Restricting branched‐chain amino acids: an approach to improve metabolic health

Anderson, Jacob G.; Hintze, Kenzie; Marchant, Erik D.

doi:10.1113/jp276205

Cited by 7 publications

(5 citation statements)

References 5 publications

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“…Another animal study pointed out that the restriction of dietary BCAAs signi cantly decreased body weight and adiposity, and increased energy expenditure (27). However, very few studies have assessed the effects of dietary BCAA restriction on metabolism in humans (28). Two trials have found that weight loss induced by either gastric bypass surgery or sleeve gastrectomy among severely obese patients causes the same decline in circulating BCAAs (29,30).…”

Section: Discussionmentioning

confidence: 99%

Daily branch chained amino acid intakes and the risk of obesity among women with prior gestational diabetes mellitus

Yang

et al. 2021

Preprint

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Background Some studies have found that branched amino acid (BCAA) is associated with the risk of obesity among general population, however, not all the results were consistent. The present study aimed to investigate the association of daily BCAA intakes with the risk of postpartum overweight and abdominal obesity among women with prior gestational diabetes mellitus (GDM). Methods We performed a cross-sectional study of 1263 women with prior GDM at 1–5 years post-delivery. Logistic regression models were used to estimate the association of daily dietary intakes of BCAAs with the risk of overweight and abdominal obesity. Results The multivariable-adjusted odds ratio (OR) across quartiles of daily BCAA intakes were 1.42 (95% confidence interval [CI] 1.02–1.97), 1.00 (reference), 1.21 (95% CI 0.88–1.68), and 1.31 (95% CI 0.95–1.81) for general overweight, and 1.38 (95% CI 0.99–1.90), 1.00, 1.19 (95% CI 0.86–1.64), and 1.43 (95% CI 1.04–1.98) for abdominal obesity, respectively. Only women with the lowest quartile of daily BCAA intakes significantly increased the risks of general overweight (OR 1.49; 95 %CI 1.06–2.09) and abdominal obesity (OR 1.50; 95 %CI 1.08–2.11) compared with women at quartile 2 of daily BCAA intakes after further adjustment of daily energy intake. Conclusions The present study indicated U-shaped associations between daily BCAA intakes and the risk of general overweight and abdominal obesity among women with prior GDM.

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Section: Discussionmentioning

confidence: 99%

Daily branch chained amino acid intakes and the risk of obesity among women with prior gestational diabetes mellitus

Yang

et al. 2021

Preprint

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“…Cummings et al (28) pointed out that the restriction of dietary BCAA significantly decreased body weight and adiposity, increased energy expenditure, and improved glucose tolerance and insulin sensitivity in animal experiments. There are very few studies on the effects of dietary BCAA restriction on metabolism in humans (29). In the present study, our data indicated dietary BCAA intake was independently associated with childhood obesity and insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

Daily Branched‐Chain Amino Acid Intake and Risks of Obesity and Insulin Resistance in Children: A Cross‐Sectional Study

Lü

Liu

et al. 2020

Obesity

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This study aimed to investigate the association of daily branched-chain amino acid (BCAA) intake with the risks of obesity and insulin resistance in children of mothers with gestational diabetes mellitus (GDM). Methods: Daily BCAA intake was calculated by using a validated food frequency questionnaire in 996 children of mothers with GDM. The odds ratios (ORs) (95% CI) of childhood obesity and insulin resistance were obtained using logistic regression models. Results: The multivariable-adjusted ORs for overweight and insulin resistance increased across quartiles of daily BCAA intake (P < 0.05 for trend). Multivariable-adjusted ORs for each 1-SD increase in BCAA intake were 1.37 (1.16-1.62) for overweight and 1.19 (1.02-1.38) for insulin resistance. After additional adjustment of children's daily total energy intake, the OR was still significant for overweight risk but no longer significant for insulin resistance. There were positive associations of daily leucine, isoleucine, and valine intake with the risks for overweight and insulin resistance. Conclusions: Daily BCAA intake was associated with increased risks for overweight and insulin resistance in children of mothers with GDM, but this association was not fully independent of children's daily energy intake. Restriction in dietary BCAA may help prevent childhood obesity and insulin resistance.

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“…Furthermore, obesity, insulin resistance, and T2DM were associated with elevated levels of branched-chain amino acids (BCAAs) as risk factors for PD. Restricting BCAAs can improve metabolic health, induce weight loss, and increase insulin sensitivity and glycemic tolerance, as well as improve insulin resistance [ 238 , 239 , 240 , 241 ]. Reducing protein and amino acid content in the diet provides PD patients with an inexpensive and sustainable dietary intervention.…”

Section: Other Dietary Interventions On Pdmentioning

confidence: 99%

Dietary Restriction against Parkinson’s Disease: What We Know So Far

et al. 2022

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Dietary restriction (DR) is defined as a moderate reduction in food intake while avoiding malnutrition. The beneficial effects of DR are being increasingly acknowledged in aging and in a series of age-related neurodegenerative disorders, for example, Parkinson’s disease (PD). To date, the pathogenesis of PD remains elusive and there is no cure for it in spite of intensive research over decades. In this review, we summarize the current knowledge on the efficacy of DR on PD, focusing on the underlying mechanisms involving general metabolism, neuroendocrinolgy, neuroinflammation, gut microbiome, and so on. We anticipate that this review will provide future perspectives for PD prevention and treatment.

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Restricting branched‐chain amino acids: an approach to improve metabolic health

Cited by 7 publications

References 5 publications

Daily branch chained amino acid intakes and the risk of obesity among women with prior gestational diabetes mellitus

Daily branch chained amino acid intakes and the risk of obesity among women with prior gestational diabetes mellitus

Daily Branched‐Chain Amino Acid Intake and Risks of Obesity and Insulin Resistance in Children: A Cross‐Sectional Study

Dietary Restriction against Parkinson’s Disease: What We Know So Far

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