Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology

Allen, Richard P.; Picchietti, Daniel L.; Hening, Wayne A.; Trenkwalder, Claudia; Walters, Arthur S.; Montplaisi, Jacques

doi:10.1016/s1389-9457(03)00010-8

Cited by 2,646 publications

(748 citation statements)

References 102 publications

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“…1 RLS, a major contributing factor to disturbed sleep, is characterized by the urge to move the legs due to a dysesthesia often described as creepy crawly sensations, occurring during periods of repose or rest, more pronounced in the evening, and completely or nearly completely resolved with movement. 2,3 The severity and frequency of RLS can range from occasional mild symptoms to nearly constant and severely disruptive symptoms that can also involve the arms and torso and can severely impair daytime functioning and sleep. 1,4 Restless legs syndrome is a clinical diagnosis that is determined by applying the four diagnostic questions of the International Restless Legs Syndrome Study Group, 2,3 either by a face-to-face interview or a telephone interview.…”

Section: S C I E N T I F I C I N V E S T I G a T I O N Smentioning

confidence: 99%

Ethnic Differences in the Prevalence and Predictors of Restless Legs Syndrome between Hispanics of Mexican Descent and Non-Hispanic Whites in San Diego County: A Population-Based Study

Sawanyawisuth

Palinkas

Ancoli‐Israel

et al. 2013

Journal of Clinical Sleep Medicine

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Section: S C I E N T I F I C I N V E S T I G a T I O N Smentioning

confidence: 99%

Ethnic Differences in the Prevalence and Predictors of Restless Legs Syndrome between Hispanics of Mexican Descent and Non-Hispanic Whites in San Diego County: A Population-Based Study

Sawanyawisuth

Palinkas

Ancoli‐Israel

et al. 2013

Journal of Clinical Sleep Medicine

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“…Restless legs syndrome (RLS) is a relatively frequent and underdiagnosed sleep-related movement disorder 1 . The four criteria for considering this diagnosis include: an urge to move the legs (usually accompanied our caused by uncomfortable leg sensations); temporary relief with movement; onset or worsening of symptoms during rest; and worsening or onset of symptoms at evening and/or at night.…”

mentioning

confidence: 99%

Restless legs syndrome and multiple sclerosis: a Brazilian multicenter study and meta-analysis of the literature

Fragoso

Finkelsztejn

Gomes

et al. 2011

Arq. Neuro-Psiquiatr.

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Objective: The increased prevalence of restless legs syndrome (RLS) in multiple sclerosis (MS) has recently been the subject of a few papers. The present study investigated the prevalence of RLS symptoms in MS patients and in controls in four Brazilian cities. Additionally, a systematic review and meta-analysis of the literature was carried out on the subject of RLS-MS. Method: MS patients and controls were investigated regarding the presence of the four typical symptoms of RLS. A questionnaire assessing RLS severity was also used for patients and controls presenting the four RLS symptoms criteria. The systematic review and meta-analysis on the subject were carried out according to the strict international criteria. Results: In the present report, the RLS-MS association was confirmed as being more than fortuitous in Brazilian MS patients, in a multicenter casecontrol study. MS patients also presented RLS symptoms of greater severity than did the control population. A systematic review and meta-analysis of the literature showed that MS patients had a fourfold higher chance of presenting RLS than did the controls. Conclusion: Although underlying mechanisms to explain the association RLS-MS are still a matter of discussion, there is a clear association of these two neurological conditions. Key words: multiple sclerosis, restless legs syndrome, meta-analysis.Síndrome das pernas inquietas e esclerose múltipla: um estudo brasileiro multicên trico e metanálise da literatura RESUMO Objetivo: A maior prevalência de síndrome das pernas inquietas (SPI) em esclerose múltipla (EM) foi recentemente assunto de algumas publicações. O presente trabalho investigou a prevalência de sintomas de SPI em pacientes com EM e em controles em quatro cidades brasileiras. Além disto, uma revisão sistemática da literatura e metanálise dos dados foi feita considerando o tema SPI-EM. Método: Pacientes com EM e controles foram investigados com relação aos quarto sintomas típicos de SPI. Um questionário avaliando a intensidade da SPI também foi utilizado para pacientes e controles que apresentassem os quatro sintomas para critério diagnóstico de SPI. A revisão sistemática e meta-análise do tema foram realizadas de acordo com os rígidos critérios internacionais. Resultados: No presente estudo, a associação de SPI-EM foi confirmada como sendo mais que coincidência nos pacientes brasileiros com EM, através do estudo caso-controle multicêntrico. Os pacientes com EM também apresentaram maior gravidade dos sintomas de SPI que os controles. A revisão sistemática e metanálise da literatura mostraram que os pacientes com EM tiveram quatro vezes mais chance de apresentar SPI do que controles. Conclusão: Embora os mecanismos envolvidos na associação SPI-EM ainda sejam motivo de discussão, existe uma clara associação entre estas duas condições neurológicas. Palavras-chave: esclerose múltipla, síndrome das pernas inquietas, metanálise. Correspondence Yára Dadalti Fragoso

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“…His symptoms were relieved by mobilization and met the RLS diagnostic criteria 12. His IRLS score was 11.…”

Section: Report Of Casesmentioning

confidence: 94%

Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology

Cited by 2,646 publications

References 102 publications

Ethnic Differences in the Prevalence and Predictors of Restless Legs Syndrome between Hispanics of Mexican Descent and Non-Hispanic Whites in San Diego County: A Population-Based Study

Ethnic Differences in the Prevalence and Predictors of Restless Legs Syndrome between Hispanics of Mexican Descent and Non-Hispanic Whites in San Diego County: A Population-Based Study

Restless legs syndrome and multiple sclerosis: a Brazilian multicenter study and meta-analysis of the literature

Acupuncture point injection markedly improved sensory symptoms and motor signs in 2 patients with restless legs syndrome

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