or appetite, insomnia or hypersomnia, psychomotor agitation, fatigue, feelings of worthlessness or guilt, diminished ability to think or concentrate, indecisiveness, thoughts of death, and suicidal ideation.

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Resting-state fMRI study on drug-naive patients with Parkinson's disease and with depression

Cited by 88 publications

References 39 publications

Neuroimaging of Parkinson's disease: Expanding views

Neuroimaging of Parkinson's disease: Expanding views

Depression, anxiety, and apathy in Parkinson's disease: insights from neuroimaging studies

Depression, Apathy, Anhedonia, and Fatigue in Parkinson’s Disease

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