Restorable, high-strength poly(N-isopropylacrylamide) hydrogels constructed through chitosan-based dual macro-cross-linkers with rapid response to temperature jumps

M., X.; Li, R.; Ren, Jingjing; Lv, Xiang; Zhao, Xianwei; Ji, Qianqian; Xia, Yanzhi

doi:10.1039/c7ra10148a

Cited by 19 publications

(12 citation statements)

References 24 publications

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“…Normalized swelling and deswelling rates of the 10 °C sample were calculated by dividing the volume change rates obtained from Figure 3d by the swollen hydrogel volume, then compared to those calculated from some representative literature focusing on fast stimuli-responsive PNIPAM hydrogels (Figure 3e). [46][47][48][49][50][51][52][53][54][55][56][57][58][59] In this comparison, it is readily observed that both normalized swelling and deswelling rates in this work are about an order of magnitude higher than what has been reported. Comparing to the few works measuring both the deswelling rate and Young's modulus of their PNIPAM hydrogels, this work demonstrates a record-breaking order of magnitude improvement in both properties without compromise (Figure 3f).…”

Section: Resultsmentioning

confidence: 66%

Tunable Sponge‐Like Hierarchically Porous Hydrogels with Simultaneously Enhanced Diffusivity and Mechanical Properties

Alsaid

et al. 2021

Advanced Materials

118

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Crosslinked polymers and gels are important in soft robotics, solar vapor generation, energy storage, drug delivery, catalysis, and biosensing. However, their attractive mass transport and volume‐changing abilities are diffusion‐limited, requiring miniaturization to avoid slow response. Typical approaches to improving diffusion in hydrogels sacrifice mechanical properties by increasing porosity or limit the total volumetric flux by directionally confining the pores. Despite tremendous efforts, simultaneous enhancement of diffusion and mechanical properties remains a long‐standing challenge hindering broader practical applications of hydrogels. In this work, cononsolvency photopolymerization is developed as a universal approach to overcome this swelling–mechanical property trade‐off. The as‐synthesized poly(N‐isopropylacrylamide) hydrogel, as an exemplary system, presents a unique open porous network with continuous microchannels, leading to record‐high volumetric (de)swelling speeds, almost an order of magnitude higher than reported previously. This swelling enhancement comes with a simultaneous improvement in Young's modulus and toughness over conventional hydrogels fabricated in pure solvents. The resulting fast mass transport enables in‐air operation of the hydrogel via rapid water replenishment and ultrafast actuation. The method is compatible with 3D printing. The generalizability is demonstrated by extending the technique to poly(N‐tertbutylacrylamide‐co‐polyacrylamide) and polyacrylamide hydrogels, non‐temperature‐responsive polymer systems, validating the present hypothesis that cononsolvency is a generic phenomenon driven by competitive adsorption.

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Section: Resultsmentioning

confidence: 66%

Tunable Sponge‐Like Hierarchically Porous Hydrogels with Simultaneously Enhanced Diffusivity and Mechanical Properties

Alsaid

et al. 2021

Advanced Materials

118

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“…Thermoresponsive Cs-g-PNIPAAm hydrogels are typically synthesized via ceric ammonium nitrate [49] or 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide [50]. However, grafting can be problematic with a narrow distribution of molecular weight on the side chains.…”

Section: Discussionmentioning

confidence: 99%

Synthesis and Evaluation of a Thermoresponsive Degradable Chitosan-Grafted PNIPAAm Hydrogel as a “Smart” Gene Delivery System

et al. 2020

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Thermoresponsive hydrogels demonstrate tremendous potential as sustained drug delivery systems. However, progress has been limited as formulation of a stable biodegradable thermosensitive hydrogel remains a significant challenge. In this study, free radical polymerization was exploited to formulate a biodegradable thermosensitive hydrogel characterized by sustained drug release. Highly deacetylated chitosan and N-isopropylacrylamide with distinctive physical properties were employed to achieve a stable, hydrogel network at body temperature. The percentage of chitosan was altered within the copolymer formulations and the subsequent physical properties were characterized using 1H-NMR, FTIR, and TGA. Viscoelastic, swelling, and degradation properties were also interrogated. The thermoresponsive hydrogels were loaded with RALA/pEGFP-N1 nanoparticles and release was examined. There was sustained release of nanoparticles over three weeks and, more importantly, the nucleic acid cargo remained functional and this was confirmed by successful transfection of the NCTC-929 fibroblast cell line. This tailored thermoresponsive hydrogel offers an option for sustained delivery of macromolecules over a prolonged considerable period.

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“…; limiting the preparation technique’s usage [ 129 ]. Several investigations have been reported e.g., alginate/ N -isopropylacrylamide (NIPAM) hydrogel [ 131 ], PNIPAM/poly(sodium acrylate) hydrogel [ 132 ], methacryloylchitosan/PNIPAM hydrogel [ 133 ], polyacrylamide/sodium alginate IPN hydrogel [ 134 ], etc. ; based on ionic interaction of PNIPAM-based hydrogel systems for improving stiffness, cell viability, and mechanical integrity of the hydrogel system.…”

Section: Preparation Of Pnipam-based Hydrogel Systemsmentioning

confidence: 99%

Poly(N-isopropylacrylamide)-Based Hydrogels for Biomedical Applications: A Review of the State-of-the-Art

Ansari

Rajendran

Mohanto

et al. 2022

Gels

113

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A prominent research topic in contemporary advanced functional materials science is the production of smart materials based on polymers that may independently adjust their physical and/or chemical characteristics when subjected to external stimuli. Smart hydrogels based on poly(N-isopropylacrylamide) (PNIPAM) demonstrate distinct thermoresponsive features close to a lower critical solution temperature (LCST) that enhance their capability in various biomedical applications such as drug delivery, tissue engineering, and wound dressings. Nevertheless, they have intrinsic shortcomings such as poor mechanical properties, limited loading capacity of actives, and poor biodegradability. Formulation of PNIPAM with diverse functional constituents to develop hydrogel composites is an efficient scheme to overcome these defects, which can significantly help for practicable application. This review reports on the latest developments in functional PNIPAM-based smart hydrogels for various biomedical applications. The first section describes the properties of PNIPAM-based hydrogels, followed by potential applications in diverse fields. Ultimately, this review summarizes the challenges and opportunities in this emerging area of research and development concerning this fascinating polymer-based system deep-rooted in chemistry and material science.

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Restorable, high-strength poly(N-isopropylacrylamide) hydrogels constructed through chitosan-based dual macro-cross-linkers with rapid response to temperature jumps

Abstract: Thermo-responsive, high mechanical poly(N-isopropylacrylamide) hydrogels with excellent recoverability and rapid response rate are constructed on chitosan-based dual macro-cross-linkers.

Cited by 19 publications

References 24 publications

Tunable Sponge‐Like Hierarchically Porous Hydrogels with Simultaneously Enhanced Diffusivity and Mechanical Properties

Tunable Sponge‐Like Hierarchically Porous Hydrogels with Simultaneously Enhanced Diffusivity and Mechanical Properties

Synthesis and Evaluation of a Thermoresponsive Degradable Chitosan-Grafted PNIPAAm Hydrogel as a “Smart” Gene Delivery System

Poly(N-isopropylacrylamide)-Based Hydrogels for Biomedical Applications: A Review of the State-of-the-Art

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