Restless Leg Syndrome in Peripheral Artery Disease: Prevalence among Patients with Claudication and Benefits from Low-Intensity Exercise

Lamberti, Nicola; López‐Soto, Pablo Jesús; Rodríguez‐Borrego, María Aurora; Straudi, Sofía; Basaglia, Nino; Zamboni, Paolo; Manfredini, Roberto; Manfredini, Fabio

doi:10.3390/jcm8091403

Cited by 3 publications

(2 citation statements)

References 68 publications

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“…This change in exercise capacity was related to an increase in walking speed, a protective factor according to the literature [60,61], as well to an improvement in cardiovascular fitness as calculated peak oxygen consumption, which increased by approximately 6-10% with respect to the individual baseline level. Additional preventive actions are represented by the educational activity on risk factor management developed during the on-site visits by the progressive reintroduction of a more active lifestyle at discharge from rehabilitation and in subjects with limitations [62,63], plus a rapid improvement of night-time leg symptoms with recovery of sleep quality [64].…”

Section: Discussionmentioning

confidence: 99%

Lower All-Cause Mortality Risk in Females and Males with Peripheral Artery Disease following Pain-Free Home-Based Exercise: A 7-Year Observational Study

Lamberti

Traina

Savriè

et al. 2023

JPM

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We evaluated the sex-specific difference in response upon participation in an exercise program with respect to the risk of adverse clinical outcomes among patients with peripheral artery disease (PAD) and claudication. The records of 400 PAD patients were assessed between 2012 and 2015. Two hundred of them were addressed to a walking program prescribed at the hospital and executed at home at symptom-free walking speed (Ex), while the remaining 200 acted as a control group (Co). The number and date of deaths, all-cause hospitalizations, and amputations for a 7-year period were collected from the regional registry. At baseline, no differences were observed (MEXn = 138; FEXn = 62; MCOn = 149; FCOn = 51). The 7-year survival rate was significantly higher in FEX (90%) than in MEX (82% hazard ratio, HR: 0.542 95% CI 0.331–0.885), FCO (45%, HR: 0.164 95% CI 0.088–0.305), and MCO (44%; HR: 0.157 95% CI 0.096–0.256). A significantly lower rate of hospitalization (p < 0.001) and amputations (p = 0.016) was observed for the Ex group compared to the Co group, without differences by sex. In conclusion, in PAD patients, active participation in a home-based pain-free exercise program was associated with a lower rate of death and better long-term clinical outcomes, particularly among women.

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Section: Discussionmentioning

confidence: 99%

Lower All-Cause Mortality Risk in Females and Males with Peripheral Artery Disease following Pain-Free Home-Based Exercise: A 7-Year Observational Study

Lamberti

Traina

Savriè

et al. 2023

JPM

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“…RLS has a deleterious influence on ESRD patient's outcomes getting long-term HD, with sleep and life quality, and is significantly linked with higher rate of mortality [8][9][10][11]. The poor quality of life has been related to the systemic inflammation, but there is paucity of data on RLS with inflammation [12].…”

Section: Introductionmentioning

confidence: 99%

Restless leg syndrome in patients on hemodialysis

Mazharulhaq

Ahmad²,

Arshad³

et al. 2023

ijhs

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Background and Aim: Restless legs syndrome (RLS) is a prevalent neurological disease that is frequently misdiagnosed due to comparable signs and symptoms to other disorders such as diabetes, migraine, and cardiovascular disease. RLS may deteriorate with age, and it is more frequent in women than in males. The incidence of RLS varies from 6.6% to 80% in the general population. The present study aimed to assess the RLS in patients on hemodialysis. Patients and Methods: A questionnaire based study was conducted on 116 consecutive hemodialysis patients in the Department of Neurology and Nephrology of Institute of Kidney Diseases Hayatabad, Peshawar and PAF Hospital, Islamabad for the Duration from June 2022 to December 2022. Patients’ history included a history of drug, predialysis duration, and hemodialysis duration. Data was obtained using a standardized questionnaire that includes demographic variables such as personal history, family history, disease history, and smoking history.

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Potential therapeutic benefit of spinal cord stimulation in restless legs syndrome: scoping review and mechanistic considerations

Pagani-Estévez,

Holland,

Tippmann-Peikert

et al. 2023

Pain Medicine

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Background Restless legs syndrome (RLS) is a prevalent sensorimotor disorder that can dramatically impair sleep quality, daytime function, and quality of life. Although many patients benefit from standard pharmacological therapy, some patients suffer from insufficient treatment response or medication intolerance. Novel treatment approaches are therefore necessary. Objective Given the overlap between RLS and pain syndromes in both pathophysiological mechanisms and certain treatment options, we aimed to perform a scoping review of the available evidence on spinal cord stimulation (SCS) for RLS and discuss potential mechanistic implications. Methods We identified a total of 16 cases of patients with RLS who underwent SCS, all from case reports or case series. Discussion The published evidence is insufficient to assess SCS efficacy in patients with RLS, but SCS remains a promising investigational therapy in RLS on the basis of its potential mitigatory effects in the central hyperexcitability of the sensorimotor cortex through neuromodulation of spinal, subcortical, and cortical areas. A call for further research in this field is presented, with suggestions for future directions and trial designs.

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Restless Leg Syndrome in Peripheral Artery Disease: Prevalence among Patients with Claudication and Benefits from Low-Intensity Exercise

Cited by 3 publications

References 68 publications

Lower All-Cause Mortality Risk in Females and Males with Peripheral Artery Disease following Pain-Free Home-Based Exercise: A 7-Year Observational Study

Lower All-Cause Mortality Risk in Females and Males with Peripheral Artery Disease following Pain-Free Home-Based Exercise: A 7-Year Observational Study

Restless leg syndrome in patients on hemodialysis

Potential therapeutic benefit of spinal cord stimulation in restless legs syndrome: scoping review and mechanistic considerations

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