Restoration of a peri-implant defect by platelet-rich fibrin

Lee, Jun Young; Kim, Seong‐Gon; Kim, Jwa-Young; Lee, Yong-Chan; Choi, Je‐Yong; Dragos, Rosca; Rotaru, Horaţiu

doi:10.1016/j.tripleo.2011.03.043

Cited by 54 publications

(45 citation statements)

References 17 publications

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“…The findings of this study were in agreement with the results reported by Anitua et al Using a similar approach, these authors reported a 51% BIC when implants were coated with PRGF compared to the 22% BIC of the control group after 8 weeks of healing time (5-8). Our results also confirm the data presented by Lee et al who have reported that the mean new bone formation was 29% in the experimental group and 11% in the control group with a BIC of 39% vs 17% (16). Furthermore, our results support the findings by Fontana et al and those of another study where PRP improved BIC for roughened implants inserted in rat tibias (11,15).…”

Section: Discussionsupporting

confidence: 93%

Positive effect of platelet rich fibrin on osseointegration

Öncü¹,

Bayram²,

Kantarcı³

et al. 2016

Med Oral

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BackgroundLeukocyte-platelet rich fibrin (L-PRF) is a second generation platelet concentrate clinically used to accelerate tissue healing and bone regeneration. Achieving reduced implant osseointegration time could provide immediate or early loading of implants. The aim of this study was to evaluate the L-PRF-induced osseointegration and bone-implant contact (BIC) in an experimental animal model.Material and MethodsTwelve 4-month-old New Zealand white rabbits were used. Following general anesthesia, 3-5 mL of blood was obtained from the central artery in rabbit ear and L-PRF was prepared. Two implant cavities (5 mm long and 3 mm in diameter) were created in each tibia with a total of four cavities in each animal. Two of these cavities were selected and covered with PRF (test group). The remaining L-PRF was used to soak the implants placed into the L-PRF covered sockets. Other cavities were left as controls. In total, 48 implants were placed. Animals were sacrificed after two, three, or four weeks. Histological samples were obtained and peri-implant tissues were histomorphometrically evaluated for bone-to-implant contact and new bone formation.ResultsHistomorphometric analyses of the defects revealed that the L-PRF was detectable up to the second week. Application of L-PRF increased the rate and amount of new bone formation in the experimental group compared to the control group. Bone-to-implant contact was enhanced when the surface was pre-wetted with L-PRF (p<0.01).ConclusionsThe results of this study demonstrated that L-PRF application may increases amount and rate of new bone formation during the early healing period and provides a faster osseointegration around implants. Key words:Dental implants, platelet rich fibrin, osseointegration, bone regeneration, matrix for growth factors.

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Section: Discussionsupporting

confidence: 93%

Positive effect of platelet rich fibrin on osseointegration

Öncü¹,

Bayram²,

Kantarcı³

et al. 2016

Med Oral

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“…All the cases in PRF group showed complete trabecular bone formation by the end of 6 months. Similar results were obtained by Lee J W et al (2012) 14 in their animal study which showed that more amount of bone regeneration occurred in a peri implant defect filled with PRF than unfilled defects.…”

Section: Discussion:-supporting

confidence: 88%

Radiological Assessment of Healing in Periapical Defects Treated With Platelet Rich Plasma and Platelet Rich Fibrin Along With Alloplastic Material- A Comparative Study.

RaoI¹,

Sowjanya²,

Bhushan³

et al. 2018

IJAR

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“…These growth factors have been identified as key players in the process of tissue remodeling. Currently, PRF is widely used in the treatment of cartilage defects 9) , soft tissue defects 10,13) , and bone defects 11,12) . However, its poor mechanical strength has limited its application.…”

Section: Introductionmentioning

confidence: 99%

New Biodegradable Implant Material Containing Hydrogel with Growth Factors of Lyophilized PRF in Combination with an nHA/PLGA Scaffold

Zheng

Wang

Qin

et al. 2015

J. Hard Tissue Biology.

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The temperature-sensitive triblock copolymer poly-(D, L-lactic acid-co-glycolic acid) (PLGA)-polyethylene glycol (PEG)-PLGA (PLGA-PEG-PLGA) is an FDA-approved material that has the ability to provide a sustained release of drugs and/or proteins. Platelet-rich fibrin(PRF)is second generation platelet concentration that contains growth factors such as transforming growth factor-1 (TGF-1), platelet derived growth factor-AB (PDGF-AB), and insulin-like growth factor-I (IGF-I). These growth factors affect the migration and proliferation of diverse cell types, including endothelial cells, smooth muscle cells, and osteoblast-like cells. This study sought to combine the hydrogel into scaffolds in order to serve as a sustained release system for PRF-derived growth factors. Poly (lactic-co-glycolic) acid (PLGA) and nano-hydroxyapatite (nHA) were used to prepare the hydrogel-containing scaffolds with the PRF-derived growth factors. We then investigated the effects of the hydrogel on modulating the activity of osteoblasts in vitro. We indicated that the hydrogel (Gel) was well-distributed in the inner surface of scaffolds, which themselves exhibited relatively interconnected pores with uniform sizes. The addition of the hydrogel didn't affect their inherently high porosity. In vitro release tests indicated that the system containing nHA/PLGA/Gel/PRF provided for a slow and sustained release of PRF-derived growth factors. The results from our in vitro studies indicated that the MG63 cells cultured with both scaffold media extracts did not appear to have cytotoxic responses, and the nHA/PLGA/Gel/PRF system could improve the adhesion and proliferation of MG63 cells when compared to controls (p < 0.05). This in vitro evaluation suggests that the hydrogel-scaffold system is suitable as a model for bone tissue engineering, and that it allows for the sustained release of growth factors to improve bone reconstruction.

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Restoration of a peri-implant defect by platelet-rich fibrin

Cited by 54 publications

References 17 publications

Positive effect of platelet rich fibrin on osseointegration

Positive effect of platelet rich fibrin on osseointegration

Radiological Assessment of Healing in Periapical Defects Treated With Platelet Rich Plasma and Platelet Rich Fibrin Along With Alloplastic Material- A Comparative Study.

New Biodegradable Implant Material Containing Hydrogel with Growth Factors of Lyophilized PRF in Combination with an nHA/PLGA Scaffold

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