Restless legs syndrome in hemodialysis patients

Rafie, Shahram; Jafari, Majid; Azizi, Mostafa; Bahadoram, Mohammad; Jafari, Shima

doi:10.4103/1319-2442.178553

Cited by 12 publications

(10 citation statements)

References 2 publications

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“…In contrast to some studies [4, 8–10], we found no significant association between diabetes mellitus type 2 and RLS among ESRD patients. It is not clear whether diabetes mellitus itself or diabetic peripheral neuropathy is the dominant risk factor [33].…”

Section: Discussioncontrasting

confidence: 99%

“…Our result reveals that RLS is more common in female ESRD patients (OR = 2.729, p = 0.032), similar to some other studies [5, 8, 24]. In general population studies, RLS is consistently more common in females [23, 25], although one German study found this was explained by previous pregnancies, such that null-parous women had similar RLS rates as men [25, 26].…”

Section: Discussionsupporting

confidence: 89%

“…Furthermore, the symptoms of RLS have improved with high-dose iron dextran therapy among the ESRD patients, which also suggested that IDA could induce RLS [36] . Other studies showed no relationship between IDA and RLS in ESRD patients [5, 8, 12].…”

Section: Discussionmentioning

confidence: 87%

“…RLS in ESRD patients has been variably reported to be associated with female gender [5, 6], duration of dialysis [4, 7], diabetes mellitus [4, 8–10], iron deficiency anemia [4, 10, 11], parathyroid hormone [12], increased body mass index (BMI) [13], and increased homocysteine [14]. However, results are very inconsistent.…”

Section: Introductionmentioning

confidence: 99%

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Restless legs syndrome in end stage renal disease patients undergoing hemodialysis

et al. 2019

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Background The prevalence of Restless legs syndrome (RLS) in End Stage Renal Disease (ESRD) patients is higher than that in the general population. However, the associations of RLS within the ESRD population are inconsistent and RLS is usually neglected in dialysis centers, although it impairs the life quality among ESRD patients. We aim to investigate the prevalence of RLS in patients with ESRD undergoing maintenance hemodialysis and evaluate the risk factors of developing RLS and the effect of RLS on quality of life among ESRD patients. Methods ESRD patients undergoing maintenance hemodialysis in Shanghai General Hospital dialysis unit from July 2016 to October 2016 were enrolled in the study. RLS was diagnosed according to the criteria of the International Restless Legs Syndrome Study Group (IRLSSG). IRLSSG Severity Scale was used to evaluate the severity of RLS. Pittsburgh Sleep Quality Index (PSQI) was used to evaluate sleep quality, and Hospital Anxiety and Depression Scale (HADS) was used to estimate anxiety and depression. Serologic and historic variables were analyzed to determine predictors of RLS in the ESRD population. Results A total of 137 ESRD patients were enrolled. The prevalence of RLS among the ESRD patients was 20.44%. The risk of RLS was increased significantly in females (OR = 2.729, p = 0.032) and daily alcohol drinkers (OR = 4.716, p = 0.022). RLS increased the risks of sleep disorders (25/28, 89.3% vs 73/109, 67.0%, p = 0.02) and sedative hypnotics intake (7/28, 25.0% vs 10/109, 9.2%, p = 0.047) and impaired the sleep quality (7/109 vs 11/28, p = 0.001) according to PSQI sum scores. Conclusion A high RLS prevalence among the ESRD patients undergoing hemodialysis was confirmed. ESRD patients who are women and drinking alcohol have a higher risk of RLS. The sleep quality was significantly impaired and sleeping medication use was more common among the ESRD patients with RLS.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

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Restless legs syndrome in end stage renal disease patients undergoing hemodialysis

et al. 2019

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“…Chronic kidney disease, diabetes, and oxidative stress are associated with uremic RLS [ 18 ]. Some studies say polyneuropathy is the highest risk factor of RLS in diabetic patients as it affects catecholaminergic systems by reducing the dopaminergic content, thus affecting the midbrain and striatum, which is crucial for RLS [ 7 ].…”

Section: Reviewmentioning

confidence: 99%

Restless Leg Syndrome in the Setting of Patients With End-Stage Renal Disease on Hemodialysis: A Literature Review

Kambampati¹,

Wasim²,

Kukkar³

et al. 2020

Cureus

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Restless Leg Syndrome (RLS), or Willis-Ekbom disease (WED), is an irresistible urge to move the legs, predominantly while resting, sitting, or sleeping, which disrupts sleep and impairs quality of life. RLS can occur secondary to uremia in chronic kidney disease (CKD) patients due to inadequate hemodialysis. Early diagnosis is essential to prevent muscular atrophy and to improve the quality of life of RLS patients, especially those with end-stage renal disease (ESRD). Cardiac mortality high in uremic RLS patients due to associated discomfort and lowering the duration of hemodialysis treatment. This review focuses on and discusses the diagnosis, treatment, and associated comorbid conditions of uremic RLS. Though the exact pathophysiology is unknown, altered transferrin expression in the choroid plexus, increased glutamate levels in the thalamus, decreased opioid receptors, dopamine system dysfunction, calcium/phosphate imbalance, and single nucleotide polymorphisms in the BTBD9 and MEIS1 genes are a few nonconfirmatory pathophysiological concepts for uremic RLS. Nonpharmacological options include lowering the temperature of dialysate by 1 degree C and home-based therapies like massages, warm/cold baths, and aerobic exercises. Pharmacological therapy like dopamine agonists ropinirole and pramipexole reduces the symptoms effectively. However, surgical options like parathyroidectomy and renal transplantation are stated as the best treatment options in patients suffering from uremic RLS.

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Restless legs syndrome in maintenance hemodialysis patients: an epidemiologic survey in Hefei

et al. 2017

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Restless legs syndrome in hemodialysis patients

Cited by 12 publications

References 2 publications

Restless legs syndrome in end stage renal disease patients undergoing hemodialysis

Restless legs syndrome in end stage renal disease patients undergoing hemodialysis

Restless Leg Syndrome in the Setting of Patients With End-Stage Renal Disease on Hemodialysis: A Literature Review

Restless legs syndrome in maintenance hemodialysis patients: an epidemiologic survey in Hefei

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