Resting-State Oscillatory Activity in Autism Spectrum Disorders

Cornew, Lauren; Roberts, Timothy P.L.; Blaskey, Lisa; Edgar, J. Christopher

doi:10.1007/s10803-011-1431-6

Cited by 183 publications

(209 citation statements)

References 55 publications

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“…Our findings are consistent with previous experimental findings in a MEG and EEG studies performed in a non-clinical setting [5,7]. Routine EEG is a commonly available investigation and can be used without sedation across a wider range of age groups and in children with developmental disabilities.…”

Section: Discussionsupporting

confidence: 92%

“…One EEG study has reported an increase in gamma activity during an eyes-open sustained attention task in children with ASD [5], while another found evidence for localized decreased gamma activity using the same EEG paradigm [6]. A recent MEG study found elevated 20-120 Hz activity during an eyes-closed condition predominantly in posterior brain regions [7].…”

Section: Introductionmentioning

confidence: 99%

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Increased power of resting-state gamma oscillations in autism spectrum disorder detected by routine electroencephalography

Diessen

Senders

Jansen

et al. 2014

Eur Arch Psychiatry Clin Neurosci

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Experimental studies suggest that increased resting-state power of gamma oscillations is associated with autism spectrum disorder (ASD). To extend the clinical applicability of this finding, we retrospectively investigated routine electroencephalography (EEG) recordings of 19 patients with ASD and 19 age-and gender-matched controls. Relative resting-state condition gamma spectral power was variable, but on average significantly increased in children with ASD. This effect remained when excluding electrodes associated with myogenic gamma activity. These findings further indicate that increased resting-state gamma activity characterizes a subset of ASD and may also be detected by routine EEG as a clinically accessible and well-tolerated investigation.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Increased power of resting-state gamma oscillations in autism spectrum disorder detected by routine electroencephalography

Diessen

Senders

Jansen

et al. 2014

Eur Arch Psychiatry Clin Neurosci

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“…The baseline decreased resting state a power was consistent with other EEG studies in ASD. 25,26 Moreover, a role for a frequency band oscillations has been shown in specific cognitive mechanisms. 27 The increase in the a frequency power after treatment may be an underlying mechanism of patient's improvement in cognition and behavior.…”

Section: Discussionmentioning

confidence: 99%

Paradoxical Benzodiazepine Response: A Rationale for Bumetanide in Neurodevelopmental Disorders?

Bruining¹,

Passtoors²,

Goriounova

et al. 2015

Pediatrics

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The diuretic agent bumetanide has recently been put forward as a novel, promising treatment of behavioral symptoms in autism spectrum disorder (ASD) and related conditions. Bumetanide can decrease neuronal chloride concentrations and may thereby reinstate g-aminobutyric acid (GABA)-ergic inhibition in patients with neurodevelopmental disorders. However, strategies to select appropriate candidates for bumetanide treatment are lacking. We hypothesized that a paradoxical response to GABA-enforcing agents such as benzodiazepines may predict the efficacy of bumetanide treatment in neurodevelopmental disorders. We describe a case of a 10-year-old girl with ASD, epilepsy, cortical dysplasia, and a 15q11.2 duplication who had exhibited marked behavioral arousal after previous treatment with clobazam, a benzodiazepine. We hypothesized that this response indicated the presence of depolarizing excitatory GABA and started bumetanide treatment with monitoring of behavior, cognition, and EEG. The treatment resulted in a marked clinical improvement in sensory behaviors, rigidity, and memory performance, which was substantiated by questionnaires and cognitive assessments. At baseline, the girl's EEG showed a depression in absolute a power, an electrographic sign previously related to ASD, which was normalized with bumetanide treatment. The effects of bumetanide on cognition and EEG seemed to mirror the "nonparadoxical" responses to benzodiazepines in healthy subjects. In addition, temporal lobe epilepsy and cortical dysplasia have both been linked to disturbed chloride homeostasis and seem to support our assumption that the observed paradoxical response was due to GABA-mediated excitation. This case highlights that a paradoxical behavioral response to GABA-enforcing drugs may constitute a framework for targeted treatment with bumetanide. PATIENT PRESENTATIONThe patient, a 10-year-old girl, was the fourth child of nonconsanguineous healthy parents. The family history was unremarkable, and the pregnancy and birth were uneventful. The child displayed an apparently normal development up to 4 years of age, when she began experiencing epileptic seizures. She was diagnosed with focal epilepsy with right temporoparietal localization, with focal seizures occurring in clusters.An MRI revealed a focal cortical dysplasia of the right temporal lobe. Coinciding with the onset of epilepsy, learning difficulty and behavioral rigidity emerged but were not evaluated at that time by a child psychiatrist. At the age of 8 years, she was referred to our clinic for diagnostic evaluation of increasing learning disability, behavioral inflexibility, and emotional disturbance. We observed a delay in language development, rigidity, and repetitive behaviors with peculiar

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“…A recent magnetoencephalography study comparing brain activity in individuals with autism with that in age-matched controls indicated that those with autism have increased resting-state power of multiple frequency bands. 21 Alpha and delta powers were elevated in frontoparietal channels, and increases in the latter have been associated with gray-white matter disconnection. 40 In the study by Cornew and colleagues, 21 broadband gamma power was increased in posterior channels.…”

Section: Electrophysiological Disturbancesmentioning

confidence: 99%

“…21 Alpha and delta powers were elevated in frontoparietal channels, and increases in the latter have been associated with gray-white matter disconnection. 40 In the study by Cornew and colleagues, 21 broadband gamma power was increased in posterior channels. Stimulus-induced electrophysiological changes in autism are not well studied, but EEG studies of pure-tone auditory stimuli in individuals with autism have shown increased event-related potential latency along with deficits in phase-locked gammaband power in the superior temporal gyrus.…”

Section: Electrophysiological Disturbancesmentioning

confidence: 99%

Deep brain stimulation for severe autism: from pathophysiology to procedure

Sinha

McGovern

Sheth

2015

FOC

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Autism is a heterogeneous neurodevelopmental disorder characterized by early-onset impairment in social interaction and communication and by repetitive, restricted behaviors and interests. Because the degree of impairment may vary, a spectrum of clinical manifestations exists. Severe autism is characterized by complete lack of language development and potentially life-threatening self-injurious behavior, the latter of which may be refractory to medical therapy and devastating for affected individuals and their caretakers. New treatment strategies are therefore needed. Here, the authors propose deep brain stimulation (DBS) of the basolateral nucleus of the amygdala (BLA) as a therapeutic intervention to treat severe autism. The authors review recent developments in the understanding of the pathophysiology of autism. Specifically, they describe the genetic and environmental alterations that affect neurodevelopment. The authors also highlight the resultant microstructural, macrostructural, and functional abnormalities that emerge during brain development, which create a pattern of dysfunctional neural networks involved in socioemotional processing. They then discuss how these findings implicate the BLA as a key node in the pathophysiology of autism and review a reported case of BLA DBS for treatment of severe autism. Much progress has been made in recent years in understanding the pathophysiology of autism. The BLA represents a logical neurosurgical target for treating severe autism. Further study is needed that considers mechanistic and operative challenges.

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Resting-State Oscillatory Activity in Autism Spectrum Disorders

Cited by 183 publications

References 55 publications

Increased power of resting-state gamma oscillations in autism spectrum disorder detected by routine electroencephalography

Increased power of resting-state gamma oscillations in autism spectrum disorder detected by routine electroencephalography

Paradoxical Benzodiazepine Response: A Rationale for Bumetanide in Neurodevelopmental Disorders?

Deep brain stimulation for severe autism: from pathophysiology to procedure

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