Restless Legs Syndrome, and symptoms of Restless Syndrome in patients with Graves' disease: a cross-sectional survey

Pradella-Hallinan, Márcia; Pereira, José Carlos; Martins, João Roberto Maciel

doi:10.6061/clinics/2020/e2140

Cited by 3 publications

(4 citation statements)

References 26 publications

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“…Additionally, patients who had hyperthyroidism before their hypothyroidism, which can commonly occur in autoimmune processes such as Hashimoto thyroiditis, were considerably more likely to have RLS symptoms compared with patients who did not have hyperthyroidism before hypothyroidism. Pradella-Hallinan et al ( 24 ) showed that patients with RLS and subsequent Graves disease had worsening of their RLS symptoms during the hyperthyroid state. Several patients in that study had new-onset RLS after Graves disease developed.…”

Section: Restless Legs Syndromementioning

confidence: 99%

Thyroid Dysfunction and Sleep Disorders

Green

Bernet²,

Cheung³

2021

Front. Endocrinol.

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Thyroid disorders and sleep disorders are common problems in the general population that can affect people of all ages, backgrounds, and sexes, but little is known about their clinical associations. We reviewed the literature assessing the associations between thyroid disease and sleep disorders and noted that hyperthyroidism and hypothyroidism have clinical overlap with sleep conditions such as insomnia, restless legs syndrome, and obstructive sleep apnea. These findings highlight the importance of identifying and managing thyroid dysfunction for patients with these common sleep disorders. Additional research is needed to further understand how thyroid dysfunction affects sleep physiology.

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Section: Restless Legs Syndromementioning

confidence: 99%

Thyroid Dysfunction and Sleep Disorders

Green

Bernet²,

Cheung³

2021

Front. Endocrinol.

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“…Some reviews suggest checking for thyroid dysfunctions when suspecting secondary RLS; however, studies supporting the description are lacking [ 7 , 8 , 10 ]. A study from Brazil revealed that 20% of patients with GD, who did not have RLS symptoms prior to GD, developed definite RLS or RLS-like symptoms, that lacked the definite RLS circadian characteristics during GD episodes [ 11 ]. Moreover, at least 70% of the patients reported that the RLS symptoms resolved when they turned euthyroid [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…A study from Brazil revealed that 20% of patients with GD, who did not have RLS symptoms prior to GD, developed definite RLS or RLS-like symptoms, that lacked the definite RLS circadian characteristics during GD episodes [ 11 ]. Moreover, at least 70% of the patients reported that the RLS symptoms resolved when they turned euthyroid [ 11 ]. In our case, the symptoms fully resolved once methimazole administration began and GD remitted, which implied that GD caused the symptoms.…”

Section: Discussionmentioning

confidence: 99%

A Case Report of Grave’s Disease Presenting With an Episode of Restless Legs Syndrome

Miyaue,

Isono

2024

Cureus

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This case report explores a rare presentation of restless legs syndrome (RLS) in a 59-year-old female with a history of Graves' disease (GD), highlighting the diagnostic challenges and the importance of considering thyroid dysfunctions in RLS. The patient, previously diagnosed and treated for GD, presented with acute nocturnal discomfort in her lower limbs, along with symptoms of fatigue, weight loss, and palpitations. Physical examinations and thyroid function tests indicated a recurrence of GD. Her RLS symptoms notably resolved following the treatment of GD with methimazole, pointing towards secondary RLS induced by GD. This case emphasizes the necessity of a comprehensive diagnostic approach in RLS, particularly in differentiating it from mimicking conditions including leg cramps, arthritis, peripheral neuropathy, and drug-induced akathisia, and identifying underlying etiologies like thyroid dysfunctions. The resolution of RLS symptoms after GD treatment underlines the potential link between thyroid dysfunctions, iron metabolism, and the dopaminergic system in RLS pathophysiology.

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“…Researchers from Sao Paulo, on the other hand, assessed the prevalence of RLS among patients with hyperthyroidism in the course of Graves’ disease. They found that 11.1% of patients with this disease exhibited RLS symptoms secondary to it [ 19 ]. In the context of the association between RLS and thyroid disease, the question of the autoimmune basis of thyroid disease is quite often raised.…”

Section: Discussionmentioning

confidence: 99%

Is Restless Legs Syndrome De Facto Thyroid Disease?

et al. 2022

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While a primary role in the pathogenesis of restless legs syndrome (RLS) has been attributed to dysfunction of the dopaminergic system and impaired iron metabolism (particularly in the central nervous system), it has been hypothesized that an imbalance between thyroid hormones and dopaminergic activity may be the starting point for all aspects of RLS. Although this hypothesis was proposed more than a decade ago, it has not yet been verified beyond doubt. The main aim of this study is to compare the prevalence of RLS in a population of patients with the most common thyroid gland diseases with a population of individuals with a healthy thyroid gland. The study included 237 participants divided into smaller groups according to the thyroid disease concerning them. Each participant had a laboratory diagnosis, an ultrasound scan and an assessment of the fulfilment of RLS criteria according to the International Restless Legs Syndrome Study Group (IRLSSG) criteria. The results obtained were subjected to statistical analysis. RLS is significantly more common in patients with known thyroid disease; Hashimoto’s disease, among others, manifests a 2.56× higher risk of a positive diagnosis for RLS than the general population. The association of RLS with thyroid disease is notable, although it is difficult to conclude unequivocally that there is a cause-and-effect relationship between the two. Further investigation into a potentially autoimmune cause of restless legs syndrome should be considered.

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Restless Legs Syndrome, and symptoms of Restless Syndrome in patients with Graves' disease: a cross-sectional survey

Cited by 3 publications

References 26 publications

Thyroid Dysfunction and Sleep Disorders

Thyroid Dysfunction and Sleep Disorders

A Case Report of Grave’s Disease Presenting With an Episode of Restless Legs Syndrome

Is Restless Legs Syndrome De Facto Thyroid Disease?

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