Restoring electrical connection using a conductive biomaterial provides a new therapeutic strategy for rats with spinal cord injury

Shu, Bing; Sun, Xiaodan; Liu, Raynald; Jiang, Fenjun; Yu, Hao; Xu, Nan; An, Yu

doi:10.1016/j.neulet.2018.10.031

Cited by 41 publications

(34 citation statements)

References 21 publications

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“…The electrical conductivity range of the PPy‐coated scaffold fabricated in this study was compared to those reported in the literature for other PPy‐containing bioscaffolds with tissue engineering applications (Table 4). Electrically conductive polymeric systems can be prepared by coating PPy on a polymeric substrate 48,49 or incorporating PPy within the matrix 44,50 . Table 4 indicates that the PPy‐coated scaffolds in this work had an equal or a higher electrical conductivity than that of other polymeric systems prepared through PPy‐coating or blending with PPy.…”

Section: Resultsmentioning

confidence: 87%

Conductive poly(ε‐caprolactone)/polylactic acid scaffolds for tissue engineering applications: Synergy effect of zirconium nanoparticles and polypyrrole

Jafari

Mirzaei

Shafiei

et al. 2022

Polymers for Advanced Techs

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Biocompatible and electrically conductive porous scaffolds with a desirable hydrophilicity and degradation rate and suitable mechanical performance are highly favorable for tissue engineering and regenerative medicine applications. In this study, we fabricated three-dimensional (3D) porous bioscaffolds from poly(ε-caprolactone) and polylactic acid containing different concentrations of zirconia nanoparticles (n-ZrO 2 ) through freeze-drying technique. Afterward, the surface of the scaffolds was coated with an electrically conductive layer through in situ polymerization of polypyrrole (PPy) on the samples. Bioscaffolds exhibited a favorable range of mechanical properties and electrical conductivity, meeting the required mechanical performances and conductivity for a broad range of tissue engineering applications. Coating PPy on the scaffolds resulted in significantly higher hydrophilicity and faster biodegradation rate, as well as a noticeable enhancement on the in vitro cell attachment, proliferation, and viability. Our findings indicated that the simultaneous presence of n-ZrO 2 and PPy in the system presents a noticeable synergistic effect in overall properties and introduces the fabricated 3D porous scaffolds as promising candidates for tissue engineering and regenerative medicine applications.

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Section: Resultsmentioning

confidence: 87%

Conductive poly(ε‐caprolactone)/polylactic acid scaffolds for tissue engineering applications: Synergy effect of zirconium nanoparticles and polypyrrole

Jafari

Mirzaei

Shafiei

et al. 2022

Polymers for Advanced Techs

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show abstract

“…The scaffold was implanted into the spinal cord of rat T9 and completely resected. It is noteworthy that the PLA/PPy scaffolds significantly reduced astrocyte activation and increased the regeneration of axons after 6 weeks of injury ( Figures 4A–D ) ( Shu et al, 2019 ).…”

Section: Polymeric Fibers For Scimentioning

confidence: 97%

Polymeric Fibers as Scaffolds for Spinal Cord Injury: A Systematic Review

Cheng

Zhang

2022

Front. Bioeng. Biotechnol.

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Spinal cord injury (SCI) is a complex neurological condition caused by trauma, inflammation, and other diseases, which often leads to permanent changes in strength and sensory function below the injured site. Changes in the microenvironment and secondary injuries continue to pose challenges for nerve repair and recovery after SCI. Recently, there has been progress in the treatment of SCI with the use of scaffolds for neural tissue engineering. Polymeric fibers fabricated by electrospinning have been increasingly used in SCI therapy owing to their biocompatibility, complex porous structure, high porosity, and large specific surface area. Polymer fibers simulate natural extracellular matrix of the nerve fiber and guide axon growth. Moreover, multiple channels of polymer fiber simulate the bundle of nerves. Polymer fibers with porous structure can be used as carriers loaded with drugs, nerve growth factors and cells. As conductive fibers, polymer fibers have electrical stimulation of nerve function. This paper reviews the fabrication, characterization, and application in SCI therapy of polymeric fibers, as well as potential challenges and future perspectives regarding their application.

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“…[97] In vivo, the implantation of aligned conductive electrospun scaffolds in rats after spinal cord injury improved functional recovery and electrical signals measured as motorevoked potentials. [98] Thus, multicue scaffolds may hold great potential for application in neural tissue regeneration. The mechanisms underlying the beneficial effects of ES, however, require further exploration.…”

Section: Additional Solution Bathmentioning

confidence: 99%

3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration

Toftdal

Friec

et al. 2021

Small Science

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Tissue regeneration is a rapidly evolving and interdisciplinary field at the intersection of life science, biology, material science, and engineering. Centrally, it involves functional cell-free or cell-laden constructs or biomaterial scaffolds that are fabricated utilizing various strategies. [1] Cell-free biomaterial scaffolds implanted directly at the sites of injury may mechanically support local cells to promote local tissue repair. [2] Furthermore, they can be functionalized both on the surface or in the interior with bioactive materials to stimulate regeneration of functional tissues. [3] In cell therapy applications, cell-laden constructs may enhance both survival and differentiation of the therapeutic cells compared with cell transplantation alone. The grafted cells may then ideally replace lost tissue and/or exert beneficial effects on the host tissue. [4] Among different biomaterial constructs, 3D fibrous scaffolds recreate a 3D microenvironment, which closely resembles the native extracellular matrix (ECM), including both structural and biochemical properties that guide cell survival and differentiation. [5] Scaffolds with fibrous networks possess unique characteristics, including sufficiently high interconnected porosity, high specific surface area, tunable mechanical properties, as well as optimal morphological features. The high porosity of the fibrous scaffolds facilitates mass transfer for effective nutrient supply, oxygen diffusion, metabolic waste removal, and enhancement of intercellular communications, consequently allowing high cell viability and function throughout the entire scaffold. [6] In addition, compared with 2D culture, the 3D cell culture provides a more realistic biochemical and biomechanical microenvironment, [7] creating an optimal environment for cell migration, proliferation, and differentiation. Hence, nanofibrous scaffolds with appropriate biomechanical properties are highly suitable for tissue engineering. [8] Electrospinning, as a relatively simple and versatile fiber preparation technique, has been developed to create fiber-based constructs in combination with cells, bioactive molecules, proteins, and biocompatible nanomaterials. [9] Many studies have demonstrated that the electrospinning technology has the potential for significant progress within the field of tissue regeneration. Chen et al. [10] summarized the methods for producing electrospun 1D nanofiber bundles, 2D

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Restoring electrical connection using a conductive biomaterial provides a new therapeutic strategy for rats with spinal cord injury

Cited by 41 publications

References 21 publications

Conductive poly(ε‐caprolactone)/polylactic acid scaffolds for tissue engineering applications: Synergy effect of zirconium nanoparticles and polypyrrole

Conductive poly(ε‐caprolactone)/polylactic acid scaffolds for tissue engineering applications: Synergy effect of zirconium nanoparticles and polypyrrole

Polymeric Fibers as Scaffolds for Spinal Cord Injury: A Systematic Review

3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration

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