Restoration of Stiffness During Fracture Healing at the Distal Radius, Using HR-pQCT and Finite Element Methods

Spanswick, Phillip; Whittier, Danielle E.; Kwong, Cory A.; Korley, Robert; Boyd, Steven K.; Schneider, Prism

doi:10.1016/j.jocd.2020.12.003

Cited by 6 publications

(3 citation statements)

References 29 publications

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“…Heyer et al [27] performed a randomised controlled trial using HR-pQCT to assess fracture healing, a modality previously shown to be viable for assessing fracture healing [32][33][34]. This study showed an unexpected detrimental effect of high-dose 25OHD supplementation on trabecular number and trabecular separation, as well as decreased compression stiffness compared to the control group.…”

Section: Discussionmentioning

confidence: 98%

Effect of Vitamin D Supplementation on Fracture Healing: A Systematic Review of Prospective Clinical Trials

ME,

2022

JSM Bone and Joint Dis

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Background: The relationship of vitamin D status with regard to its deficiency and supplementation in the setting of fracture healing has not been well established. This review aims to evaluate the efficacy of vitamin D on clinical fracture healing Methods: A systematic review of English articles using EMBASE, MEDLINE and the Cochrane Controlled Trials Register was performed. Search terms included vitamin D, cholecalciferol, colecalciferol, hydroxycholecalciferol, calcifediol, calcitriol, dihydroxycholecalciferol, ergocalciferol, dihydrotachysterol, viosterol, 1,25- hydroxyvitamin D, 25-hydroxyvitamin D, 24,25-dihyroxyvitamin D, 25 hydroxyvitamin D, lunacalcipol, vitamin D3 and fracture healing or repair. Only prospective, original trials investigating vitamin D deficiency or its supplementation on fracture related outcomes in humans were included. Results: Overall rates of delayed union in the setting of vitamin D deficiency are low. Vitamin D supplementation appears to have no effect on eventual fracture union in an adult fracture population when assessed by clinical examination and plain radiographs. Conclusions: Prospective, interventional studies of vitamin D supplementation on fracture healing are yet to demonstrate an effect on fracture healing outcome measures.

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Section: Discussionmentioning

confidence: 98%

Effect of Vitamin D Supplementation on Fracture Healing: A Systematic Review of Prospective Clinical Trials

ME,

2022

JSM Bone and Joint Dis

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“…In the wrist, it is particularly useful for distinguishing trabecular from cortical bone and for identifying cartilage. This technique is included in this section because µFE and µCT scanning, specific cases of QCT-FE, have lately been used to study distal radius fractures 20,[28][29][30] and to construct partialwrist models of carpal bones with highly detailed cartilage surfaces. 31,32 It is possible that the trend of creating hyperelastic models may eventually aid techniques such as QCT-FE to model other nonelastic features.…”

Section: Modelingmentioning

confidence: 99%

Finite Element Modeling of the Human Wrist: A Review

et al. 2023

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Background Understanding wrist biomechanics is important to appreciate and treat the wrist joint. Numerical methods, specifically, finite element method (FEM), have been used to overcome experimental methods' limitations. Due to the complexity of the wrist and difficulty in modeling, there is heterogeneity and lack of consistent methodology in the published studies, challenging our ability to incorporate information gleaned from the various studies. Questions/Purposes This study summarizes the use of FEM to study the wrist in the last decade. Methods We included studies published from 2012 to 2022 from databases: EBSCO, Research4Life, ScienceDirect, and Scopus. Twenty-two studies were included. Results FEM used to study wrist in general, pathology, and treatment include diverse topics and are difficult to compare directly. Most studies evaluate normal wrist mechanics, all modeling the bones, with fewer studies including cartilage and ligamentous structures in the model. The dynamic effect of the tendons on wrist mechanics is rarely accounted for. Conclusion Due to the complexity of wrist mechanics, the current literature remains incomplete. Considering published strategies and modeling techniques may aid in the development of more comprehensive and improved wrist model fidelity.

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“…In the same studies, the stiffness of the fractured radii, computed using µFE-analysis, increased significantly compared to baseline later during healing and continued to increase until months after cast removal [86,87]. The contribution of the lower-mineralized woven bone to the biomechanical recovery of distal radius fractures has not been quantified, and previous HR-pQCT studies are inconclusive about the differences in the stiffness of fractured distal radii during healing computed using µFE-models that either include or exclude lower-mineralized tissue [86,94]. Lower-mineralized tissue may however play a role that is not quantified when using a single series of µFE-models given the reported difference in the clinical and biomechanical perspective of fracture union.…”

Section: Distal Radius Fracture Healingmentioning

confidence: 99%

Application of high-resolution peripheral quantitative computed tomography in a clinical setting

Bevers

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Restoration of Stiffness During Fracture Healing at the Distal Radius, Using HR-pQCT and Finite Element Methods

Cited by 6 publications

References 29 publications

Effect of Vitamin D Supplementation on Fracture Healing: A Systematic Review of Prospective Clinical Trials

Effect of Vitamin D Supplementation on Fracture Healing: A Systematic Review of Prospective Clinical Trials

Finite Element Modeling of the Human Wrist: A Review

Application of high-resolution peripheral quantitative computed tomography in a clinical setting

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