Restorative Effects of Aloe Vera Gel on Alcohol Induced Hepato-Nephrocellular Dysfunction

Akinloye, Dorcas Ibukun; Ugbaja, Regina Ngozi; Dosumu, Oluwatosin Adebisi; Akamo, Adio J.; Adeyemo, A. B.

doi:10.2478/fv-2021-0001

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…Hepato/nephro-cellular dysfunction was recently reported by the Akinloye et al (2021) in which 250 mg/kg body weight of Aloe vera gel significantly lowered the serum urea, uric acid and creatinine as compared to alcohol induced toxic group. Serum albumin results were also in line with our study.…”

Section: Discussionmentioning

confidence: 94%

“…Most of the previous studies was done on Aloe vera based extract and little data reported the effect of Aloe vera based juice. ALP, AST and bilirubin are responsive biomarker implicated directly in liver tissue damage and toxicity (Akinloye et al, 2021) hepatotoxicity induced rabbits showed significantly high liver indices e.g., ALT, AST, ALP and administration of Aloe vera juice found to be effective in reducing liver enzymes in toxicity induced groups. In another study Aloe vera polysaccharides administration in aflatoxins B1 induced hepatotoxicity (Albino Rats) the serum ALT and AST reduced significantly near to normal rats group value (Cui et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the restorative activity of Aloe vera could be due to bioactive substances. These bioactives are responsible for therapeutic effects of Aloe vera juice and could account for its modulatory ability to ameliorate hepatotoxicity (Akinloye et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

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Functional potential of Aloe vera juice against CCl4 induced hepatotoxicity in animal model

et al. 2023

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The present study was designed to evaluate functional potential of Aloe vera juice against (CCl 4 induced) hepatotoxicity using animal model. Biochemical analyses including liver, renal enzymes, bone biomarkers and lipid profile were conducted after 4 weeks of oral Aloe vera juice administration. Liver enzymes, AST, ALP and total bilirubin were reduced up to 15-7%, 60-32.52% and 29-48%, respectively in Aloe vera juice treated rats i.e., 10 mL/kg and 20 mL/kg doses. Reduction in serum cholesterol (8%), LDL (12%) and triglycerides (15%) were observed. Urea was significantly reduced up to 11% which further reduced up to 30% at higher dose. Increased content of serum proteins (23-50%) and albumin (40-116%) were found at the different doses. Vitamin D was found maximum in G 4 i.e., 38.63 mg/dL as compared to lowest i.e., 5.12 mg/dL in G 2 , similarly improvement in calcium i.e., 11-22% was observed in G 3 and G 4 . The serum oxidative stress markers indicated raised superoxide dismutase (9%), glutathione (15%), catalase (9%) and reduced lipid peroxidation 78% at higher concentration of Aloe vera juice consumption. In addition, histological evaluation also depicted positive impact on hepatic and renal portfolio in all treated rats. All of the findings enlighten the potential of Aloe vera juice as a functional beverage.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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Functional potential of Aloe vera juice against CCl4 induced hepatotoxicity in animal model

et al. 2023

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Aqueous Extract of Aloe Vera Ameliorates Ethanol-Induced Liver Damage and Oxidative Stress in Balb/C Mice

Saleh,

Bedan,

Chiroma

et al. 2024

Preprint

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Purpose Exessive alcohol abuse is associated with physiological and pathological effects on the body. Aloe vera was selected because of its many beneficial qualities. Methods 25 mice were given the following treatment protocol: distilled water (normal control), 20% ethanol at 10ml/kg (negative control), 25mg/kg Aqueous extract of Aloe vera (AA) plus 20% ethanol, 50mg/kg AA plus 20% ethanol and 100mg/kg silymarin plus 20% ethanol (positive control) respectively daily for 18 days. After sacrifice, blood was collected for biochemical analysis. The liver was analysed histologically, histochemically and part was macerated to determine oxidative stress biomarkers. Results AA significantly decreased (P < .05) AST activity but it did not significantly decrease ALT activity.It significantly increased (P < .05) albumin levels. Pre-treatment with AA at 25mg/kg significantly elevated (P < .05) catalase and SOD activities. However, GSH activity was not significantly changed. AA was found to significantly reduce (P < .05) lipid peroxidation. AA significantly increased the number of hepatocytes at telophase stage relative to the ethanol-treated mice. Histological and histochemical analysis revealed normal hepatocytes with few vacuoles and fewer fat droplets in the liver parenchyma of AA treated mice compared to the ethanol group. Conclusion The results reveal that pretreatment with AA has hepatoprotective effects on ethanol-induced hepatic damage by reducing oxidative stress and preserving the histology of the hepatic tissue.

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Rejuvenating potentials of Curcuma longa on Sudan IV dye induced hepato-renal injury

Essien

Eteng

Okot-Asi

et al. 2022

CJHS

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Objectives: Sudan IV dye (S4D), has been reported to enhance the color of food products example palm oil, despite the health issues associated with these colorants. The potent antioxidant attribute of Curcuma longa facilitates its capacity to protect the kidney against deleterious attacks by free radicals. This study investigated the rejuvenating potentials of the extract of C. longa by S4D induced hepato-renal injury in rats. Material and Methods: Twenty-five female albino rats were distributed into five groups, as follows: Group 1 received distilled water and diet only, Group 2 received 10% S4D+100 mg C.L, Group 3 received 15% S4D +100 mg C.L, while Groups 4 and 5 received 200 mg and 250 mg C.L, respectively. After 3 weeks of administration of Curcuma treatment, animals were sacrificed; liver, kidney, and small intestine were collected for analyses. Aspartate and alanine aminotransferases, gamma-glutamyl transferase, glutathione-s-transferase, alkaline phosphatase, and lactate dehydrogenase, as well as some selected electrolytes were measured. Results: Results show that treatment with 200 mg and 250 mg/kg significantly (P < 0.05) rejuvenated these enzyme biomarkers while modulating the physiological levels of the serum electrolytes and kidney markers. Conclusion: C. longa exhibited a significant antioxidant potential that sustain the cells from the effect of S4D toxicity. Hence, the results indicate a possible ameliorative mechanism of the plant extract against S4D- induced hepato-renal injury. Therefore, the inclusion of C. longa into our daily diet might limit the effect of the hepato-renal injury.

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Restorative Effects of Aloe Vera Gel on Alcohol Induced Hepato-Nephrocellular Dysfunction

Cited by 3 publications

References 21 publications

Functional potential of Aloe vera juice against CCl4 induced hepatotoxicity in animal model

Functional potential of Aloe vera juice against CCl4 induced hepatotoxicity in animal model

Aqueous Extract of Aloe Vera Ameliorates Ethanol-Induced Liver Damage and Oxidative Stress in Balb/C Mice

Rejuvenating potentials of Curcuma longa on Sudan IV dye induced hepato-renal injury

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