Restless Legs Syndrome in Patients with Irritable Bowel Syndrome: Response to Small Intestinal Bacterial Overgrowth Therapy

Weinstock, Leonard B.; Fern, Steve E.; Duntley, Stephen P.

doi:10.1007/s10620-007-0021-0

Cited by 47 publications

(58 citation statements)

References 40 publications

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“…SIBO proved to be more prevalent in patients with IBS patients [136][137][138] , and its eradication with antibiotics relieved the symptoms of IBS [139][140][141][142] . The presence of SIBO might be associated with abnormalities in small intestinal motor function.…”

Section: Altered Intestinal Microbiotamentioning

confidence: 99%

Irritable bowel syndrome: Emerging paradigm in pathophysiology

Lee

Park

2014

WJG

136

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Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders, characterized by abdominal pain, bloating, and changes in bowel habits. These symptoms cannot be explained by structural abnormalities and there is no specific laboratory test or biomarker for IBS. Therefore, IBS is classified as a functional disorder with diagnosis dependent on the history taking about manifested symptoms and careful physical examination. Although a great deal of research has been carried out in this area, the pathophysiology of IBS is complex and not completely understood. Multiple factors are thought to contribute to the symptoms in IBS patients; altered gastrointestinal motility, visceral hypersensitivity, and the brain-gut interaction are important classical concepts in IBS pathophysiology. New areas of research in this arena include inflammation, postinfectious low-grade inflammation, genetic and immunologic factors, an altered microbiota, dietary factors, and enteroendocrine cells. These emerging studies have not shown consistent results, provoking controversy in the IBS field. However, certain lines of evidence suggest that these mechanisms are important at least a subset of IBS patients, confirming that IBS symptoms cannot be explained by a single etiological mechanism. Therefore, it is important to keep in mind that IBS requires a more holistic approach to determining effective treatment and understanding the underlying mechanisms.

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Section: Altered Intestinal Microbiotamentioning

confidence: 99%

Irritable bowel syndrome: Emerging paradigm in pathophysiology

Lee

Park

2014

WJG

136

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“…38 SIBO by itself can increase intestinal permeability 39 ; SIBO is associated with fibromyalgia 40 and restless legs syndrome (RLS), 41 with treatment of SIBO producing clinically significant improvement in a small group of patients with RLS. 41 The CNS effects of elevated gut-derived LPS or peptidoglycan exposure might contribute to the pathogenesis of these disorders.…”

mentioning

confidence: 99%

The Gut Microbiome and the Brain

Galland

2014

Journal of Medicinal Food

553

390

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“…The occurrence of SIBO has been associated with abnormalities in small intestinal motor function (73) and its eradication with symptomatic relief (68,69,72,(74)(75)(76)(77). These striking results have been the target of much criticism on several grounds (78)(79)(80)(81)(82)(83)(84)(85).…”

Section: Qualitative or Quantitative Changes In The Enteric Flora (Mimentioning

confidence: 99%

Irritable bowel syndrome; update on pathophysiology and management

Quigley¹,

Craig²

2012

Turk J Gastroenterol

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The functional gastrointestinal disorders (FGID) are symptom-based disorders that cannot be currently explained by definable structural or biochemical causes (1). These disorders are common: the presence of at least one functional GI disorder was identified in 70% of participants in a large US householder survey (2). An associated co-morbid psychiatric condition such as anxiety, mood or panic disorder is seen in up to 60% of those attending gastroenterology outpatient clinics with a functional compliant (3). Functional GI disorders are associated with significant impairment of quality of

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Restless Legs Syndrome in Patients with Irritable Bowel Syndrome: Response to Small Intestinal Bacterial Overgrowth Therapy

Abstract: This study suggests that SIBO associated with IBS may be a factor in some RLS patients and SIBO therapy provides long-term RLS improvement.

Cited by 47 publications

References 40 publications

Irritable bowel syndrome: Emerging paradigm in pathophysiology

Irritable bowel syndrome: Emerging paradigm in pathophysiology

The Gut Microbiome and the Brain

Irritable bowel syndrome; update on pathophysiology and management

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