Resting-State Functional Magnetic Resonance Imaging Activity and Connectivity and Cognitive Outcome in Traumatic Brain Injury

Palacios, Eva M.; Sala‐Llonch, Roser; Junqué, Carme; Roig, Teresa; Tormos, J.M.; Bargalló, Núria; Vendrell, Pere

doi:10.1001/jamaneurol.2013.38

Cited by 150 publications

(110 citation statements)

References 36 publications

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“…27,28,32 Mayer and associates 27 attributed this abnormality to the partial disruption of the putative balance between the DMN and task-related networks after mTBI, and Stevens and colleagues 32 interpreted this abnormality as a compensatory process of the brain. Palacios and coworkers 48 also attribute this to a compensatory process after microstructural damage to the brain, as detected by DTI. In addition, by considering the hyperconnectivity in thalamocortical network, hippocampal network, and amygdala network, our data also support the hypothesis by Stevens and colleagues 32 that multiple RSNs could have functional abnormalities after mTBI.…”

Section: Dmnmentioning

confidence: 92%

Resting State Functional Connectivity in Mild Traumatic Brain Injury at the Acute Stage: Independent Component and Seed-Based Analyses

Iraji

Benson

Welch

et al. 2015

Journal of Neurotrauma

139

109

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Mild traumatic brain injury (mTBI) accounts for more than 1 million emergency visits each year. Most of the injured stay in the emergency department for a few hours and are discharged home without a specific follow-up plan because of their negative clinical structural imaging. Advanced magnetic resonance imaging (MRI), particularly functional MRI (fMRI), has been reported as being sensitive to functional disturbances after brain injury. In this study, a cohort of 12 patients with mTBI were prospectively recruited from the emergency department of our local Level-1 trauma center for an advanced MRI scan at the acute stage. Sixteen age-and sex-matched controls were also recruited for comparison. Both group-based and individual-based independent component analysis of resting-state fMRI (rsfMRI) demonstrated reduced functional connectivity in both posterior cingulate cortex (PCC) and precuneus regions in comparison with controls, which is part of the default mode network (DMN). Further seed-based analysis confirmed reduced functional connectivity in these two regions and also demonstrated increased connectivity between these regions and other regions of the brain in mTBI. Seedbased analysis using the thalamus, hippocampus, and amygdala regions further demonstrated increased functional connectivity between these regions and other regions of the brain, particularly in the frontal lobe, in mTBI. Our data demonstrate alterations of multiple brain networks at the resting state, particularly increased functional connectivity in the frontal lobe, in response to brain concussion at the acute stage. Resting-state functional connectivity of the DMN could serve as a potential biomarker for improved detection of mTBI in the acute setting.

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Section: Dmnmentioning

confidence: 92%

Resting State Functional Connectivity in Mild Traumatic Brain Injury at the Acute Stage: Independent Component and Seed-Based Analyses

Iraji

Benson

Welch

et al. 2015

Journal of Neurotrauma

139

109

View full text Add to dashboard Cite

show abstract

“…During the last decade, numerous studies have already evaluated functional networks in brain-injured patients by using seed-based functional connectivity (Palacios et al, 2013;Tang et al, 2011) or independent component analysis (ICA) (Sharp et al, 2011;Shumskaya et al, 2012) in restingstate functional MRI (rs-fMRI). Nevertheless, such studies are limited by a restricted choice of a priori regions-of-interest (seed regions), which can underestimate the complexity of relationships assessed across the whole brain.…”

mentioning

confidence: 99%

Functional Connectivity Density and Balance in Young Patients with Traumatic Axonal Injury

et al. 2015

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Our previous study provided some evidence for the relationship between abnormal structural connectivity and poor balance performance in young traumatic axonal injury (TAI) patients. An enhanced understanding of the functional connectivity following TAI may allow targeted treatments geared toward improving brain function and postural control. Twelve patients with TAI and 28 normally developing children (aged 9-19 years) performed the sensory organization test (SOT) protocol of the EquiTest (Neurocom). All participants were scanned using resting-state functional magnetic resonance imaging series along with anatomical scans. We applied ''functional connectivity density mapping'' (FCDM), a voxel-wise data-driven method that calculates individual functional connectivity maps to obtain both short-range and long-range FCD. Findings revealed that the TAI group scored generally lower than the control group on the SOT, especially when proprioceptive feedback was compromised. Between-group maps noted significantly decreased long-range FCD in the TAI group in frontal and subcortical regions and significantly increased short-range FCD in frontal regions, left inferior parietal, and cerebellar lobules. Moreover, lower balance levels in TAI patients were associated with a lower long-range FCD in left putamen and cerebellar vermis. These findings suggest that long-range connections may be more vulnerable to TAI than short-range connections. Moreover, higher values of short-range FCD may suggest adaptive mechanisms in the TAI group. Finally, this study supports the view that FCDM is a valuable tool for selectively predicting functional motor deficits in TAI patients.

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“…TBI is not one disorder; rather, it is a heterogeneous mix of brain injuries and associated deficits. There is increasing recognition of the importance in recognizing brain network abnormalities related to altered functional 117,143 and structural 130 abnormalities in TBI patients. Given the expanding view of the potential to modulate functional brain networks with spatially precise DBS delivery, 89 structural and functional neuroimaging studies should be used in future TBI trials to target biomarkers of functional deficits in a patient-specific fashion.…”

Section: Discussionmentioning

confidence: 99%

Neurostimulation for traumatic brain injury

Shin

Dixon²,

Okonkwo³

et al. 2014

JNS

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Traumatic brain injury (TBI) remains a significant public health problem and is a leading cause of death and disability in many countries. Durable treatments for neurological function deficits following TBI have been elusive, as there are currently no FDA-approved therapeutic modalities for mitigating the consequences of TBI. Neurostimulation strategies using various forms of electrical stimulation have recently been applied to treat functional deficits in animal models and clinical stroke trials. The results from these studies suggest that neurostimulation may augment improvements in both motor and cognitive deficits after brain injury. Several studies have taken this approach in animal models of TBI, showing both behavioral enhancement and biological evidence of recovery. There have been only a few studies using deep brain stimulation (DBS) in human TBI patients, and future studies are warranted to validate the feasibility of this technique in the clinical treatment of TBI. In this review, the authors summarize insights from studies employing neurostimulation techniques in the setting of brain injury. Moreover, they relate these findings to the future prospect of using DBS to ameliorate motor and cognitive deficits following TBI.

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Resting-State Functional Magnetic Resonance Imaging Activity and Connectivity and Cognitive Outcome in Traumatic Brain Injury

Cited by 150 publications

References 36 publications

Resting State Functional Connectivity in Mild Traumatic Brain Injury at the Acute Stage: Independent Component and Seed-Based Analyses

Resting State Functional Connectivity in Mild Traumatic Brain Injury at the Acute Stage: Independent Component and Seed-Based Analyses

Functional Connectivity Density and Balance in Young Patients with Traumatic Axonal Injury

Neurostimulation for traumatic brain injury

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