Restoration of segmental bone defects in rabbit radius by biodegradable capsules containing recombinant human bone morphogenetic protein-2

Mori, Masahiro; Isobe, Masatsugu; Yamazaki, Yasuharu; Ishihara, Kazuhíko; Nakabayashi, Nobuo

doi:10.1002/(sici)1097-4636(200005)50:2<191::aid-jbm14>3.0.co;2-0

Cited by 38 publications

(22 citation statements)

References 23 publications

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“…Although mimicking the geometric architecture of bone in a synthetic scaffold has been shown to promote favorable cellular activity, the overall capacity for a scaffold to direct cell behavior can be substantially improved through the controlled delivery of biospecific cues. 49,[217][218][219][220][221] Administration of growth factors and other bioactive molecules to promote bone formation and repair has achieved promising results in several preclinical and clinical models. [222][223][224][225][226][227] A variety of administration methods have been investigated including: bolus injection, surface adsorbed protein release, osmotic pumps, and controlled release from biodegradable scaffolds.…”

Section: Localized Bioactive Molecule and Drug Delivery In Bone Repairmentioning

confidence: 99%

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Porter

Ruckh

Popat

2009

Biotechnology Progress

685

499

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Critical‐sized defects in bone, whether induced by primary tumor resection, trauma, or selective surgery have in many cases presented insurmountable challenges to the current gold standard treatment for bone repair. The primary purpose of a tissue‐engineered scaffold is to use engineering principles to incite and promote the natural healing process of bone which does not occur in critical‐sized defects. A synthetic bone scaffold must be biocompatible, biodegradable to allow native tissue integration, and mimic the multidimensional hierarchical structure of native bone. In addition to being physically and chemically biomimetic, an ideal scaffold is capable of eluting bioactive molecules (e.g., BMPs, TGF‐βs, etc., to accelerate extracellular matrix production and tissue integration) or drugs (e.g., antibiotics, cisplatin, etc., to prevent undesired biological response such as sepsis or cancer recurrence) in a temporally and spatially controlled manner. Various biomaterials including ceramics, metals, polymers, and composites have been investigated for their potential as bone scaffold materials. However, due to their tunable physiochemical properties, biocompatibility, and controllable biodegradability, polymers have emerged as the principal material in bone tissue engineering. This article briefly reviews the physiological and anatomical characteristics of native bone, describes key technologies in mimicking the physical and chemical environment of bone using synthetic materials, and provides an overview of local drug delivery as it pertains to bone tissue engineering is included. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2009

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Section: Localized Bioactive Molecule and Drug Delivery In Bone Repairmentioning

confidence: 99%

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Porter

Ruckh

Popat

2009

Biotechnology Progress

685

499

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“…5 Polylactideco-glycolide (PLGA) has been approved by the US Food and Drug Administration for certain human clinical applications and has been extensively studied for drug delivery. [6][7][8] As a copolymer of polylactic acid and polyglycolic acid, PLGA is a biodegradable polyester, the variable molecular weight and composition of which can be rationally designed to control the release kinetics of encapsulated therapeutic agents. The incorporation of osteoconductive nano-hydroxyapatite into PLGA can improve the mechanical properties and moderate the degradation rate of the scaffold.…”

Section: Nanomaterials For Bone Regenerationmentioning

confidence: 99%

Nanomaterials enhance osteogenic differentiation of human mesenchymal stem cells similar to a short peptide of BMP-7

Lock¹,

Liu²

2011

IJN

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Background: Nanomaterials have unique advantages in controlling stem cell function due to their biomimetic characteristics and special biological and mechanical properties. Controlling adhesion and differentiation of stem cells is critical for tissue regeneration. Methods: This in vitro study investigated the effects of nano-hydroxyapatite, nano-hydroxyapatitepolylactide-co-glycolide (PLGA) composites, and a bone morphogenetic protein (BMP-7)-derived short peptide (DIF-7c) on osteogenic differentiation of human mesenchymal stem cells (MSC). The peptide was chemically functionalized onto nano-hydroxyapatite, incorporated into a nanophase hydroxyapatite-PLGA composite or PLGA control, or directly injected into culture media. Results: Unlike the PLGA control, the nano-hydroxyapatite-PLGA composites promoted adhesion of human MSC. Importantly, nano-hydroxyapatite and nano-hydroxyapatite-PLGA composites promoted osteogenic differentiation of human MSCs, comparable with direct injection of the DIF-7c peptide into culture media. Conclusion: Nano-hydroxyapatite and nano-hydroxyapatite-PLGA composites provide a promising alternative in directing the adhesion and differentiation of human MSC. These nanocomposites should be studied further to clarify their effects on MSC functions and bone remodeling in vivo, eventually translating to clinical applications.

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“…10 Previous studies have shown the ability of BMPs to induce bone formation in a variety of models with many clinical applications in orthopedics and in oral and maxillofacial/dental areas. 11,12 Demineralized freezedried bone allografts (DFDBA), which are known to contain BMPs, have been used and tested extensively for periodontal regeneration. 13 Histologic evidence of enhanced formation of bone, cementum, and connective tissue attachment has been demonstrated in human periodontal defects.…”

Section: Introductionmentioning

confidence: 99%

Bone inductive proteins to enhance postorthodontic stability

Hassan

Al-Hubail

Al-Fraidi

2010

The Angle Orthodontist

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Objectives: To evaluate the use of bone morphogenetic proteins to enhance postorthodontic stability in sheep and to develop a biological method of postorthodontic retention. Materials and Methods: First incisors were extracted in four mature and healthy sheep, and the second incisors were tipped reciprocally toward the midline and then retained. Dried bone matrix was injected into the distal periodontal space of the left second incisor. The right second incisor was left as a control. Both incisors were retained in the tipped position for 4 weeks. Then, the orthodontic appliance was removed and the teeth were left without retention. Six weeks later, the animals were killed and serial sections were prepared for histologic observation. Results: Unlike the control, the experimental second incisor maintained its tipped position with minimal relapse. On the distal periodontal space of the experimental tooth, areas of focal fusion between newly formed bone and newly formed areas of hypercementosis were observed. In the distal periodontal space of the control tooth, osteoclastic activity was observed along most of the socket wall, and the periodontal space appeared narrow and compressed. This brought the tooth close to the boundary of the alveolar bone, confirming the relapse observed on that side. Conclusion: This study proposes a new method of retention in which a biologically safe osteoinductive material is used to retain the teeth via induction of points of approximation between the cementum and alveolar bone.

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Restoration of segmental bone defects in rabbit radius by biodegradable capsules containing recombinant human bone morphogenetic protein-2

Cited by 38 publications

References 23 publications

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Nanomaterials enhance osteogenic differentiation of human mesenchymal stem cells similar to a short peptide of BMP-7

Bone inductive proteins to enhance postorthodontic stability

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