Resting state network plasticity related to picture naming in low-grade glioma patients before and after resection

Dokkum, Liesjet van; Gasser, Sylvie Moritz; Deverdun, Jérémy; Herbet, Guillaume; Mura, Thibault; D'Agata, Bénédicte; Picot, Marie‐Christine; Champfleur, Nicolas Menjot de; Duffau, Hugues; Molino, François; Bars, Emmanuelle Le

doi:10.1016/j.nicl.2019.102010

Cited by 28 publications

(30 citation statements)

References 42 publications

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“…DLGG is a slow-growing primary brain tumor and is associated with marked functional plasticity ( 15 ). DLGG facilitates reorganization of functional networks adjacent to the tumor ( 16 – 18 ), resulting in increased FC ( 19 ). In our study, gliomas were located in the left temporal lobe, which is close to the visual network.…”

Section: Discussionmentioning

confidence: 99%

Epilepsy-Related Brain Network Alterations in Patients With Temporal Lobe Glioma in the Left Hemisphere

et al. 2020

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Background: Seizures are a common symptom in patients with temporal lobe gliomas and may result in brain network alterations. However, brain network changes caused by glioma-related epilepsy (GRE) remain poorly understood. Objective: In this study, we applied graph theory analysis to delineate topological networks with resting-state functional magnetic resonance images (rs-fMRI) and investigated characteristics of functional networks in patients with GRE. Methods: Thirty patients with low-grade gliomas in the left temporal lobe were enrolled and classified into GRE (n = 15) and non-GRE groups. Twenty healthy participants matched for age, sex, and education level were enrolled. All participants had rs-fMRI data. Sensorimotor, visual, default mode, auditory, and right executive control networks were used to construct connection matrices. Topological properties of those sub-networks were investigated. Results: Compared to that in the GRE group, four edges with higher functional connectivity were noted in the non-GRE group. Moreover, 21 edges with higher functional connectivity were identified in the non-GRE group compared to the healthy group. All significant alterations in functional edges belong to the visual network. Increased global efficiency and decreased shortest path lengths were noted in the non-GRE group compared to the GRE and healthy groups. Compared with that in the healthy group, nodal efficiency of three nodes was higher in the GRE and non-GRE groups and the degree centrality of six nodes was altered in the non-GRE group. Conclusion: Temporal lobe gliomas in the left hemisphere and GRE altered visual networks in an opposing manner. These findings provide a novel insight into brain network alterations induced by GRE.

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Section: Discussionmentioning

confidence: 99%

Epilepsy-Related Brain Network Alterations in Patients With Temporal Lobe Glioma in the Left Hemisphere

et al. 2020

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“…Beyond the language network itself, post-lesional recovery also depends on the integration and interaction of hubs not only within but also between multiple neural circuits, in agreement with the principle of variable neuro-displacement described in recovery from post-stroke aphasia [ 55 ]. Indeed, picture naming compensation relied on both the engagement of the semantic network and the fronto-parietal attentional network, as supported by an increased connectivity between the right superior parietal lobe and the right frontal operculum [ 116 ].…”

Section: Functional Compensation After Lgg Surgery: Postoperative mentioning

confidence: 99%

Functional Mapping before and after Low-Grade Glioma Surgery: A New Way to Decipher Various Spatiotemporal Patterns of Individual Neuroplastic Potential in Brain Tumor Patients

Duffau

2020

Cancers

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Intraoperative direct electrostimulation mapping (DEM) is currently the gold-standard for glioma surgery, since functional-based resection allows an optimization of the onco-functional balance (increased resection with preserved quality of life). Besides intrasurgical awake mapping of conation, cognition, and behavior, preoperative mapping by means of functional neuroimaging (FNI) and transcranial magnetic stimulation (TMS) has increasingly been utilized for surgical selection and planning. However, because these techniques suffer from several limitations, particularly for direct functional mapping of subcortical white matter pathways, DEM remains crucial to map neural connectivity. On the other hand, non-invasive FNI and TMS can be repeated before and after surgical resection(s), enabling longitudinal investigation of brain reorganization, especially in slow-growing tumors like low-grade gliomas. Indeed, these neoplasms generate neuroplastic phenomena in patients with usually no or only slight neurological deficits at diagnosis, despite gliomas involving the so-called “eloquent” structures. Here, data gained from perioperative FNI/TMS mapping methods are reviewed, in order to decipher mechanisms underpinning functional cerebral reshaping induced by the tumor and its possible relapse, (re)operation(s), and postoperative rehabilitation. Heterogeneous spatiotemporal patterns of rearrangement across patients and in a single patient over time have been evidenced, with structural changes as well as modifications of intra-hemispheric (in the ipsi-lesional and/or contra-lesional hemisphere) and inter-hemispheric functional connectivity. Such various fingerprints of neural reconfiguration were correlated to different levels of cognitive compensation. Serial multimodal studies exploring neuroplasticity might lead to new management strategies based upon multistage therapeutic approaches adapted to the individual profile of functional reallocation.

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“…Additionally, previous studies have suggested that the alterations in functional networks may be associated with neuroplasticity in DLGG patients. For instance, van Dokkum et al reported that the right inferior parietal lobe compensated for impaired language function in DLGG patients through the reorganization of attention networks 24 .…”

Section: Discussionmentioning

confidence: 99%

Contralesional functional network reorganization of the insular cortex in diffuse low-grade glioma patients

Sun

Zhou

Wang

et al. 2021

Sci Rep

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Diffuse low-grade gliomas (DLGGs) growing on the insular lobe induce contralesional hemispheric insular lobe compensation of damaged functioning by increasing cortical volumes. However, it remains unclear how functional networks are altered in patients with insular lobe DLGGs during functional compensation. Thirty-five patients with insular DLGGs were classified into the left (insL, n = 16) and right groups (insR, n = 19), and 33 healthy subjects were included in the control group. Resting state functional magnetic resonance imaging was used to generate functional connectivity (FC), and network topological properties were evaluated using graph theoretical analysis based on FC matrices. Network-based statistics were applied to compare differences in the FC matrices. A false discovery rate was applied to correct the topological properties. There was no difference in the FC of edges between the control and insL groups; however, the nodal shortest path length of the right insular lobe was significantly increased in the insL group compared to the control group. Additionally, FC was increased in the functional edges originating from the left insular lobe in the insR group compared to the control group. Moreover, there were no differences in topological properties between the insR and control groups. The contralesional insular lobe is crucial for network alterations. The detailed patterns of network alterations were different depending on the affected hemisphere. The observed network alterations might be associated with functional network reorganization and functional compensation.

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Resting state network plasticity related to picture naming in low-grade glioma patients before and after resection

Cited by 28 publications

References 42 publications

Epilepsy-Related Brain Network Alterations in Patients With Temporal Lobe Glioma in the Left Hemisphere

Epilepsy-Related Brain Network Alterations in Patients With Temporal Lobe Glioma in the Left Hemisphere

Functional Mapping before and after Low-Grade Glioma Surgery: A New Way to Decipher Various Spatiotemporal Patterns of Individual Neuroplastic Potential in Brain Tumor Patients

Contralesional functional network reorganization of the insular cortex in diffuse low-grade glioma patients

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