Resting-state functional connectivity in women with Major Depressive Disorder

Buchanan, A. R.; Wang, Xue; Gollan, Jackie K.

doi:10.1016/j.jpsychires.2014.09.002

Cited by 24 publications

(14 citation statements)

References 66 publications

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“…A meta-analysis revealed that MDD was characterized by hypoconnectivity within the FPN, and associated with hyperconnectivity between frontoparietal control systems and regions of the DMN[ 56 ]. Moreover, a significantly decreased connectivity in the bilateral frontoparietal regions in MDD compared to HC was also found in a previous study[ 57 ], suggesting frontoparietal region might be a key region related to pathomechanism of depression. Meanwhile, the ReHo value was calculated depended on the regional cerebral blood flow (rCBF).…”

Section: Discussionsupporting

confidence: 81%

Identify changes of brain regional homogeneity in early and later adult onset patients with first-episode depression using resting-state fMRI

et al. 2017

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ObjectivePrevious work exhibited different brain grey matter volume (GMV) changes between patients with early adult onset depression (EOD, age 18–29) and later adult onset depression (LOD, age 30–44) by using 30-year-old as the cut-off age. To identify whether regional homogeneity (ReHo) changes are also different between EOD and LOD by using same cut-off age, we used resting-state functional magnetic resonance imaging (fMRI) to detect the abnormal ReHo between patients with EOD and LOD in the present study.MethodsResting-state fMRI scans of 58 patients with EOD, 62 patients with LOD, 60 young healthy controls (HC), and 52 old HC were obtained. The ReHo approach was used to analyze the images.ResultsThe ANOVA analysis revealed that the ReHo values in the frontoparietal, occipital, and cerebellar regions were significantly different among the four groups. Relative to patients with LOD, patients with EOD displayed significantly increased ReHo in the left precuneus, and decreased ReHo in the right fusiform. The ReHo values in the left precuneus and the right fusiform had no significant correlation with the score of the depression rating scale or illness duration in both patient subgroups. Compared to young HC, patients with EOD showed significantly increased ReHo in the right frontoparietal regions and the right calcarine. Furthermore, the increased ReHo in the right frontoparietal regions, right insula and left hippocampus, and decreased ReHo in the left inferior occipital gyrus, right middle occipital gyrus, left calcarine, and left supplementary motor area were observed in patients with LOD when compared to old HC.ConclusionsThe ReHo of brain areas that were related to mood regulation was changed in the first-episode, drug-naive adult patients with MDD. Adult patients with EOD and LOD exhibited different ReHo abnormalities relative to each age-matched comparison group, suggesting that depressed adult patients with different age-onset might have different pathological mechanism.

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Section: Discussionsupporting

confidence: 81%

Identify changes of brain regional homogeneity in early and later adult onset patients with first-episode depression using resting-state fMRI

et al. 2017

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“…The final sample (N ¼ 112) included 51 female participants meeting criteria for MDD and 61 healthy comparison females (HC) who were part of a large study of depression in women across the lifespan. A similar dataset from this study demonstrated differential activation during rest in the depressed participants (Buchanan et al, 2014).…”

Section: Participantssupporting

confidence: 73%

Reduced striatal activation in females with major depression during the processing of affective stimuli

Connolly

Gollan

Cobia

et al. 2015

Journal of Psychiatric Research

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“…A decrease in functional connectivity of the prefrontal and supramarginal gyri has been previously reported in depression; 44 it was negatively correlated with the ventral attention threat bias; 45 and MDD patients exhibited a different pattern of brain network organization and specifically higher degree, that is, number of connections, in the left SMG. 46 Given the functional importance of the SMG at the interface of cognitive and social processing and the results of our study identifying DLPFC/SMG connectivity significance in both analyses, the group comparison (StD vs control) and the regression with CES-D scores across all subjects, we speculate that the decreased rs-FC between the DLPFC and SMG may be primarily associated with the cognitive functions impairment (attention, memory and executive control), as well as cognitive biases experienced by the StD subjects such as increased self-focus and negative thoughts.…”

Section: Discussionmentioning

confidence: 55%

Subthreshold depression is associated with impaired resting-state functional connectivity of the cognitive control network

et al. 2015

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Subthreshold depression (StD) is a prevalent condition associated with social morbidity and increased service utilization, as well as a high risk of developing into a major depressive disorder (MDD). The lack of well-defined diagnostic criteria for StD has limited research on this disorder, with very few brain-imaging studies examining the neurobiology of StD. Yet, identifying the neural pathology of StD has the potential to elucidate risk factors and prognostic markers for major depression and is crucial for developing tailored treatments for patients at mild stages of depression. We investigated resting-state functional connectivity (rs-FC) of the cognitive control network (CCN), known to be dysregulated in MDD, using the bilateral dorsolateral prefrontal cortex (DLPFC) as a seed, focusing on two cohorts of StD subjects (young and middle aged) as well as matched controls. Irrespective of age, we found a significant rs-FC decrease in the CCN of the StD subjects, compared with matched controls, particularly between the DLPFC and the brain regions associated with the representation of self and other mental states (temporo-parietal junction (TPJ) and precuneus), as well as salience detection and orienting (insula). The functional connectivity between the DLPFC and the left TPJ was also associated with depressive symptom scores measured by the Center for Epidemiologic Studies Depression Scale. This finding may shed light on the neural pathology of StD, leading to better understanding of mild stages of depression, its diagnosis and the development of new treatments.

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Resting-state functional connectivity in women with Major Depressive Disorder

Cited by 24 publications

References 66 publications

Identify changes of brain regional homogeneity in early and later adult onset patients with first-episode depression using resting-state fMRI

Identify changes of brain regional homogeneity in early and later adult onset patients with first-episode depression using resting-state fMRI

Reduced striatal activation in females with major depression during the processing of affective stimuli

Subthreshold depression is associated with impaired resting-state functional connectivity of the cognitive control network

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