Restrictive ventilatory impairment is associated with poor outcome in patients with cT1aN0M0 peripheral squamous cell carcinoma of the lung

Tao, Hiroyuki; Soh, Junichi; Yamamoto, Hiromasa; Fujiwara, Toshiya; Ueno, Toshihide; Hayama, Makio; Okazaki, Mikio; Sugimoto, Ryujiro; Yamashita, Motohiro; Sano, Yoshifumi; Okabe, Kazunori; Matsuura, Motoki; Kataoka, Kazuhiko; Moriyama, Shigeharu; Toyooka, Shinichi; Miyoshi, Shinichiro

doi:10.21037/jtd.2017.10.70

Cited by 6 publications

(3 citation statements)

References 38 publications

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“…6) Restrictive ventilatory impairment is associated with a poor prognosis in patients who undergo surgery for primary lung cancer. [13][14][15] Our data also indicate that restrictive ventilatory impairment is an independent prognostic factor for both overall survival and disease-free survival in patients who undergo pulmonary resection for a second primary lung cancer. Moreover, in this study, death from another disease was significantly more common in these patients when restrictive ventilatory impairment was present.…”

Section: Discussionsupporting

confidence: 61%

Restrictive Ventilatory Impairment as a Poor Prognostic Factor in Patients Who Undergo Surgical Resection for Metachronous Second Primary Lung Cancer

Komatsu¹,

Izumi²,

Tsukioka³

et al. 2023

ATCS

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To evaluate the prognostic impact of restrictive ventilatory impairment in patients who undergo pulmonary resection of metachronous second primary lung cancer. Methods: The clinical characteristics and surgical outcomes of 70 patients with meta chronous second primary lung cancer were analyzed. Results: The surgical procedures consisted of wedge resection in 40 patients, segmentectomy in 17, lobectomy in 12, and completion pneumonectomy in one. Patients who underwent ipsilateral pulmonary resection developed more perioperative complications (p = 0.0339).Threeyear and 5year overall survival rates were 78.2% and 69.2%, respectively. In uni variate analysis, sex, restrictive ventilatory impairment, and histology of second primary lung cancer were significantly poor prognostic factors (all p <0.05). Multivariate analysis identified restrictive ventilatory impairment to be an independent predictor of a poor prognosis (p = 0.0193). In the 22 patients who died, the cause of death was lung cancer in 11 and other diseases, including pneumonia and respiratory failure, in 11. Death from another disease was significantly more common in patients with restrictive ventilatory impairment (p = 0.0216). Conclusion: Restrictive ventilatory impairment was an independent predictor of a poor prognosis in patients with a second primary lung cancer. Restrictive ventilatory impair ment as a result of repeated thoracic surgery may increase the likelihood of death from another disease.

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Section: Discussionsupporting

confidence: 61%

Restrictive Ventilatory Impairment as a Poor Prognostic Factor in Patients Who Undergo Surgical Resection for Metachronous Second Primary Lung Cancer

Komatsu¹,

Izumi²,

Tsukioka³

et al. 2023

ATCS

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“…Long-term OS was positively correlated with better PFTs, but interestingly, decreased values of FEV1 and DLCO were differentially associated with survival, thus revealing the unreliability of percent predicted values in the prediction of long-term outcomes. In contrast, in a Japanese study of 222 patients with cT1aN0M0 peripheral lung squamous cell carcinoma, a decreased vital capacity (<80%), but not a decreased FEV1, was associated with decreased OS following resection (15). In a similar study conducted in China, the presence of moderate to severe chronic obstructive pulmonary disease, as determined by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria predicted for worse outcomes for lung cancer after adjusting for confounding factors (16).…”

Section: Discussionmentioning

confidence: 74%

Preoperative Pulmonary Function Tests (PFTs) and Outcomes from Resected Early Stage Non-small Cell Lung Cancer (NSCLC)

Almquist

Khanal

Smith

et al. 2018

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“…In cervical cancer, although squamous cell carcinoma antigen (SCCA) 9 has been applied in clinical practice, its specificity and sensitivity are far from satisfactory 10 . For example, SCCA also increases in other types of squamous cell carcinoma 11–13 and even in nontumour diseases 14 . In addition, it is not good for identifying and monitoring cervical adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

Identification of a novel six‐gene signature with potential prognostic and therapeutic value in cervical cancer

Shi

Guo

et al. 2021

Cancer Medicine

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Introduction Cervical cancer has high mortality, high recurrence and poor prognosis. Although prognostic biomarkers such as clinicopathological features have been proposed, their accuracy and precision are far from satisfactory. Therefore, novel biomarkers are urgently needed for disease surveillance, prognosis prediction and treatment selection. Materials Differentially expressed genes (DEGs) between cervical cancer and normal tissues from three microarray datasets extracted from the Gene Expression Omnibus platform were identified and screened. Based on these DEGs, a six‐gene prognostic signature was constructed using cervical squamous cell carcinoma and endocervical adenocarcinoma data from The Cancer Genome Atlas. Next, the molecular functions and related pathways of the six genes were investigated through gene set enrichment analysis and co‐expression analysis. Additionally, immunophenoscore analysis and the QuartataWeb Server were employed to explore the therapeutic value of the six‐gene signature. Results We discovered 178 overlapping DEGs in three microarray datasets and established a six‐gene (APOC1, GLTP, ISG20, SPP1, SLC24A3 and UPP1) prognostic signature with stable and excellent performance in predicting overall survival in different subgroups. Intriguingly, the six‐gene signature was closely associated with the immune response and tumour immune microenvironment. The six‐gene signature might be used for predicting response to immune checkpoint inhibitors (ICIs) and the six genes may serve as new drug targets for cervical cancer. Conclusion Our study established a novel six‐gene (APOC1, GLTP, ISG20, SPP1, SLC24A3 and UPP1) signature that was closely associated with the immune response and tumour immune microenvironment. The six‐gene signature was indicative of aggressive features of cervical cancer and therefore might serve as a promising biomarker for predicting not only overall survival but also ICI treatment effectiveness. Moreover, three genes (UPP1, ISG20 and GLTP) within the six‐gene signature have the potential to become novel drug targets.

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Restrictive ventilatory impairment is associated with poor outcome in patients with cT1aN0M0 peripheral squamous cell carcinoma of the lung

Abstract: A restrictive ventilatory impairment negatively affects the outcome of patients with cT1aN0M0 peripheral SqCC lung cancer.

Cited by 6 publications

References 38 publications

Restrictive Ventilatory Impairment as a Poor Prognostic Factor in Patients Who Undergo Surgical Resection for Metachronous Second Primary Lung Cancer

Restrictive Ventilatory Impairment as a Poor Prognostic Factor in Patients Who Undergo Surgical Resection for Metachronous Second Primary Lung Cancer

Preoperative Pulmonary Function Tests (PFTs) and Outcomes from Resected Early Stage Non-small Cell Lung Cancer (NSCLC)

Identification of a novel six‐gene signature with potential prognostic and therapeutic value in cervical cancer

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